Zobrazeno 11 - 20
of 171
pro vyhledávání: ''
Autor:
Juliana Pereira, Jenna Weber, Shuchun Zhao, Benjamin A. Pinsky, Luis Alberto de Padua Covas Lage, Maria Claudia Nogueira Zerbini, Cristiane R. Ferreira, Malaya K. Sahoo, Yasodha Natkunam
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Summary Forkhead box P3 (FOXP3) is a specific marker for regulatory T-cells (Tregs). We report 6 cases of T-cell lymphomas with Treg phenotype based on diffuse positivity for FOXP3 in tumor cells. The patients showed a median age of 56 years with a m
Autor:
Jessica Van Ziffle, Linlin Wang, Nancy Y. Greenland, Yen-Chun Liu, Sonam Prakash, Zhongxia Qi
Publikováno v:
Human pathology. 108
Summary Myeloid sarcoma (MS) is a rare manifestation of acute myeloid leukemia (AML) characterized by extramedullary proliferation of myeloid blasts. Owing to the rarity of MS, the clonal evolution of cell populations giving rise to MS is not well un
Autor:
Naoki Yanagawa, Makoto Endo, Noriyuki Yamada, Noriyuki Uesugi, Shin-ya Ogata, Satoshi Shiono, Tamotsu Sugai, Ryo Sugimoto, Mitsumasa Osakabe
Publikováno v:
Human pathology. 108
Programmed death ligand 1 (PD-L1) protein expression is a proposed predictive biomarker of immunotherapy; thus, identification of the clinicopathological and molecular characteristics associated with PD-L1 expression is important and necessary. We ex
Autor:
Yoshinao Oda, Daisuke Kiyozawa, Fumio Kinoshita, Masatoshi Eto, Kenichi Kohashi, Dai Takamatsu, Shin Ishihara, Yu Toda
Publikováno v:
Human pathology. 101
Summary Renal cell carcinoma (RCC) with sarcomatoid changes and rhabdoid features has shown poor outcomes. Several immune checkpoint inhibitors including programmed cell death protein 1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors have been ap
Publikováno v:
Human Pathology. 77:159-165
Summary The aim of the present study is to elucidate the clinicopathological significance and prognostic role of micropapillary pattern (MPP) in colorectal cancer (CRC). We investigated the correlation between the presence of MPP and clinicopathologi
Autor:
Elena Ratner, Stefan Gysler, Pei Hui, Joanne B. Weidhaas, Sunitha Nallur, Taiwo A. Togun, Thomas J. Rutherford, Mohamed Uduman, Christine E. Brambs, Daniel Estévez Prado, Alessandro D. Santin, Peter E. Schwartz
Publikováno v:
Human Pathology. 76:133-140
Synchronous endometrial and ovarian malignancies occur in 5% of women presenting with endometrial cancer and 10% of patients presenting with ovarian malignancy. When a high-grade serous carcinoma concurrently involves both ovary and endometrium, path
Autor:
Yanming Zhang, Alain Mina, Lawrence J. Jennings, Jessica K. Altman, Juehua Gao, Kwang Youn Kim, Madina Sukhanova, Xinyan Lu, Yi Hua Chen
Publikováno v:
Human pathology. 98
Chromothripsis is a unique type of genomic instability and is recognized in various cancers. In myeloid neoplasms (MNs), chromothripsis was linked to poor prognosis and specific genetic alterations (complex karyotype, 5q deletions, and loss of TP53).
Publikováno v:
Human Pathology. 75:81-90
Programmed cell death protein 1 (PD-1) and indoleamine 2,3-dioxygenase (IDO) are both immunosuppressive proteins. Here, we investigated the relationship between PD-1 and IDO in the tumor microenvironment (TME) and in tumor-draining lymph nodes (TDLNs
Publikováno v:
Human Pathology. 75:71-80
Claudin-4 (CLDN4) is a member of the claudin transmembrane protein family, which consists of integral membrane proteins that are components of the epithelial cell tight junctions; these tight junctions regulate movement of solutes and ions through th
Autor:
Ann M. Moyer, J. Kenneth Schoolmeester, Jodi M. Carter, Jamie N. Bakkum-Gamez, McKinsey L. Goodenberger, Gary L. Keeney
Publikováno v:
Human Pathology. 70:14-26
Germline BRCA mutations account for a significant proportion of genetic/familial risk of breast and ovarian cancer (GBOC) susceptibility, but a broader spectrum of GBOC susceptibility genes has emerged in recent years. Genotype-to-phenotype correlati