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Publikováno v:
Hereditary Cancer in Clinical Practice
Background Little is known about the experience of young women who become aware of their parent’s BRCA1 or BRCA2 (BRCA) mutation status as adolescents or young adults. There is also currently a gap in the literature pertaining to those who are foun
Autor:
Morawski Antoni W, Anna Jakubowska, Cezary Cybulski, Katarzyna Kaczmarek, Tomasz Byrski, Jan Lubinski, Wojciech Marciniak, Oleg Oszurek, Tomasz Huzarski, Katarzyna Durda, Katarzyna Jaworska-Bieniek, Magdalena Muszyńska, Grzegorz Sukiennicki, Jacek Gronwald, Tadeusz Dębniak, Marcin Lener
Publikováno v:
Hereditary Cancer in Clinical Practice
The study was conducted to determine if serum copper level could be a useful marker for selection for control examinations and if serum copper level is a risk factor in developing cancer. Copper was quantitatively measured in diluted serum samples by
Autor:
Andrzej Pławski, Michalina Tomys, Ursula G. Froster, Marzena Jasinowska, Marzena Skrzypczak-Zielinska
Publikováno v:
Hereditary Cancer in Clinical Practice
Breast cancer is the most commonly occurring cancer among women. The disease frequently attacks women at a young age. The German population has been greatly affected by breast cancer with approximately 74,500 females and 600 males being diagnosed wit
Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Medellín, Colombia
Autor:
Marcia Llacuachaqui, Jeffrey N. Weitzel, Steven A. Narod, Garrett P. Larson, Juan David Figueroa, Gonzalo Vásquez Palacio, Robert Royer, Song Li, Julián Esteban Londoño Hernández, Jorge Madrid, Mauricio Lema
Publikováno v:
Hereditary Cancer in Clinical Practice
Background Approximately 5% of all breast cancers can be attributed to a mutation in the BRCA1 or BRCA2 gene. The genetic component of breast cancer in Colombia has been, for the most part, studied on cases from the Bogota region. Five different foun
Autor:
Tirzah Braz Petta Lajus, Lucymara Fassarela Agnez-Lima, Tom Walsh, Betina Menezes Albuquerque, Ana Rafaela de Souza Timoteo, Patrícia Cristina Pascoto de Moura, Carlos Cesar de Oliveira Ramos, Mary Claire King
Publikováno v:
Hereditary Cancer in Clinical Practice
Background Male breast cancer (MBC) is an uncommon disease that has been the focus of limited research. It is estimated that approximately 10% of men with breast cancer have a genetic predisposition, with BRCA2 being the most prevalent genetic mutati
Publikováno v:
Hereditary Cancer in Clinical Practice
Several susceptibility genes differentially impact on the lifetime risk for breast cancer. Technological advances over the past years have enabled the detection of genetic risk factors through high-throughput screening of large breast cancer case–c
Autor:
Kukatharmini Tharmaratnam, Emma Hurley, Anthony J. Maxwell, Anthony Howell, Anne Irene Hagen, Marit Muri Holmen, Mary Wilson, Yit Yoong Lim, Dafydd Gareth Evans, Pål Møller, Elaine F. Harkness
Publikováno v:
Hereditary Cancer in Clinical Practice
Evans, D G, Harkness, E F, Howell, A, Wilson, M, Hurley, E, Holmen, M M, Tharmaratnam, K U, Hagen, A I, Lim, Y, Maxwell, A J & Moller, P 2016, ' Intensive breast screening in BRCA2 mutation carriers is associated with reduced breast cancer specific and all cause mortality ', Hereditary cancer in clinical practice, vol. 14, 8 . https://doi.org/10.1186/s13053-016-0048-3, https://doi.org/10.1186/s13053-016-0048-3
Evans, D G, Harkness, E F, Howell, A, Wilson, M, Hurley, E, Holmen, M M, Tharmaratnam, K U, Hagen, A I, Lim, Y, Maxwell, A J & Moller, P 2016, ' Intensive breast screening in BRCA2 mutation carriers is associated with reduced breast cancer specific and all cause mortality ', Hereditary cancer in clinical practice, vol. 14, 8 . https://doi.org/10.1186/s13053-016-0048-3, https://doi.org/10.1186/s13053-016-0048-3
Background The addition of annual MRI screening to mammography has heightened optimism that intensive screening along with improved treatments may substantially improve life expectancy of women at high risk of breast cancer. However, survival data fr
Autor:
Antoni W. Morawski, Cezary Cybulski, Katarzyna Durda, Magdalena Muszyńska, Grzegorz Sukiennicki, Katarzyna Kaczmarek, Katarzyna Jaworska-Bieniek, Tomasz Byrski, Jan Lubinski, Oleg Oszurek, Wojciech Marciniak, Jacek Gronwald, Anna Jakubowska, Tomasz Huzarski, Tadeusz Dębniak, Marcin Lener, Tomasz Gromowski
Publikováno v:
Hereditary Cancer in Clinical Practice
Material and methods The study was performed in five groups. For four of them (cancers of the lung, larynx, colon, prostate) and matched healthy controls serum was collected before treatment but during diagnosis. Whereas for breast cancer group serum
Autor:
Toomas Veidebaum, Jelena Aršavskaja, Aili Lilleorg, Krista Kaasik, Peeter Padrik, Andres Metspalu, Kristiina Tamboom, Mare Tekkel
Publikováno v:
Hereditary Cancer in Clinical Practice
Hereditary Cancer in Clinical Practice, Vol 8, Iss 1, p 4 (2010)
Hereditary Cancer in Clinical Practice, Vol 8, Iss 1, p 4 (2010)
Background The aim of this study was to identify BRCA1 and BRCA2 mutations in the Estonian population. We analyzed genetic data and questionnaire from 64 early-onset (< 45 y) breast cancer patients, 47 familial cases (patients with breast or ovarian
Autor:
Arvīds Irmejs, Arnis Āboliņš, Jānis Gardovskis, Dagnija Kalniete, Edvīns Miklaševičs, Ilze Strumfa, Miki Nakazawa-Miklasevica
Publikováno v:
Hereditary Cancer in Clinical Practice
Background Hereditary triple-negative breast cancer patients have better recurrence-free survival than triple-negative sporadic ones. High expression of some of the miRNAs is related to worse overall and disease-free survival of triple-negative breas