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Publikováno v:
Human Pathology. 119:51-58
Oncogenic mutations in the adenomatous polyposis coli (APC)/Wnt signaling pathway are well documented. The FBXW7 gene (F-box and WD repeat domain-containing 7) encodes a member of the ubiquitin-proteasome complex that is more recently described to an
Autor:
Alexandra Legge, Kirsten E. Fleming, Daniel Gaston, Thai Yen Ly, Sylvia Pasternak, Michael D. Carter, Noreen M. Walsh, Ryan C. DeCoste
Publikováno v:
Human Pathology. 117:31-41
Summary Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma. Oncogenesis occurs via Merkel cell polyomavirus–mediated (MCPyV+) and/or ultraviolet radiation–associated (MCPyV−) pathways. Advanced clinical stage a
Autor:
Mingming Yuan, Bei Wang, Rongrong Chen, Xuefeng Xia, Huang Chen, Dingrong Zhong, Jia Guo, Changxi Wang
Publikováno v:
Human Pathology. 114:90-98
Anaplastic lymphocyte kinase (ALK) rearrangement, a key oncogenic driver promoting the expression of ALK protein in tumor cells, is found in 2%-7% of patients with nonsmall cell lung cancer (NSCLC). ALK fusion is routinely determined with immunohisto
Autor:
Lodewijk A.A. Brosens, Antonio Pea, Andrea Mafficini, Rita T. Lawlor, Aldo Mombello, Michele Milella, Guido Mazzoleni, Matteo Fassan, Claudio Luchini, Davide Antonello, Gaetano Paolino, Sonia Grimaldi, Nicola Sperandio, Giulio Riva, Giuseppe Malleo, Anna Tomezzoli, Esther Hanspeter, Susanna L. Cooke, Giovanni de Manzoni, Philip A. Beer, Alessia Nottegar, Cinzia Cantù, Borislav Rusev, Roberto Salvia, Nicola Silvestris, Concetta Sciammarella, Aldo Scarpa, Giada Bonizzato, Maria Bencivenga, Giovanni Marchegiani, Liang Cheng, Serena Pedron, Maria L. Piredda, Paola Mattiolo, Volkan Adsay
Publikováno v:
Human Pathology, 118, 30-41
Human Pathology, 118, pp. 30-41
Human Pathology, 118, pp. 30-41
Summary Hepatoid tumors (HT) are rare neoplasms morphologically resembling hepatocellular carcinoma, which arise in several organs other than the liver. A comprehensive molecular profile of this group of neoplasms is still lacking. Genomic characteri
Autor:
Roman Carlos, Thayná Melo de Lima Morais, Oslei Paes de Almeida, Manoela Domingues Martins, Ciro Dantas Soares, Albina Altemani, Fernanda Viviane Mariano
Publikováno v:
Human Pathology. 92:59-66
Mammaglobin is expressed in breast and salivary gland secretory carcinomas; however, its expression in salivary duct carcinomas (SDCs) still not well established. Therefore, the aim of this study was to investigate the presence and distribution of ma
Autor:
Ying-Bei Chen, Deborah DeLair, Paolo Cotzia, Chad M. Vanderbilt, Jinjuan Yao, Marc Ladanyi, Dara S. Ross, Jason C. Chang, Laura H. Tang, Javier A. Arias Stella, Sounak Gupta
Publikováno v:
Hum Pathol
As immune checkpoint inhibitors are rapidly developing into the standard of care for patients with advanced melanoma, the value of diagnostic metrics to predict response to immunotherapy is steadily increasing. Next-generation sequencing based parame
Autor:
José A. Galván, Sara N. Meyer, Heather Dawson, Alessandro Lugli, Inti Zlobec, Stefan Zahnd, Lena Sokol
Publikováno v:
Human Pathology. 87:18-27
Tumor buds in colorectal cancer are hypothesized to undergo a (partial) epithelial-mesenchymal transition (EMT). If so, cytokeratin (CK) and vimentin (VIM) co-expression is expected. CK+/VIM+ can also be found in some stromal cells; however, their or
Publikováno v:
Human Pathology. 86:108-114
Triple-negative and HER2-positive breast cancers (BCs) are more aggressive than hormone receptor-positive/HER2-negative BCs and show higher levels of tumor-infiltrating lymphocytes (TILs) and PD-L1 expression. Recently, US Food and Drug Administratio
Autor:
Mark D. Ewalt, Lily L. Lai, Jing Zhai, Marta Invernizzi, Elizabeth Y. Zhang, Gabriel Giannini, Joyce C. Niland
Publikováno v:
Human Pathology. 86:85-92
Summary Metaplastic breast carcinoma (MBC) is a rare subtype of breast cancer with variable morphology. MBC is more often triple negative (ER−, PR−, HER2−) and is associated with poorer clinical outcome when compared with infiltrating ductal ca
Autor:
Hailing Li, Ke Liang, Xiaotong Jing, Shuang Ge, Zhiqiang Zhou, Yan Wang, Jun Wang, Cuijuan Zhang, Shuyu Mei
Publikováno v:
Human Pathology. 84:309-320
Classical Hodgkin lymphoma (cHL) and ALK- anaplastic large cell lymphoma (ALCL) share many morphologic and immunohistochemical features, causing difficulties in differential diagnosis. Aberrant T-cell/B-cell antigen (TCA/BCA) expression in cHL/ALCL h