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Mantle cell lymphoma with chronic lymphocytic leukemia-like features: a diagnostic mimic and pitfall
Autor:
Pei Lin, Mahsa Khanlari, Francisco Vega, Lianqun Qiu, Sa A. Wang, Chi Young Ok, Shaoying Li, C. Cameron Yin, Jie Xu, Sophia Garces, L. Jeffrey Medeiros, Guilin Tang
Publikováno v:
Human Pathology. 119:59-68
Mantle cell lymphoma (MCL) is a mature B-cell neoplasm characterized by t(11;14)(q13;q32) and cyclin D1 overexpression in >95% of cases. Classic MCL cases are composed of a monotonous population of small to medium-sized lymphocytes with irregular nuc
Autor:
Alexandra Legge, Kirsten E. Fleming, Daniel Gaston, Thai Yen Ly, Sylvia Pasternak, Michael D. Carter, Noreen M. Walsh, Ryan C. DeCoste
Publikováno v:
Human Pathology. 117:31-41
Summary Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma. Oncogenesis occurs via Merkel cell polyomavirus–mediated (MCPyV+) and/or ultraviolet radiation–associated (MCPyV−) pathways. Advanced clinical stage a
Autor:
Vassiliki Kotoula, Helen Sgouramali, Stavroula Pervana, Kyriakos Chatzopoulos, Georgia-Angeliki Koliou, George Pentheroudakis, Georgia Kafiri, Dimitrios Pectasides, Pavlos Papakostas, Vasilios Karavasilis, Elissavet Pazarli, George Fountzilas, Sofia Chrisafi, Prodromos Hytiroglou, Georgios Tsoulfas, Eleni Giannoulatou, Kyriaki Papadopoulou
Publikováno v:
Human Pathology. 107:104-116
Although primary colorectal carcinomas (CRCs) frequently share genetic alterations with their metastases, morphologic surrogates reflecting the genotype contexture of metastases remain largely unknown. We investigated phenotype/genotype associations
Autor:
Kenji Suzuki, Yoshiyuki Suehara, Tsuyoshi Saito, Kazuya Takamochi, Kazuhisa Takahashi, Fumiyuki Takahashi, Kei Sano, Kieko Hara, Takuo Hayashi, Satsuki Kishikawa, Takashi Yao, Shinji Kohsaka
Publikováno v:
Human Pathology. 103:42-51
Summary The extensive clinical applications of next-generation sequence analyzers have made uncommon and compound EGFR mutations more prevalent than previously described. However, clinicopathological impacts of compound EGFR mutations in lung adenoca
Autor:
Hailing Li, Ke Liang, Xiaotong Jing, Shuang Ge, Zhiqiang Zhou, Yan Wang, Jun Wang, Cuijuan Zhang, Shuyu Mei
Publikováno v:
Human Pathology. 84:309-320
Classical Hodgkin lymphoma (cHL) and ALK- anaplastic large cell lymphoma (ALCL) share many morphologic and immunohistochemical features, causing difficulties in differential diagnosis. Aberrant T-cell/B-cell antigen (TCA/BCA) expression in cHL/ALCL h
Autor:
Naoki Yanagawa, Makoto Endo, Noriyuki Yamada, Noriyuki Uesugi, Shin-ya Ogata, Satoshi Shiono, Tamotsu Sugai, Ryo Sugimoto, Mitsumasa Osakabe
Publikováno v:
Human pathology. 108
Programmed death ligand 1 (PD-L1) protein expression is a proposed predictive biomarker of immunotherapy; thus, identification of the clinicopathological and molecular characteristics associated with PD-L1 expression is important and necessary. We ex
Publikováno v:
Human pathology. 94
Summary Recent whole-genome sequencing showed frequent mutations of ARID1A in gastric cancer (GC). In this study of a large independent Central European cohort, we evaluated the expression of ARID1A in whole tissue sections (WTS) of GC testing the fo
Autor:
Jorge Novo, Jessica Dillon, Inji Baek, Deyin Xing, Michael G. Conner, Max A. Cheng, Andres Matoso, Ya Chea Tsai, Hyeon Jin Park, Emily Farmer, Tzyy Choou Wu, Hung Tran, Kara Lombardo, Chien Fu Hung, Gloria Cheang, Wei Song, Russell Vang, Yuehua Liu
Publikováno v:
Hum Pathol
Using a comprehensive next-generation sequencing pipeline (143 genes), Oncomine Comprehensive v.2, we analyzed genetic alterations on a set of vulvar squamous cell carcinomas (SCCs) with emphasis on the primary and metastatic samples from the same pa
Autor:
George J. Netto, Isabela Werneck da Cunha, Maria Angelica Mendoza Rodriguez, Diana Taheri, Nickolas Papadopoulos, Kazutoshi Fujita, Christopher J. VandenBussche, Dilek Ertoy, Bert Vogelstein, Kenneth W. Kinzler, Yuxuan Wang, Doreen Nguyen, Morgan L. Cowan, Gunes Guner, Maria Del Carmen Rodriguez Pena, Isaac Kinde, Simeon Springer, Mathew T. Olson, Trinity J. Bivalacqua
Publikováno v:
Human Pathology. 53:8-13
TERT promoter mutations (TERT-mut) have been detected in 60% to 80% of urothelial carcinomas. A molecular urine-based screening assay for the detection of TERT-mut is currently being pursued by our group and others. A small but significant number of
Autor:
Minako Hirahashi, Yoshiteru Kumagae, Eiji Oki, Hidetaka Yamamoto, Yukiko Kohno, Yoshinao Oda, Masafumi Nakamura
Publikováno v:
Human Pathology. 52:145-152
The effects of oxidative stress in adenocarcinomas of gastric cardia (AGCs) have not been fully elucidated. With a strict definition of AGC, we examined the immunohistochemical expressions of inducible nitric oxide synthase; 8-hydroxy-deoxyguanosine;