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Publikováno v:
Human Pathology. 119:51-58
Oncogenic mutations in the adenomatous polyposis coli (APC)/Wnt signaling pathway are well documented. The FBXW7 gene (F-box and WD repeat domain-containing 7) encodes a member of the ubiquitin-proteasome complex that is more recently described to an
Mantle cell lymphoma with chronic lymphocytic leukemia-like features: a diagnostic mimic and pitfall
Autor:
Pei Lin, Mahsa Khanlari, Francisco Vega, Lianqun Qiu, Sa A. Wang, Chi Young Ok, Shaoying Li, C. Cameron Yin, Jie Xu, Sophia Garces, L. Jeffrey Medeiros, Guilin Tang
Publikováno v:
Human Pathology. 119:59-68
Mantle cell lymphoma (MCL) is a mature B-cell neoplasm characterized by t(11;14)(q13;q32) and cyclin D1 overexpression in >95% of cases. Classic MCL cases are composed of a monotonous population of small to medium-sized lymphocytes with irregular nuc
Autor:
Alexandra Legge, Kirsten E. Fleming, Daniel Gaston, Thai Yen Ly, Sylvia Pasternak, Michael D. Carter, Noreen M. Walsh, Ryan C. DeCoste
Publikováno v:
Human Pathology. 117:31-41
Summary Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma. Oncogenesis occurs via Merkel cell polyomavirus–mediated (MCPyV+) and/or ultraviolet radiation–associated (MCPyV−) pathways. Advanced clinical stage a
Autor:
Mingming Yuan, Bei Wang, Rongrong Chen, Xuefeng Xia, Huang Chen, Dingrong Zhong, Jia Guo, Changxi Wang
Publikováno v:
Human Pathology. 114:90-98
Anaplastic lymphocyte kinase (ALK) rearrangement, a key oncogenic driver promoting the expression of ALK protein in tumor cells, is found in 2%-7% of patients with nonsmall cell lung cancer (NSCLC). ALK fusion is routinely determined with immunohisto
Autor:
Vassiliki Kotoula, Helen Sgouramali, Stavroula Pervana, Kyriakos Chatzopoulos, Georgia-Angeliki Koliou, George Pentheroudakis, Georgia Kafiri, Dimitrios Pectasides, Pavlos Papakostas, Vasilios Karavasilis, Elissavet Pazarli, George Fountzilas, Sofia Chrisafi, Prodromos Hytiroglou, Georgios Tsoulfas, Eleni Giannoulatou, Kyriaki Papadopoulou
Publikováno v:
Human Pathology. 107:104-116
Although primary colorectal carcinomas (CRCs) frequently share genetic alterations with their metastases, morphologic surrogates reflecting the genotype contexture of metastases remain largely unknown. We investigated phenotype/genotype associations
Autor:
Lodewijk A.A. Brosens, Antonio Pea, Andrea Mafficini, Rita T. Lawlor, Aldo Mombello, Michele Milella, Guido Mazzoleni, Matteo Fassan, Claudio Luchini, Davide Antonello, Gaetano Paolino, Sonia Grimaldi, Nicola Sperandio, Giulio Riva, Giuseppe Malleo, Anna Tomezzoli, Esther Hanspeter, Susanna L. Cooke, Giovanni de Manzoni, Philip A. Beer, Alessia Nottegar, Cinzia Cantù, Borislav Rusev, Roberto Salvia, Nicola Silvestris, Concetta Sciammarella, Aldo Scarpa, Giada Bonizzato, Maria Bencivenga, Giovanni Marchegiani, Liang Cheng, Serena Pedron, Maria L. Piredda, Paola Mattiolo, Volkan Adsay
Publikováno v:
Human Pathology, 118, 30-41
Human Pathology, 118, pp. 30-41
Human Pathology, 118, pp. 30-41
Summary Hepatoid tumors (HT) are rare neoplasms morphologically resembling hepatocellular carcinoma, which arise in several organs other than the liver. A comprehensive molecular profile of this group of neoplasms is still lacking. Genomic characteri
Autor:
Kenji Suzuki, Yoshiyuki Suehara, Tsuyoshi Saito, Kazuya Takamochi, Kazuhisa Takahashi, Fumiyuki Takahashi, Kei Sano, Kieko Hara, Takuo Hayashi, Satsuki Kishikawa, Takashi Yao, Shinji Kohsaka
Publikováno v:
Human Pathology. 103:42-51
Summary The extensive clinical applications of next-generation sequence analyzers have made uncommon and compound EGFR mutations more prevalent than previously described. However, clinicopathological impacts of compound EGFR mutations in lung adenoca
Autor:
Petr Steiner, Alena Skálová, Petr Martinek, Martina Baněčková, Andrle Pavel, Thalita Santana, Petr Grossmann
Publikováno v:
Human Pathology. 93:37-47
Summary Salivary duct carcinoma (SDC) is one of the most aggressive salivary gland tumors, and prognosis remains poor for most patients. The aim of this study was to investigate the prognostic implications of biomarker immunoprofile in a cohort of SD
Autor:
Roman Carlos, Thayná Melo de Lima Morais, Oslei Paes de Almeida, Manoela Domingues Martins, Ciro Dantas Soares, Albina Altemani, Fernanda Viviane Mariano
Publikováno v:
Human Pathology. 92:59-66
Mammaglobin is expressed in breast and salivary gland secretory carcinomas; however, its expression in salivary duct carcinomas (SDCs) still not well established. Therefore, the aim of this study was to investigate the presence and distribution of ma
Publikováno v:
Human pathology. 116
Metastatic breast carcinomas (BCs) with phenotype of triple-negative (TNBC) or low hormonal receptor levels [estrogen receptor (ER)/progesterone receptor (PR) 10% and HER2-] are mainly treated with cytotoxic chemotherapy. Targeting androgen receptor