Zobrazeno 1 - 10
of 171
pro vyhledávání: ''
Mantle cell lymphoma with chronic lymphocytic leukemia-like features: a diagnostic mimic and pitfall
Autor:
Pei Lin, Mahsa Khanlari, Francisco Vega, Lianqun Qiu, Sa A. Wang, Chi Young Ok, Shaoying Li, C. Cameron Yin, Jie Xu, Sophia Garces, L. Jeffrey Medeiros, Guilin Tang
Publikováno v:
Human Pathology. 119:59-68
Mantle cell lymphoma (MCL) is a mature B-cell neoplasm characterized by t(11;14)(q13;q32) and cyclin D1 overexpression in >95% of cases. Classic MCL cases are composed of a monotonous population of small to medium-sized lymphocytes with irregular nuc
Autor:
Alexandra Legge, Kirsten E. Fleming, Daniel Gaston, Thai Yen Ly, Sylvia Pasternak, Michael D. Carter, Noreen M. Walsh, Ryan C. DeCoste
Publikováno v:
Human Pathology. 117:31-41
Summary Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma. Oncogenesis occurs via Merkel cell polyomavirus–mediated (MCPyV+) and/or ultraviolet radiation–associated (MCPyV−) pathways. Advanced clinical stage a
Autor:
Mingming Yuan, Bei Wang, Rongrong Chen, Xuefeng Xia, Huang Chen, Dingrong Zhong, Jia Guo, Changxi Wang
Publikováno v:
Human Pathology. 114:90-98
Anaplastic lymphocyte kinase (ALK) rearrangement, a key oncogenic driver promoting the expression of ALK protein in tumor cells, is found in 2%-7% of patients with nonsmall cell lung cancer (NSCLC). ALK fusion is routinely determined with immunohisto
Autor:
Vassiliki Kotoula, Helen Sgouramali, Stavroula Pervana, Kyriakos Chatzopoulos, Georgia-Angeliki Koliou, George Pentheroudakis, Georgia Kafiri, Dimitrios Pectasides, Pavlos Papakostas, Vasilios Karavasilis, Elissavet Pazarli, George Fountzilas, Sofia Chrisafi, Prodromos Hytiroglou, Georgios Tsoulfas, Eleni Giannoulatou, Kyriaki Papadopoulou
Publikováno v:
Human Pathology. 107:104-116
Although primary colorectal carcinomas (CRCs) frequently share genetic alterations with their metastases, morphologic surrogates reflecting the genotype contexture of metastases remain largely unknown. We investigated phenotype/genotype associations
Autor:
Kenji Suzuki, Yoshiyuki Suehara, Tsuyoshi Saito, Kazuya Takamochi, Kazuhisa Takahashi, Fumiyuki Takahashi, Kei Sano, Kieko Hara, Takuo Hayashi, Satsuki Kishikawa, Takashi Yao, Shinji Kohsaka
Publikováno v:
Human Pathology. 103:42-51
Summary The extensive clinical applications of next-generation sequence analyzers have made uncommon and compound EGFR mutations more prevalent than previously described. However, clinicopathological impacts of compound EGFR mutations in lung adenoca
Autor:
Anna Sebestyén, Yanyan Lou, Judit Pápay, Tracy L. Majewicz, Ildikó Krencz, Andras Khoor, Gabrielle F. Lutz
Publikováno v:
Human Pathology. 93:74-80
Small cell lung carcinoma (SCLC) accounts for approximately 15% of all lung cancers and remains a challenging disease, with no significant improvement in the field of targeted therapies. The RICTOR gene (rapamycin-insensitive companion of mTOR [mamma
Autor:
Roman Carlos, Thayná Melo de Lima Morais, Oslei Paes de Almeida, Manoela Domingues Martins, Ciro Dantas Soares, Albina Altemani, Fernanda Viviane Mariano
Publikováno v:
Human Pathology. 92:59-66
Mammaglobin is expressed in breast and salivary gland secretory carcinomas; however, its expression in salivary duct carcinomas (SDCs) still not well established. Therefore, the aim of this study was to investigate the presence and distribution of ma
Autor:
Hailing Li, Ke Liang, Xiaotong Jing, Shuang Ge, Zhiqiang Zhou, Yan Wang, Jun Wang, Cuijuan Zhang, Shuyu Mei
Publikováno v:
Human Pathology. 84:309-320
Classical Hodgkin lymphoma (cHL) and ALK- anaplastic large cell lymphoma (ALCL) share many morphologic and immunohistochemical features, causing difficulties in differential diagnosis. Aberrant T-cell/B-cell antigen (TCA/BCA) expression in cHL/ALCL h
Publikováno v:
Human Pathology. 81:166-175
Aberrant Wnt signaling is a hallmark of solid pseudopapillary neoplasms (SPNs) of the pancreas. Transcription factor E3 (TFE3) plays a critical role in activation and regulation of the Wnt pathway and is predicted to be a candidate gene implicated in
Autor:
Seong Jin Cho, Eun Sook Nam, Mi Jung Kwon, Jinwon Seo, Mineui Hong, Ji-Young Choe, Hye-Rim Park, Soo Kee Min, Eun Soo Kim, Bumjung Park, Kyueng-Whan Min, Young Soo Rho
Publikováno v:
Human Pathology. 80:28-39
Programmed cell death-1 ligand-1 (PD-L1), essential for immune evasion, is a potential candidate for pathogenesis and therapeutic target of human papillomavirus (HPV)-positive tonsillar squamous cell carcinomas (TSCCs). MET/hepatocyte growth factor s