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Autor:
Qiu Jiang, Dong Liu, Wiebke Herzog, Ferdinand le Noble, Christian S. M. Helker, Mariana Lagos-Quintana, Yu Shi
Publikováno v:
Hypertension. 62:592-598
Microvascular rarefaction increases vascular resistance and pressure in systemic arteries and is a hallmark of fixed essential hypertension. Preventing rarefaction by activation of angiogenic processes could lower blood pressure. Endothelial tip cell
Publikováno v:
Hypertension. 54:427-433
In intact vessels, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) act as an integrated system, possibly through reactive oxygen species (ROS). Using a coculture system we tested whether ECs modulate VSMC redox status by regulating a
Autor:
Ralf Dechend, Lydia Hering, Robert Pijnenborg, Joon-Keun Park, Fatimunnisa Qadri, Anne Cathrine Staff, Maren Wellner, Dominik N. Müller, Berthold Huppertz, Stefan Verlohren, Friedrich C. Luft, Florian Herse
Publikováno v:
Hypertension. 51:554-559
Maternal spiral artery remodeling is the consequence of controlled trophoblast invasive interaction with the maternal cellular environment and is fundamentally important for successful placentation. In preeclampsia, trophoblast invasion is shallow, r
Publikováno v:
Hypertension. 48:804-811
The proteins that form the gap junctions (connexins) are widely expressed in organs that are central to the development of hypertension: endocrine organs, kidney, brain, heart, and vasculature (Figure 1). Surprisingly, there is little information on
Autor:
L J Ignarro
Publikováno v:
Hypertension. 16:477-483
Nitric oxide first captured the interest of biologists when this inorganic molecule was found to activate cytosolic guanylate cyclase and stimulate cyclic guanosine monophosphate (GMP) formation in mammalian cells. Further studies led to the finding
Publikováno v:
Europe PubMed Central
By virtue of its location at the interface of flowing blood and vascular tissue, the endothelial cell monolayer is in a unique position for interactions with soluble and cellular elements of the blood on one side and with component cells of the vascu