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Autor:
Dong-bao Chen, Jin Bai
Publikováno v:
Hypertension
Pregnancy and VEGF (vascular endothelial growth factor) stimulate uterine artery endothelial cell (UAEC) hydrogen sulfide production via selectively upregulating CBS (cystathionine β-synthase) but not CSE (cystathionine γ-lyase) expression. This st
Autor:
Yi‐Dong Yang, Chang Liu, Jian Huang, Chen Dewei, Shouxian Wang, Gang Xu, Yuqi Gao, Jiale Hao, Gang Wu, Yu Wang, Mengjie Zhang, Wenxiang Gao, Bing Ni
Publikováno v:
Hypertension. 78:1080-1091
EPAS1 (endothelial PAS domain protein 1), as the major effect gene for the adaptation to chronic hypoxia, is required for hypoxic pulmonary hypertension (HPH). Downregulated EPAS1 ameliorates the development of HPH. We confirmed that EPAS1-specific i
Autor:
Jeong-Min Kim, Eun-Kyung Jo, Yeongju Yeo, Eunhee S. Yi, Wonhee Suh, Koung Li Kim, Sang Gyu Park, S. J. Seo, Jong-Hyuk Sung, Ryul-I Kim
Publikováno v:
Hypertension. 76:1778-1786
Loss of BMP (bone morphogenic protein) signaling induces a phenotype switch of pulmonary arterial smooth muscle cells (PASMCs), which is the pathological basis of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). Here, we identi
Autor:
Masafumi Watanabe, Tetsu Watanabe, Hiroki Takahashi, Yuta Kobayashi, Harutoshi Tamura, T Aono, Ken Watanabe, Yoichiro Otaki, Tetsuro Shishido, Jun Goto, Masahiro Wanezaki, Takanori Arimoto, Satoshi Nishiyama, Shigehiko Kato, Daisuke Kutsuzawa
Publikováno v:
Hypertension. 76:1868-1878
The HECT (homologous to the E6-AP carboxyl terminus)-type ubiquitin E3 ligase ITCH is an enzyme that plays an important role in ubiquitin-proteasomal protein degradation. Disheveled proteins (Dvl1 [disheveled protein 1], Dvl2, and Dvl3) are the main
Autor:
R. James White, Sharon Senchanthisai, Jinjiang Pang, Chao Xue, Bradford C. Berk, Mark P. Sowden
Publikováno v:
Hypertension. 76:1113-1123
Oxidative stress and inflammation play key roles in development of pulmonary arterial hypertension (PAH). We previously reported that an endothelial cell (EC)-specific cyclophilin A overexpression mouse developed many characteristics of PAH. In other
Autor:
Robert M. Carey, Nancy L. Howell, Brant E. Isakson, Luca Musante, Sabrina La Salvia, Thu H Le, Miranda E. Good, Uta Erdbrügger
Publikováno v:
Hypertension. 75:218-228
Extracellular vesicles (EVs) have been described as novel biomarkers and bioactivators in vascular dysfunction in hypertension. However, the mechanism(s) by which EVs affect vascular function is unknown. To examine the effects of EVs on endothelial-d
Publikováno v:
Hypertension. 74:467-476
Autor:
Fiona C Brownfoot, Roxanne Hastie, Kirsten R Palmer, Sally Beard, Ping Cannon, Stephen Tong, Natalie J. Hannan, Vi Nguyen, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino
Publikováno v:
Hypertension. 73:659-670
Preeclampsia is a hypertensive disorder of pregnancy characterized by maternal endothelial dysfunction and end-organ damage. The antiangiogenic factor, sFlt-1 (soluble FMS-like tyrosine kinase-1) has been strongly implicated in the pathogenesis of pr
Autor:
Martin Reincke, Suzette Moes, Marc Y. Donath, Katharina Glatz, Eva Dazert, Paul Jenö, Michael N. Hall, Matthias J. Betz, Cécile Pfaff, Marco Colombi, Felix Beuschlein, Marta M. Swierczynska
Publikováno v:
Hypertension. 73:469-480
Primary aldosteronism is a disease of excessive production of adrenal steroid hormones and the most common cause of endocrine hypertension. Primary aldosteronism results mainly from bilateral adrenal hyperplasia or unilateral aldosterone-producing ad
Publikováno v:
Hypertension. 71:804-810
Angiotensin II is the most important endocrine ligand in the renin–angiotensin system (RAS), contributing to the development of several cardiovascular diseases including hypertension.1 Angiotensin II mediates its signal transduction and functions v