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Autor:
Mingming Yuan, Bei Wang, Rongrong Chen, Xuefeng Xia, Huang Chen, Dingrong Zhong, Jia Guo, Changxi Wang
Publikováno v:
Human Pathology. 114:90-98
Anaplastic lymphocyte kinase (ALK) rearrangement, a key oncogenic driver promoting the expression of ALK protein in tumor cells, is found in 2%-7% of patients with nonsmall cell lung cancer (NSCLC). ALK fusion is routinely determined with immunohisto
Autor:
Vassiliki Kotoula, Helen Sgouramali, Stavroula Pervana, Kyriakos Chatzopoulos, Georgia-Angeliki Koliou, George Pentheroudakis, Georgia Kafiri, Dimitrios Pectasides, Pavlos Papakostas, Vasilios Karavasilis, Elissavet Pazarli, George Fountzilas, Sofia Chrisafi, Prodromos Hytiroglou, Georgios Tsoulfas, Eleni Giannoulatou, Kyriaki Papadopoulou
Publikováno v:
Human Pathology. 107:104-116
Although primary colorectal carcinomas (CRCs) frequently share genetic alterations with their metastases, morphologic surrogates reflecting the genotype contexture of metastases remain largely unknown. We investigated phenotype/genotype associations
Autor:
Kenji Suzuki, Yoshiyuki Suehara, Tsuyoshi Saito, Kazuya Takamochi, Kazuhisa Takahashi, Fumiyuki Takahashi, Kei Sano, Kieko Hara, Takuo Hayashi, Satsuki Kishikawa, Takashi Yao, Shinji Kohsaka
Publikováno v:
Human Pathology. 103:42-51
Summary The extensive clinical applications of next-generation sequence analyzers have made uncommon and compound EGFR mutations more prevalent than previously described. However, clinicopathological impacts of compound EGFR mutations in lung adenoca
Autor:
Anna Sebestyén, Yanyan Lou, Judit Pápay, Tracy L. Majewicz, Ildikó Krencz, Andras Khoor, Gabrielle F. Lutz
Publikováno v:
Human Pathology. 93:74-80
Small cell lung carcinoma (SCLC) accounts for approximately 15% of all lung cancers and remains a challenging disease, with no significant improvement in the field of targeted therapies. The RICTOR gene (rapamycin-insensitive companion of mTOR [mamma
Autor:
Roman Carlos, Thayná Melo de Lima Morais, Oslei Paes de Almeida, Manoela Domingues Martins, Ciro Dantas Soares, Albina Altemani, Fernanda Viviane Mariano
Publikováno v:
Human Pathology. 92:59-66
Mammaglobin is expressed in breast and salivary gland secretory carcinomas; however, its expression in salivary duct carcinomas (SDCs) still not well established. Therefore, the aim of this study was to investigate the presence and distribution of ma
Autor:
Hailing Li, Ke Liang, Xiaotong Jing, Shuang Ge, Zhiqiang Zhou, Yan Wang, Jun Wang, Cuijuan Zhang, Shuyu Mei
Publikováno v:
Human Pathology. 84:309-320
Classical Hodgkin lymphoma (cHL) and ALK- anaplastic large cell lymphoma (ALCL) share many morphologic and immunohistochemical features, causing difficulties in differential diagnosis. Aberrant T-cell/B-cell antigen (TCA/BCA) expression in cHL/ALCL h
Publikováno v:
Human Pathology. 81:166-175
Aberrant Wnt signaling is a hallmark of solid pseudopapillary neoplasms (SPNs) of the pancreas. Transcription factor E3 (TFE3) plays a critical role in activation and regulation of the Wnt pathway and is predicted to be a candidate gene implicated in
Autor:
Seong Jin Cho, Eun Sook Nam, Mi Jung Kwon, Jinwon Seo, Mineui Hong, Ji-Young Choe, Hye-Rim Park, Soo Kee Min, Eun Soo Kim, Bumjung Park, Kyueng-Whan Min, Young Soo Rho
Publikováno v:
Human Pathology. 80:28-39
Programmed cell death-1 ligand-1 (PD-L1), essential for immune evasion, is a potential candidate for pathogenesis and therapeutic target of human papillomavirus (HPV)-positive tonsillar squamous cell carcinomas (TSCCs). MET/hepatocyte growth factor s
Autor:
Juliana Pereira, Jenna Weber, Shuchun Zhao, Benjamin A. Pinsky, Luis Alberto de Padua Covas Lage, Maria Claudia Nogueira Zerbini, Cristiane R. Ferreira, Malaya K. Sahoo, Yasodha Natkunam
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Summary Forkhead box P3 (FOXP3) is a specific marker for regulatory T-cells (Tregs). We report 6 cases of T-cell lymphomas with Treg phenotype based on diffuse positivity for FOXP3 in tumor cells. The patients showed a median age of 56 years with a m
Autor:
Jessica Van Ziffle, Linlin Wang, Nancy Y. Greenland, Yen-Chun Liu, Sonam Prakash, Zhongxia Qi
Publikováno v:
Human pathology. 108
Summary Myeloid sarcoma (MS) is a rare manifestation of acute myeloid leukemia (AML) characterized by extramedullary proliferation of myeloid blasts. Owing to the rarity of MS, the clonal evolution of cell populations giving rise to MS is not well un