Zobrazeno 1 - 10
of 19
pro vyhledávání: ''
Mantle cell lymphoma with chronic lymphocytic leukemia-like features: a diagnostic mimic and pitfall
Autor:
Pei Lin, Mahsa Khanlari, Francisco Vega, Lianqun Qiu, Sa A. Wang, Chi Young Ok, Shaoying Li, C. Cameron Yin, Jie Xu, Sophia Garces, L. Jeffrey Medeiros, Guilin Tang
Publikováno v:
Human Pathology. 119:59-68
Mantle cell lymphoma (MCL) is a mature B-cell neoplasm characterized by t(11;14)(q13;q32) and cyclin D1 overexpression in >95% of cases. Classic MCL cases are composed of a monotonous population of small to medium-sized lymphocytes with irregular nuc
Autor:
Mingming Yuan, Bei Wang, Rongrong Chen, Xuefeng Xia, Huang Chen, Dingrong Zhong, Jia Guo, Changxi Wang
Publikováno v:
Human Pathology. 114:90-98
Anaplastic lymphocyte kinase (ALK) rearrangement, a key oncogenic driver promoting the expression of ALK protein in tumor cells, is found in 2%-7% of patients with nonsmall cell lung cancer (NSCLC). ALK fusion is routinely determined with immunohisto
Autor:
Hailing Li, Ke Liang, Xiaotong Jing, Shuang Ge, Zhiqiang Zhou, Yan Wang, Jun Wang, Cuijuan Zhang, Shuyu Mei
Publikováno v:
Human Pathology. 84:309-320
Classical Hodgkin lymphoma (cHL) and ALK- anaplastic large cell lymphoma (ALCL) share many morphologic and immunohistochemical features, causing difficulties in differential diagnosis. Aberrant T-cell/B-cell antigen (TCA/BCA) expression in cHL/ALCL h
Autor:
Juliana Pereira, Jenna Weber, Shuchun Zhao, Benjamin A. Pinsky, Luis Alberto de Padua Covas Lage, Maria Claudia Nogueira Zerbini, Cristiane R. Ferreira, Malaya K. Sahoo, Yasodha Natkunam
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Summary Forkhead box P3 (FOXP3) is a specific marker for regulatory T-cells (Tregs). We report 6 cases of T-cell lymphomas with Treg phenotype based on diffuse positivity for FOXP3 in tumor cells. The patients showed a median age of 56 years with a m
Autor:
Jessica Van Ziffle, Linlin Wang, Nancy Y. Greenland, Yen-Chun Liu, Sonam Prakash, Zhongxia Qi
Publikováno v:
Human pathology. 108
Summary Myeloid sarcoma (MS) is a rare manifestation of acute myeloid leukemia (AML) characterized by extramedullary proliferation of myeloid blasts. Owing to the rarity of MS, the clonal evolution of cell populations giving rise to MS is not well un
Autor:
Yanming Zhang, Alain Mina, Lawrence J. Jennings, Jessica K. Altman, Juehua Gao, Kwang Youn Kim, Madina Sukhanova, Xinyan Lu, Yi Hua Chen
Publikováno v:
Human pathology. 98
Chromothripsis is a unique type of genomic instability and is recognized in various cancers. In myeloid neoplasms (MNs), chromothripsis was linked to poor prognosis and specific genetic alterations (complex karyotype, 5q deletions, and loss of TP53).
Publikováno v:
Human pathology. 86
p53 expression and MYC extra copies (MYC-EC) have been reported to serve as independent adverse prognostic markers in patients with diffuse large B-cell lymphoma (DLBCL). However, the impact of p53 expression in MYC-EC lymphomas has not been delineat
Autor:
Alexander Tzankov, L. Jeffrey Medeiros, Sa A. Wang, Kristy L. Richards, Zijun Y. Xu-Monette, Jonathan W. Said, Ken H. Young, Shanxiang Zhang, Shi Wang, Sylvia Hoeller
Publikováno v:
Human Pathology. 44:2658-2667
Composite lymphoma with follicular lymphoma (FL) and mantle cell lymphoma (MCL) components is rare and can pose a substantial diagnostic challenge. We report two cases of composite lymphoma with FL and MCL components occurring in lymph nodes. Both ca
Autor:
Marie-France Fassotte, Jacques Boniver, Maryse Baia, Philippe Gaulard, Laurence de Leval, Katty Delbecque, Bettina Bisig, Christiane Copie-Bergman
Publikováno v:
Human Pathology. 40:1504-1509
Summary The genetic alterations underlying extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue type are heterogeneous and show variation according to the tumor site. Here, we report a case of mucosa-associated lymphoid tiss
Autor:
Hadrian Szpurka, Jaroslaw P. Maciejewski, Beata Bak, Eric D. Hsi, Sarah Gibson, Andrew E. Schade
Publikováno v:
Human Pathology. 39:1111-1114
Abnormal nuclear megakaryocytic staining for phospho-STAT5 (pSTAT5) correlates with JAK2 V617F mutational status in non-chronic myelogenous leukemia chronic myeloproliferative disorders. However, a proportion of wild-type JAK2 non-chronic myelogenous