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Autor:
Fudong Lv, Xiaoli Zhang, Ning Li, Ronghua Jin, Dexi Chen, Li Li, Kai Liu, Daojie Liu, Lifeng Liu
Publikováno v:
Hepatology. 56:1380-1390
Glypican-3 (GPC3) is a heparan sulfate proteoglycan that has an important role in cell growth and differentiation, and its function in tumorigenesis is tissue-dependent. In hepatocellular carcinoma (HCC), the overexpression of GPC3 has been demonstra
Autor:
Liu Yang, Anna Mae Diehl, Alessia Omenetti, Wing-Kin Syn, Alessandro Porrello, M. Eric Gershwin, Heather Francis, Steve S. Choi, Youngmi Jung, Rafal P. Witek, Marlyn J. Mayo, Gianfranco Alpini
Publikováno v:
Hepatology. 50:518-527
The mechanisms mediating hepatic accumulation of inflammatory cells in cholestatic liver disease remain enigmatic. Our thesis is that Hedgehog (Hh) pathway activation promotes hepatic accumulation of immune cells that interact with cholangiocytes. We
Autor:
Lirija Alili, Holger Steinbrenner, Roland Reinehr, Helmut Sies, Philippe L. Walter, Lars-Oliver Klotz, Bodo Speckmann
Publikováno v:
Hepatology. 48:1998-2006
Selenoprotein P (SeP), the major selenoprotein in plasma, is produced mainly by the liver, although SeP expression is detected in many organs. Recently, we reported stimulation of SeP promoter activity by the forkhead box transcription factor FoxO1a
Publikováno v:
Hepatology. 48:1632-1643
The farnesoid X receptor (FXR) is a nuclear receptor that plays key roles in hepatoprotection by maintaining the homeostasis of liver metabolism. FXR null mice display strong hepatic inflammation and develop spontaneous liver tumors. In this report,
Autor:
Terrence Town, Ardeshir Z. Hashmi, Wajahat Z. Mehal, Richard A. Flavell, Dawidson Assis Gomes, Azuma Watanabe, Abdallah Badou
Publikováno v:
Hepatology. 46:1509-1518
Apoptosis of hepatocytes results in the development of liver fibrosis, but the molecular signals mediating this are poorly understood. Degradation and modification of nuclear DNA is a central feature of apoptosis, and DNA from apoptotic mammalian cel
Autor:
Michael S. Madejczyk, James L. Boyer, Jin Young Lee, Carol J. Soroka, Na Li, Paul A. Dawson, Whitney V. Christian, Nazzareno Ballatori
Publikováno v:
Hepatology. 42:1270-1279
The cellular and subcellular localization and mechanism of transport of the heteromeric organic solute transporter (OST) OST-OST was examined in human and rodent epithelia. The two subunits of the transporter were expressed together in human small in
Autor:
Francesco Ramirez, Cindy Else, Antonio Benedetti, Stefania Saccomanno, Gianluca Svegliati-Baroni, Marcos Rojkind, Yutaka Inagaki, Ana Rosa Rincón-Sánchez
Publikováno v:
Hepatology. 42:343-352
A lcohol-induced liver fibrosis is multifactorial and involves local and systemic events. At the systemic level, multiple cytokines, including those involved in the acute phase response, play a role in the pathophysiology of the disease and contribut
Publikováno v:
Hepatology. 37:653-664
Limited proliferative capacity is a characteristic of most normal human cells and results in a growth-arrested state, called replicative senescence. Functional expression of the telomerase catalytic subunit (human telomerase reverse transcriptase; hT
Publikováno v:
Hepatology. 33:148-158
The expression of neurotrophins and neurotrophin receptors in non-neural tissue is related to tissue remodeling, differentiation, proliferation and migration of target cells. The literature yields contradictory results on neurotrophin and neurotrophi
Autor:
Sandrine Godichaud, Baptiste Couronné, Alexis Desmoulière, Jean Rosenbaum, Liliane Dubuisson, Stéphanie Krisa, Jean-Michel Mérillon
Publikováno v:
Hepatology. 31:922-931
Liver myofibroblasts are major actors in the development of liver fibrosis and cancer progression. There is a large interest in drugs that might deactivate these cells. Many studies have shown that the grapevine-derived polyphenol, trans-resveratrol,