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Publikováno v:
Histopathology. 79:1087-1098
Background and aims Proliferation is an important indicator of breast cancer (BC) prognosis, but is assessed using different approaches. Not all cells in the cell cycle are committed to division. This study aimed to characterise quantitative differen
Publikováno v:
Histopathology. 77:314-320
Aims Treatment with a BRAF inhibitor, alone or in combination with a MEK inhibitor, may be considered for BRAF-mutant anaplastic thyroid carcinoma (ATC). The purpose of this study was to characterise the histology of BRAF V600E-mutant ATC. Methods an
Autor:
Bradley A. Stohr, Soo-Jin Cho, Gregory R. Bean, Megan L. Troxell, Nicole A. Croom, Emily Chan, Karuna Garg, John P. Higgins
Publikováno v:
Histopathology. 76:1084-1090
Aims Metanephric adenomas (MAs) are conventionally regarded as rare renal tumours with indolent behaviour; limited case reports have described MAs with aggressive features. Conventional MAs harbour hotspot BRAF V600E mutations. A BRAF V600E senescenc
Publikováno v:
Histopathology. 76:366-374
Aims Colorectal carcinomas (CRC) with mismatch repair (MMR) deficiency have increased tumour mutation burden and respond to immune check-point inhibitor therapy. The Cancer Genome Atlas identified hypermutated CRCs with somatic mutations in DNA polym
Autor:
Francisco García-García, Ana Conesa, Rosa Carbonell-Muñoz, Pablo Conesa-Zamora, José García-Solano, María Del Carmen Turpin-Sevilla, Daniel Torres-Moreno
Publikováno v:
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria
instname
DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria
Aims To discern the differences in expression profiling of two histological subtypes of colorectal carcinoma (CRC) arising from the serrated route (serrated adenocarcinoma (SAC) and CRC showing histological and molecular features of a high level of m
Publikováno v:
Histopathology.
Aims Methylthioadenosine phosphorylase (MTAP) immunohistochemical expression is a specific marker of CDKN2A deletion in malignant mesothelioma. However, the relationship of MTAP expression with MTAP copy number remains unexplored. Methods and results
Autor:
Yoshinori Hasegawa, Yasushi Yatabe, Hiromichi Ebi, Yoshitsugu Horio, Yuko Hayashi, Toyoaki Hida, Chiaki Kondoh
Publikováno v:
Histopathology. 75:20-28
Aims Anaplastic lymphoma kinase (ALK) immunohistochemistry has shifted from being a screening tool to being a sole determinant for ALK-targeted therapy. Recent articles have referred to small-cell lung cancer (SCLC) transformation as a resistance mec
Autor:
Shinichi Aishima, Makiko Adachi, Koutaro Yamaji, Hirokazu Noshiro, Keita Kai, Atsushi Kawaguchi, Takao Ide
Publikováno v:
Histopathology. 75:63-73
AIM Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality worldwide. An excess of iron in liver tissue causes oxidative stress, leading to hepatocellular carcinogenesis. Iron metabolism, which is regulated by a complex mechan
Publikováno v:
Histopathology. 74:567-577
Aims Phyllodes tumours (PTs) of the breast are uncommon fibroepithelial neoplasms with the potential to recur and metastasise. Apart from histological grading, the expression of biological markers and its relationship with tumour behaviour have been
Autor:
Tadashi Yoshino, Yoshinobu Maeda, Tomoko Miyata-Takata, Yasuharu Sato, Katsuyoshi Takata, Tomohiro Toji, Shih Sung Chuang
Publikováno v:
Histopathology. 73:1030-1038
Aims Although the neoplastic cells of extranodal natural killer (NK)/T-cell lymphoma (ENKTL) usually do not express T-cell antigens, the T-cell receptor (TCR) gene might be rearranged and TCR protein expressed. The aim is to elucidate the expression