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Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Medellín, Colombia
Autor:
Marcia Llacuachaqui, Jeffrey N. Weitzel, Steven A. Narod, Garrett P. Larson, Juan David Figueroa, Gonzalo Vásquez Palacio, Robert Royer, Song Li, Julián Esteban Londoño Hernández, Jorge Madrid, Mauricio Lema
Publikováno v:
Hereditary Cancer in Clinical Practice
Background Approximately 5% of all breast cancers can be attributed to a mutation in the BRCA1 or BRCA2 gene. The genetic component of breast cancer in Colombia has been, for the most part, studied on cases from the Bogota region. Five different foun
Autor:
Toomas Veidebaum, Jelena Aršavskaja, Aili Lilleorg, Krista Kaasik, Peeter Padrik, Andres Metspalu, Kristiina Tamboom, Mare Tekkel
Publikováno v:
Hereditary Cancer in Clinical Practice
Hereditary Cancer in Clinical Practice, Vol 8, Iss 1, p 4 (2010)
Hereditary Cancer in Clinical Practice, Vol 8, Iss 1, p 4 (2010)
Background The aim of this study was to identify BRCA1 and BRCA2 mutations in the Estonian population. We analyzed genetic data and questionnaire from 64 early-onset (< 45 y) breast cancer patients, 47 familial cases (patients with breast or ovarian
Autor:
Steven A. Narod
Publikováno v:
Hereditary Cancer in Clinical Practice
Hereditary Cancer in Clinical Practice, Vol 2, Iss 1, Pp 5-10 (2004)
Hereditary Cancer in Clinical Practice, Vol 2, Iss 1, Pp 5-10 (2004)
Options for the prevention of hereditary breast and ovarian cancer include screening, preventive surgery and chemoprevention. Screening studies with magnetic resonance imaging of the breast are promising but the technology is not widespread and MRI i
Autor:
Małgorzata Stawicka, K Jaworska, E. Marczyk, Ping Sun, A Jakubowska, Bohdan Górski, Tomasz Byrski, Tomasz Huzarski, D. Surdyka, Wojciech Wasowicz, Steven A. Narod, E. Kilar, Katarzyna Durda, Jacek Gronwald, Marek Szwiec, Jakub Lubiński
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 9, Iss Suppl 2, p A5 (2011)
Hereditary Cancer in Clinical Practice
Hereditary Cancer in Clinical Practice
It has not been established if dietary factors or nutritional supplements impact on the incidence of cancer in high-risk women. We randomised 1135 women with a BRCA1 mutation to 250 micrograms daily of elemental selenium as sodium selenite, or to pla
Autor:
Gillian Mitchell
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 10, Iss Suppl 2, p A1 (2012)
Hereditary Cancer in Clinical Practice
Hereditary Cancer in Clinical Practice
The role of the familial cancer clinic (FCC) is to provide a cancer risk assessment and appropriate cancer risk management advice, but there are certain groups of patients for whom there are no standard risk management guidelines. One such group is w
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 4, Iss 1, Pp 7-11 (2006)
Hereditary Cancer in Clinical Practice
Hereditary Cancer in Clinical Practice
Molecular diagnostics of hereditary breast and/or ovarian cancer is mainly based on detection of BRCA1 and BRCA2 germline mutations in suspected families. The aim of the study was to determine the frequency, age and geographical distribution in 130 S