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Autor:
Alexandra Legge, Kirsten E. Fleming, Daniel Gaston, Thai Yen Ly, Sylvia Pasternak, Michael D. Carter, Noreen M. Walsh, Ryan C. DeCoste
Publikováno v:
Human Pathology. 117:31-41
Summary Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma. Oncogenesis occurs via Merkel cell polyomavirus–mediated (MCPyV+) and/or ultraviolet radiation–associated (MCPyV−) pathways. Advanced clinical stage a
Autor:
Yue Xu, Na Li, Juntao Ge, Qiang Liu, Shuai Liu, Zuohui Zhao, Zunsong Wang, Xiaoqing Yang, Jiaju Lu, Yijiao Yuan, Hongyi Qu
Publikováno v:
Human pathology. 80
Summary The antioxidant enzyme manganese superoxide dismutase (MnSOD) is up-regulated in renal cell carcinoma (RCC) and has been implicated in multiple stages of RCC tumorigenesis and progression. However, the prognostic significance of MnSOD in RCC
Autor:
Qunying Wu, Shuanlong Che, Yang Yang, Zhenhua Lin, Nan Li, Liyan Chen, Tiefeng Jin, Yunze Nan
Publikováno v:
Human pathology. 75
T lymphoma invasion and metastasis 1 (Tiam1), a guanine nucleotide exchange factor, is involved in the tumorigenesis of a number of malignancies. This study was aimed to explore the role of Tiam1 in cervical cancer progression, and evaluate the progn
Publikováno v:
Human Pathology. 46:1006-1014
This study aimed to evaluate the expression of H2B monoubiquitination enzyme (uH2B) and ubiquitin-specific protease enzyme 22 (USP22) in colon carcinoma and establish a correlation between the expression of these enzymes and clinicopathological param
Autor:
Lili Zhao, Nallasivam Palanisamy, Timothy M. Johnson, Douglas R. Fullen, Heather Chubb, Paul W. Harms, Christopher K. Bichakjian, Shannon Carskadon, Kelly L. Harms
Publikováno v:
Human pathology. 67
Summary Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that affects tumorigenesis by epigenetic gene silencing. Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine carcinoma that has a high risk of disease progression wi
Publikováno v:
Human Pathology. 44:2020-2027
Growing evidence suggests that phospholipase A2 (PLA2) plays a pivotal role in tumorigenesis in human gastrointestinal cancer. One of the well-studied isoforms of PLA2, group IIA PLA2 (PLA2G2A), appears to exert its protumorigenic or antitumorigenic
Publikováno v:
Human Pathology. 43:557-566
Most Merkel cell carcinomas display pure neuroendocrine differentiation (pure Merkel cell carcinoma), whereas a minority show combined neuroendocrine and nonneuroendocrine elements (combined Merkel cell carcinoma). Recent identification of Merkel cel
Autor:
Dongcai Liu, Zhu-lin Yang
Publikováno v:
Human Pathology. 42:1676-1683
Gallbladder cancers are aggressive tumors with a poor prognosis and high mortality rate. To find specific biological markers for early diagnosis and prognosis and to develop possible alternative treatment strategies, we examined minichromosome mainte
Autor:
Sandra Parenti, Francesco Rivasi, Sergio Ferrari, Alexis Grande, Lorena Losi, Fabrizio Ferrarini, Margherita Gavioli, Gianni Natalini
Publikováno v:
Human Pathology. 42:960-971
We have previously reported that treatment of colorectal cancer cells with mesalazine results in the up-regulated expression of a novel member of the cadherin protein superfamily, named μ-protocadherin, which is able to sequester β-catenin on plasm
Autor:
Sylvia L. Asa, Ryohei Katoh, Tadao Nakazawa, Tetsuo Kondo, Shin-ichi Murata, Shereen Ezzat, Junichi Kurebayashi
Publikováno v:
Human Pathology. 38:1810-1818
BRAF (7q24) encodes a serine/threonine protein kinase, and its expression level varies in different tissues. Although a high prevalence of BRAF mutation has been suggested as an important event in thyroid tumorigenesis, little is known about the expr