Zobrazeno 1 - 10
of 93
pro vyhledávání: ''
Autor:
Ann E. Walts, Alberto M. Marchevsky
Publikováno v:
Human Pathology. 60:16-23
The checkpoint protein programmed cell death ligand-1 protein (PD-L1) binds to its receptor (PD-1) activating the PD-L1/PD-1 pathway, an important therapeutic target. There is limited information regarding PD-L1 and PD-1 expression in thymic lesions.
Publikováno v:
Human Pathology. 58:47-53
MicroRNA (miR)-497 plays a tumor-suppressive role in several malignancies and is involved in glioma invasiveness and resistance to chemotherapy. To add to the knowledge of the clinical significance of miR-497 in human gliomas, quantitative real-time
Autor:
George J. Netto, Isabela Werneck da Cunha, Maria Angelica Mendoza Rodriguez, Diana Taheri, Nickolas Papadopoulos, Kazutoshi Fujita, Christopher J. VandenBussche, Dilek Ertoy, Bert Vogelstein, Kenneth W. Kinzler, Yuxuan Wang, Doreen Nguyen, Morgan L. Cowan, Gunes Guner, Maria Del Carmen Rodriguez Pena, Isaac Kinde, Simeon Springer, Mathew T. Olson, Trinity J. Bivalacqua
Publikováno v:
Human Pathology. 53:8-13
TERT promoter mutations (TERT-mut) have been detected in 60% to 80% of urothelial carcinomas. A molecular urine-based screening assay for the detection of TERT-mut is currently being pursued by our group and others. A small but significant number of
Autor:
Minako Hirahashi, Yoshiteru Kumagae, Eiji Oki, Hidetaka Yamamoto, Yukiko Kohno, Yoshinao Oda, Masafumi Nakamura
Publikováno v:
Human Pathology. 52:145-152
The effects of oxidative stress in adenocarcinomas of gastric cardia (AGCs) have not been fully elucidated. With a strict definition of AGC, we examined the immunohistochemical expressions of inducible nitric oxide synthase; 8-hydroxy-deoxyguanosine;
Autor:
Steve Doucette, Noreen M. Walsh, Jonathan H. Lai, Kirsten E. Fleming, Sylvia Pasternak, Thai Yen Ly, Marek Godlewski
Publikováno v:
Human Pathology. 46:1290-1296
Merkel cell polyomavirus is of oncogenic significance in approximately 80% of Merkel cell carcinomas. Morphological subcategories of the tumor differ in regard to viral status, the rare combined type being uniformly virus negative and the predominant
A subset of prostatic basal cell carcinomas harbor the MYB rearrangement of adenoid cystic carcinoma
Publikováno v:
Human Pathology. 46:1204-1208
Adenoid cystic carcinoma (ACC) is a basaloid tumor consisting of myoepithelial and ductal cells typically arranged in a cribriform pattern. Adenoid cystic carcinoma is generally regarded as a form of salivary gland carcinoma, but it can arise from si
Publikováno v:
Human Pathology. 46:1006-1014
This study aimed to evaluate the expression of H2B monoubiquitination enzyme (uH2B) and ubiquitin-specific protease enzyme 22 (USP22) in colon carcinoma and establish a correlation between the expression of these enzymes and clinicopathological param
Autor:
Bruce F. Kimler, Marilyn K. Davis, Fang Fan, Ossama Tawfik, Deepthi S. Rao, Warren B. Nothnick
Publikováno v:
Human Pathology. 46:876-883
Triple negative (TN) (estrogen receptor [ER], progesterone receptor [PR] and HER2-) are highly aggressive, rapidly growing, hormone-unresponsive tumors diagnosed at later stage that affect younger women with shorter overall survival. Most TN tumors a
Autor:
Mrinal M. Gounder, Narasimhan P. Agaram, Richard D. Carvajal, Sandra P. D'Angelo, Li-Xuan Qin, Mary Louise Keohan, Mark A. Dickson, Gary K. Schwartz, William D. Tap, Alexander N. Shoushtari, Deborah Kuk
Publikováno v:
Human Pathology. 46:357-365
The prognostic and predictive implications of programmed death-ligand 1 (PD-L1) is unknown in sarcoma. We sought to examine the immune milieu in sarcoma specimens. We evaluated PD-L1 expression by immunohistochemistry in sarcoma specimens and quantif
Autor:
Guoli Chen, Li Hui Tseng, Jonathan C. Dudley, Kirstin Smith, Christopher D. Gocke, Ming Tseh Lin, James R. Eshleman, Grzegorz T. Gurda
Publikováno v:
Human Pathology. 46:113-119
Detection of B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutations is required to predict response to BRAF or mitogen-activated protein kinase kinase 1 and 2 inhibitors in metastatic melanoma. Lymph node (LN) specimens carrying melanoma cell