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pro vyhledávání: ''
Autor:
Alessandro Martini, Luciano Giacomelli, Stella Blandamura, Rosario Marchese-Ragona, Ambrogio Fassina, Rocco Cappellesso, Gino Marioni, Elena Fasanaro, Giancarlo Ottaviano, Vincenza Guzzardo, Niccolò Favaretto
Publikováno v:
Headneck. 40(9)
BACKGROUND In epithelial-to-mesenchymal transition, epithelial cells lose their features, acquiring a mesenchymal-like phenotype. Nm23-H1 protein relates to tumor cells' metastatic potential, its low expression in carcinomas often meaning a poor prog
Autor:
Cristina García-Inclán, Virginia N. Cabal, Cristina Riobello, José Luis Llorente, Mario Hermsen, Sara Reda, Alejandro López-Hernández, Fernando López, Blanca Vivanco, Sira Potes-Ares
Publikováno v:
Headneck. 40(4)
Background Sinonasal cancer carries a poor prognosis, especially in recurrent stages, and it is a disease with very limited treatment options. Methods The expression of programmed death ligand-1 (PD-L1) as a marker for immunotherapy was evaluated in
Autor:
Kevin Kunzmann, Kolja Freier, Gerhard Dyckhoff, Dominik Horn, Dana Holzinger, Peter Plinkert, Jochen Hess, Christian Freudlsperger, Jürgen Hoffmann
Publikováno v:
Headneck. 39(12)
Background PIK3CA alterations have been shown to be a frequent event in oropharyngeal squamous cell cancer (SCC), especially in human papillomavirus (HPV)-related tumors. Methods Tissue microarrays (TMAs) were used to evaluate pAKT(Ser473)/(Thr308),
Publikováno v:
Headneck. 35(6)
Background. The clinical evolution of laryngeal squamous cell carcinoma (SCC) is undetectable with the current staging criteria. To more completely understand the biology of laryngeal SCC, we assessed the expression of the proteins B-cell-specific Mo
Autor:
Rui Celso Martins Mamede, Fabiano Pinto Saggioro, Achim A. Jungbluth, Giulio C. Spagnoli, Wilson A. Silva, José Raphael de Moura Campos Montoro, Luciano Neder Serafini, David Livingstone Alves Figueiredo, Marco Antônio Zago
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
BACKGROUND: Tumor markers are genes or their products expressed exclusively or preferentially in tumor cells and cancer-testis antigens (CTAs) form a group of genes with a typical expression pattern expressed in a variety of malignant neoplasms. CTAs
Publikováno v:
Headneck. 33(7)
Background The purpose of this study was to determine inhibitor of apoptosis (IAP) expression, its relationship with p53, and epigenetic change in oral carcinogenesis that remain to be elucidated. Methods We measured IAP and p53 expression in 44 oral
Autor:
Francisco Santaolalla, Agustín Martínez Ibargüen, Aitor Zabala, Javier Gil, Adolfo Varona, Itxaro Perez, Gorka Larrinaga, Jon Irazusta, Lorena Blanco
Publikováno v:
Headneck. 31(10)
Background. Involvement of peptidases in carci- nogenic processes of several tumor types has been investigated in recent years. Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide and accounts for more than 90% o
Autor:
Marina Schena, Santo Landolfo, Carlo Giordano, Massimiliano Garzaro, Massimo Rittà, Luigi Chiusa, Michele Mondini, Vincenzo Landolfo, Jasenka Mazibrada, Marco De Andrea, Giancarlo Pecorari
Publikováno v:
Headneck. 31(3)
Background. The aim of this study was to deter- mine whether the aberrant expression of cell-cycle or immune- response markers together with human papillomavirus (HPV) positivity impacts patient survival in different head and neck squamous cell carci
Autor:
Inga Wedemeyer, Thomas K. Hoffmann, Markus Molitor, Robert Semrau, Jens Peter Klussmann, Antje Weinell, Markus Stenner, Uta Drebber, Simon F. Preuss, Orlando Guntinas-Lichius
Publikováno v:
Headneck. 30(10)
Background. The epidermal growth factor recep- tor (EGFR) and the inhibitor of apoptosis protein survivin play im- portant roles in the regulation of cellular proliferation and survival in squamous cell carcinomas. Their correlation in oropharyngeal
Autor:
Fu-Min Fang, Chao-Cheng Huang, Hui-Ching Chuang, Chang-Han Chen, Chih-Ying Su, Hsuan-Ying Huang, Ching-Mei Chen, Chih-Yen Chien
Publikováno v:
Headneck. 30(6)
Background Osteopontin (OPN) is considered to be a tumor-related protein associated with tumor aggressiveness and metastasis. Methods Immunohistochemistry was used to study the clinical significance of OPN expression in T1 and T2 tongue cancers. Resu