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pro vyhledávání: '"Kevin J Harrington"'
Autor:
Robin Prestwich, Alan Melcher, Kevin J. Harrington, Hardev Pandha, Richard G. Vile, Rosa Maria Diaz, Fiona Errington
Publikováno v:
Human Gene Therapy. 20:1119-1132
The three-way interaction between oncolytic viruses, the tumor microenvironment, and the immune system is critical to the outcome of antitumor therapy. Classically, the immune system is thought to limit the efficacy of therapy, leading to viral clear
Autor:
Marka R. Crittenden, Nicholas R. Lemoine, Kevin J. Harrington, Georges Vassaux, Luis Álvarez-Vallina, Michael J. Gough, Rosa Maria Diaz, Richard G. Vile, Heung Chong
Publikováno v:
Human gene therapy. 13(11)
Systemic administration of currently manufactured viral stocks has not so far achieved sufficient circulating titers to allow therapeutic targeting of metastatic disease. This is due to low initial viral titers, immune inactivation, nonspecific adhes