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Autor:
Joy Ardill, A.B. Atkinson, K. Pogue, C.F. Russell, Brian T. Johnston, I.S. Cadden, R. Connolly, Ann McGinty, D McCance
Publikováno v:
Histopathology. 51:743-751
Aims: Phaeochromocytomas are rare but potentially life-threatening neuroendocrine tumours of the adrenal medulla or sympathetic nervous system ganglia. There are no histological features which reliably differentiate benign from malignant phaeochromoc
Low rate of apoptosis and overexpression of bcl-2 in Epstein?Barr virus-associated gastric carcinoma
Autor:
K Oshima, Y. Yamashita, Takayuki Shirakusa, Masahiro Kikuchi, T. Shinohara, H Takeo, Tohru Kume
Publikováno v:
Histopathology. 34:502-509
Aims Epstein–Barr virus (EBV) has been demonstrated in about 10% of gastric carcinomas. However, the pathogenetic role of EBV in gastric carcinoma is uncertain. We compared the rate of apoptotic cell death, cell proliferation and the expression of
Publikováno v:
Histopathology. 33:117-122
Aims We investigated the significance of apoptosis, using the terminal deoxynucleotidyl transferase mediated dUTP-digoxigenin nick end-labelling method, in nasopharyngeal carcinoma biopsy samples. Methods and results The apoptotic index (AI) in 50 na
Autor:
Massimo Rugge, Ermanno Ancona, Anna Parenti, Alberto Ruol, L. Bozzola, Y. Horng Shiao, Vito Ninfo
Publikováno v:
Histopathology. 31:430-435
Aims: An inverse correlation between bcl-2 and p53 expression has been reported in several types of epithelial tumour. The role of bcl-2 and p53 in the development of oesophageal squamous carcinoma has yet to be established. The expression of bcl-2 a
Publikováno v:
Histopathology. 29:159-163
The aim of this study was to examine the immunohistochemical expression of p53 and bcl-2 in Kaposi's sarcoma and relate this with proliferation index (as measured by MIB-1 staining) and clinicopathological subtypes. Twenty formalin-fixed, paraffin-em
Publikováno v:
Histopathology. 28:135-140
The expression of bcl-2 protein was studied by immunohistochemistry using a monoclonal antibody in 158 cases of transitional cell bladder tumours. The bcl-2 protein was expressed in basal cells in normal transitional epithelium and 68% of the transit
Autor:
Rodrigo Martino, Salut Brunet, Ramón Bordes, Javier Briones, Inigo Espinosa, Anna Sureda, Jaime Prat, Jordi Sierra
Publikováno v:
Histopathology. 53(4)
AIM To characterize the activation of the nuclear factor (NF)-kappaB pathway in diffuse large B-cell lymphoma (DLBCL) by immunohistochemistry. METHODS AND RESULTS Sixty-six DLBCLs treated with anthracycline-containing chemotherapy were evaluated with
Publikováno v:
Histopathology. 50(5)
Aims: To investigate the role of BNIP3, a 19-kDa interacting protein of the Bcl-2 family, alongside Bcl-2 in follicular lymphoma in comparison with reactive lymphoid hyperplasia. The results were compared with those from p53 and caspase-3 (apoptotic
Autor:
Ricardo Paniagua, Mónica Ricote, Ignacio García-Tuñón, Benito Fraile, Mar Royuela, Antonio Ruiz
Publikováno v:
Histopathology. 47(1)
Aims : To characterize the expression pattern of IL-6 and its receptors (IL-6Rα and gp130), to relate this pattern to bcl-2 and bax expression and to elucidate the effects on the proliferation/apoptosis equilibrium in benign conditions and in situ a
Autor:
Ioanna Giannopoulou, Michalopoulou A, A. Keramopoulos, Anastasia Tzonou, Lydia Nakopoulou, Davaris Ps, Andreas C. Lazaris
Publikováno v:
Histopathology. 34(4)
AIM A role for altered programmed cell death in cancer stems from the description of alterations on tumour-associated genes involved in the regulation of apoptosis such as p53 and bcl-2. The balance between the latter may have significant implication