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Autor:
Tadashi Yoshino, Yoshinobu Maeda, Tomoko Miyata-Takata, Yasuharu Sato, Katsuyoshi Takata, Tomohiro Toji, Shih Sung Chuang
Publikováno v:
Histopathology. 73:1030-1038
Aims Although the neoplastic cells of extranodal natural killer (NK)/T-cell lymphoma (ENKTL) usually do not express T-cell antigens, the T-cell receptor (TCR) gene might be rearranged and TCR protein expressed. The aim is to elucidate the expression
Autor:
Pakitapillil S Dhanaraj, Seema Sen, Abhishek Kumar, Sameeksha Yadav, Tanaya Bhattacharya, Mansi Verma, Varsha Chhoker, Perumal Jayaraj, Kameshwar Sharma Yadavilli, Juhi Arora
Publikováno v:
Histopathology. 69:268-275
Aims Sebaceous gland carcinoma (SGC) is a malignancy associated with the pilosebaceous unit, and occurs at ocular or non-ocular sites. Cyclooxygenases (COXs) are enzymes that are crucial for lipid metabolism. COX-2 is overexpressed in various cancers
Autor:
Jorge Sierra, Jaime Prat, Inigo Espinosa, Carmen Vergara, Eva Alvarez, Javier Briones, Juliana Villa, Esther Moga, Ramon Bordes, Julio Delgado
Publikováno v:
Histopathology. 54:478-485
AIMS In T cells, protein kinase C (PKC) theta plays a major role in T-cell receptor (TCR)-mediated activation of a novel nuclear factor (NF)-kappaB pathway that involves phosphorylation of p65 at serine 536 (Pp65(Ser536)). Bcl-10 acts along the same
Autor:
W. Glenn McCluggage, Manuel Salto-Tellez, Perry Maxwell, Stephen P Dobbs, Patricia A Higgins, Aidan Brady
Publikováno v:
Histopathology. 64(5)
Aims Adult granulosa cell tumours (AGCTs) are uncommon ovarian sex cord–stromal tumours which recur following surgical removal in up to 50% of patients. Treatment options for recurrent and advanced stage AGCTs are limited, with poor response to che
Publikováno v:
Histopathology. 25:247-252
c-erbB-3 protein expression was investigated immunohistochemically in a series of 97 malignant breast tumours using the monoclonal antibody RTJ1. Twenty-eight cases (28.8%) showed c-erbB-3 overexpression, 31 cases (32%) showed normal levels of c-erbB
Autor:
Odette Boutross-Tadross, Mernoosh Faghih, Warren G. Foster, Miguel A. Dominguez, Laurie Elit, Rami Elias
Publikováno v:
Histopathology. 54(7)
Autor:
Theodore Petsas, Chrisoula D. Scopa, Athanasios G. Papavassiliou, Anna Liava, Athanassios C. Tsamandas, Anna G. Antonacopoulou, Haralambos P. Kalofonos
Publikováno v:
Histopathology. 53(6)
Aims: Receptor tyrosine kinases epidermal growth factor receptor (EGFR) and HER-2 and cyclooxygenase-2 (COX-2) are promising molecular targets for cancer therapy and/or prevention. The aim was to evaluate EGFR, HER-2 and COX-2 mRNA and protein expres
Autor:
Mamoun Younes, Futoshi Akiyama, Nobuhiro Harada, Kaiyo Takubo, Takayuki Hosoi, Noriko Yoshimura, Motoji Sawabe, Naoko Honma, Tomio Arai, Fujio Kasumi, Goi Sakamoto
Publikováno v:
Histopathology. 50(4)
AIMS Apocrine carcinoma of the breast seldom expresses oestrogen receptors (ER) or progesterone receptors (PR), but frequently expresses androgen receptors (AR). Because of this unusual hormone receptor status, it has been suggested that oestrogens h
Autor:
Lydia Nakopoulou, Eleni Mylona, M Kamberou, Alexandros Nomikos, Issidora S. Papassideri, A. Keramopoulos, Christina Magkou
Publikováno v:
Histopathology. 50(3)
AIMS To investigate the clinicopathological and prognostic significance of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-9 proteins expression in invasive breast carcinoma and their relationship to tumour proliferation and expression of
Autor:
Ricardo Paniagua, Mónica Ricote, Ignacio García-Tuñón, Benito Fraile, Mar Royuela, Antonio Ruiz
Publikováno v:
Histopathology. 47(1)
Aims : To characterize the expression pattern of IL-6 and its receptors (IL-6Rα and gp130), to relate this pattern to bcl-2 and bax expression and to elucidate the effects on the proliferation/apoptosis equilibrium in benign conditions and in situ a