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Publikováno v:
Human Pathology. 81:148-156
Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is closely related to the occurrence and development of malignant tumors. This study discusses the expression of LETM1 in esophageal squamous cell carcinoma (ESCC) and its association
Publikováno v:
Human Pathology. 73:114-121
AT-rich interaction domain 4B (ARID4B), which belongs to the ARID family, is heavily involved in cell growth and differentiation and is closely associated with many types of tumors. However, the role of this protein in hepatocellular carcinoma (HCC)
Publikováno v:
Human Pathology. 68:103-111
Programmed cell death 1 receptor (PD-1)/programmed death-1 ligand-1 (PD-L1) interaction has been linked to tumor immune evasion. PD-L1 expression has been indicated in identifying non-small cell lung carcinoma (NSCLC) patients for treatment with anti
Autor:
Go Eun Bae, Kyu Yeoun Won, Jun Uk Lim, Sang-Hyun Kim, Sung Il Choi, Gou Young Kim, Sung-Jig Lim, Hyung Kyung Kim
Publikováno v:
Human Pathology. 68:112-118
The function and contribution of tumoral FOXP3 in gastric cancer development remain poorly understood. Thus, we studied the expression of tumoral FOXP3 and its relationship with the well-known tumor suppressor proteins P21 and P53 in gastric adenocar
Publikováno v:
Human Pathology. 68:69-78
MicroRNAs (miRNAs) are involved in regulation of epithelial-mesenchymal transition (EMT) during breast cancer progression. The purpose of this study was to analyze the clinicopathologic significance of expression of EMT-related miRNAs, miR-9 and miR-
Autor:
Daniel Neureiter, Christian Mayr, Pietro Di Fazio, Stefan Stättner, Romana Urbas, Tarkan Jäger, Eckhard Klieser, Florian Primavesi, Stefan Swierczynski, Klaus Holzmann, A. Dinnewitzer, Tobias Kiesslich
Publikováno v:
Human Pathology. 65:41-52
Epigenetic factors contribute to carcinogenesis, tumor promotion, and chemoresistance. Histone deacetylases (HDACs) are epigenetic regulators that primarily cause chromatin compaction, leading to inaccessibility of promoter regions and eventually gen
Autor:
Masahiro Shimokawa, Yuki Tanaka, Takeshi Iwasaki, Kenichi Kohashi, Shinichi Aishima, Huanlin Wang, Yoshihiko Maehara, Yukihiko Okumura, Tomoharu Yoshizumi, Yoshinao Oda
Publikováno v:
Human Pathology. 64:69-75
Spalt-like transcriptional factor 4 (SALL4), a stem marker, is reactivated in several cancers. A previous study has demonstrated that SALL4 interacts with the nucleosome remodeling deacetylase complex, which contains histone deacetylase 1 (HDAC1) and
Autor:
Katie S. Nason, Jon M. Davison, Changqing Ma, Reetesh K. Pai, Brett M. Lowenthal, James D. Luketich, Arjun Pennathur
Publikováno v:
Human pathology. 94
Esophageal adenocarcinoma often presents at an advanced stage and has a dismal prognosis. Current prognostic markers have limited utility. ARID1A is implicated as a tumor suppressor gene in esophageal adenocarcinoma. Loss of ARID1A expression correla
Autor:
Minako Hirahashi, Yoshiteru Kumagae, Eiji Oki, Hidetaka Yamamoto, Yukiko Kohno, Yoshinao Oda, Masafumi Nakamura
Publikováno v:
Human Pathology. 52:145-152
The effects of oxidative stress in adenocarcinomas of gastric cardia (AGCs) have not been fully elucidated. With a strict definition of AGC, we examined the immunohistochemical expressions of inducible nitric oxide synthase; 8-hydroxy-deoxyguanosine;
Autor:
Yuling Dong, Feng Li, Jinfang Jiang, Wei Jia, Lijuan Pang, Lin Tao, Yan Ren, Weihua Liang, Xiang-Lin Yuan, Gang Cheng, Wen Jie Zhang
Publikováno v:
Human Pathology. 50:162-169
Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) is ubiquitously expressed in numerous tissues and is activated by various extracellular stimuli to regulate processes, such as cell proliferation and differentiation. Recent studies have ident