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Autor:
Yi‐Dong Yang, Chang Liu, Jian Huang, Chen Dewei, Shouxian Wang, Gang Xu, Yuqi Gao, Jiale Hao, Gang Wu, Yu Wang, Mengjie Zhang, Wenxiang Gao, Bing Ni
Publikováno v:
Hypertension. 78:1080-1091
EPAS1 (endothelial PAS domain protein 1), as the major effect gene for the adaptation to chronic hypoxia, is required for hypoxic pulmonary hypertension (HPH). Downregulated EPAS1 ameliorates the development of HPH. We confirmed that EPAS1-specific i
Autor:
Jeong-Min Kim, Eun-Kyung Jo, Yeongju Yeo, Eunhee S. Yi, Wonhee Suh, Koung Li Kim, Sang Gyu Park, S. J. Seo, Jong-Hyuk Sung, Ryul-I Kim
Publikováno v:
Hypertension. 76:1778-1786
Loss of BMP (bone morphogenic protein) signaling induces a phenotype switch of pulmonary arterial smooth muscle cells (PASMCs), which is the pathological basis of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). Here, we identi
Autor:
Robert M. Carey, Nancy L. Howell, Brant E. Isakson, Luca Musante, Sabrina La Salvia, Thu H Le, Miranda E. Good, Uta Erdbrügger
Publikováno v:
Hypertension. 75:218-228
Extracellular vesicles (EVs) have been described as novel biomarkers and bioactivators in vascular dysfunction in hypertension. However, the mechanism(s) by which EVs affect vascular function is unknown. To examine the effects of EVs on endothelial-d
Publikováno v:
Hypertension. 74:467-476
Publikováno v:
Hypertension. 71:804-810
Angiotensin II is the most important endocrine ligand in the renin–angiotensin system (RAS), contributing to the development of several cardiovascular diseases including hypertension.1 Angiotensin II mediates its signal transduction and functions v
Autor:
Jin-kun Wen, Xuan Zhang, Xin-hua Zhang, Bin Zheng, Zhan Yang, Ming Zhang, Wei Zhang, Ruo-nan Zhang, Ling-yan Yue, Ming He
Publikováno v:
Hypertension. 66:412-421
The TMEM16A protein is an important component of Ca 2+ -dependent Cl − channels (CaCCs) in vascular smooth muscle cells. A recent study showed that TMEM16A inhibits angiotensin II–induced proliferation in rat basilar smooth muscle cells. However,
Autor:
Chao Ling Yang, Emmanuelle Vidal-Petiot, Nicholas P. Meermeier, Norma Vázquez, David H. Ellison, Chong Zhang, María Chávez-Canales, Lorena Rojas-Vega, Christelle Soukaseum, Diana Pacheco-Alvarez, Gerardo Gamba, Juliette Hadchouel, Shaunessy Rogers, Xavier Jeunemaitre, María Castañeda-Bueno, Erika Moreno
Publikováno v:
Hypertension. 64:1047-1053
The with-no-lysine (K) kinases, WNK1 and WNK4, are key regulators of blood pressure. Their mutations lead to familial hyperkalemic hypertension (FHHt), associated with an activation of the Na-Cl cotransporter (NCC). Although it is clear that WNK4 mut
Publikováno v:
Hypertension. 55:1398-1405
Recent reports indicate that (−)-epicatechin can exert cardioprotective actions, which may involve endothelial nitric oxide synthase (eNOS)-mediated nitric oxide production in endothelial cells. However, the mechanism by which (−)-epicatechin act
Publikováno v:
Hypertension. 53:189-195
Tetrahydrobiopterin is an essential cofactor required for the synthesis of nitric oxide. GTP cyclohydrolase I (GTPCH I) is the rate limiting enzyme for tetrahydrobiopterin production in endothelial cells, yet little is known about the subcellular loc
Autor:
Ralf Dechend, Lydia Hering, Robert Pijnenborg, Joon-Keun Park, Fatimunnisa Qadri, Anne Cathrine Staff, Maren Wellner, Dominik N. Müller, Berthold Huppertz, Stefan Verlohren, Friedrich C. Luft, Florian Herse
Publikováno v:
Hypertension. 51:554-559
Maternal spiral artery remodeling is the consequence of controlled trophoblast invasive interaction with the maternal cellular environment and is fundamentally important for successful placentation. In preeclampsia, trophoblast invasion is shallow, r