Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gijs R. van den Brink"'
Autor:
Brian G. Feagan, Reena Khanna, Cyriel Y. Ponsioen, Gijs R. van den Brink, Krisztina B Gecse, Vipul Jairath, Simon Travis, Geert R. D'Haens, Mark Löwenberg, William J. Sandborn
Publikováno v:
Gut. 62:803-807
A biosimilar is a biological medicine that enters the market subsequent to expiration of the patent of an original reference product and its similarity to the reference medicine exhibits ‘no clinically meaningful differences in terms of quality, sa
Autor:
Sanne L. Rosekrans, Viljar Jaks, Maria Kasper, James C. H. Hardwick, Anja Uhmann, G. Johan A. Offerhaus, Marius A. van den Bergh Weerman, Gijs R. van den Brink, Hein W. Verspaget, Heidi Hahn, Daan W. Hommes, Rune Toftgård, Willemijn A. van Dop, Jarom Heijmans
Publikováno v:
Gut, 62(3), 348-357. BMJ Publishing Group
Gut, 62(3), 348-357
Gut
Gut, 62(3), 348-357
Gut
Objective In the intestine Hedgehog (Hh) signalling is directed from epithelium to mesenchyme and negatively regulates epithelial precursor cell fate. The role of Hh signalling in the oesophagus has not been studied in vivo. Here the authors examined
Autor:
Daniel W. Hommes, Pim J. Koelink, Maikel P. Peppelenbosch, Dick J. Richel, Eva Hoff, Jarom Heijmans, Hein W. Verspaget, Ashwin A. Dihal, Philip W. Voorneveld, Gijs R. van den Brink, James C. H. Hardwick, Vanesa Muncan, Manon E. Wildenberg, Carina L. Bos, Bart Baan
Publikováno v:
Gut, 61(12), 1708-1715
Baan, B, Dihal, A A, Hoff, E, Bos, C L, Voorneveld, P W, Koelink, P J, Wildenberg, M E, Muncan, V, Heijmans, J, Verspaget, H W, Richel, D J, Hardwick, J C H, Hommes, D W, Peppelenbosch, M P & van den Brink, G R 2012, ' 5-aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer ', Gut, vol. 61, no. 12, pp. 1708-1715 . https://doi.org/10.1136/gutjnl-2011-301626
Gut, 61(12), 1708-1715. BMJ Publishing Group
Baan, B, Dihal, A A, Hoff, E, Bos, C L, Voorneveld, P W, Koelink, P J, Wildenberg, M E, Muncan, V, Heijmans, J, Verspaget, H W, Richel, D J, Hardwick, J C H, Hommes, D W, Peppelenbosch, M P & van den Brink, G R 2012, ' 5-aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer ', Gut, vol. 61, no. 12, pp. 1708-1715 . https://doi.org/10.1136/gutjnl-2011-301626
Gut, 61(12), 1708-1715. BMJ Publishing Group
Background 5-aminosalicylic acid (5-ASA) may protect against the development of inflammation-associated colorectal cancer. In vitro data suggest that, in colorectal cancer cells, 5-ASA induces cell cycle arrest, but the molecular mechanism leading to
Autor:
Daniel W. Hommes, Gijs R. van den Brink, Philip W. Voorneveld, Maikel P. Peppelenbosch, James C. H. Hardwick, Manon E. Wildenberg, Tom van Wezel, Rutger J. Jacobs, Hans Morreau, Liudmila L. Kodach, H. W. Verspaget
Publikováno v:
Gut, 60(11), 1544-1553. BMJ Publishing Group
Gut
Gut, 60(11), 1544-1553
Gut
Gut, 60(11), 1544-1553
Background Promoter hypermethylation is an important and potentially reversible mechanism of tumour suppressor gene silencing in cancer. Compounds that demethylate tumour suppressor genes and induce differentiation of cancer cells, but do not have to
Autor:
Helene Roelofs, Willem E. Fibbe, Barbara B. Wendrich, Daniel W. Hommes, Marjolijn Duijvestein, Frits Koning, Engelina Maria Christina Kooy-Winkelaar, Herma H. Fidder, Manon E. Wildenberg, Jaap Jan Zwaginga, Anne Christine W. Vos, H. W. Verspaget, Auke P. Verhaar, Gijs R. van den Brink
Publikováno v:
Gut
Gut, 59(12), 1662-1669. BMJ Publishing Group
Gut, 59(12), 1662-1669
Gut, 59(12), 1662-1669. BMJ Publishing Group
Gut, 59(12), 1662-1669
Background and aim Mesenchymal stromal cells (MSCs) are pluripotent cells that have immunosuppressive effects both in vitro and in experimental colitis. Promising results of MSC therapy have been obtained in patients with severe graft versus host dis
Publikováno v:
Gut, 65(5), 727-728. BMJ Publishing Group
Over the past decades, incidence rates of immune-mediated inflammatory diseases including asthma and IBDs have been rising steadily in both Western and low/middle-income countries.1 The cause of this increase has been a topic of intense investigation
Autor:
Vanesa Muncan, Nikè V. J. A. Büller, Amy S. Lee, Sanne L. Rosekrans, Jessica Westerlund, Jarom Heijmans, Gijs R. van den Brink
Publikováno v:
Gut, 64(2), 195-202. BMJ Publishing Group
Gut
Gut
Objective Stress in the endoplasmic reticulum (ER) leads to activation of the unfolded protein response (UPR). Xbp1, a key component of the UPR has recently been linked to the risk of developing oesophageal squamous cell carcinoma, suggesting an impo
Autor:
Krisztina B, Gecse, Reena, Khanna, Gijs R, van den Brink, Cyriel Y, Ponsioen, Mark, Löwenberg, Vipul, Jairath, Simon P L, Travis, William J, Sandborn, Brian G, Feagan, Geert R A M, D'Haens
Publikováno v:
Gut. 62(6)
Autor:
Alon D. Levin, Gijs R. van den Brink
Publikováno v:
Gut, 63(6), 866-867. BMJ Publishing Group
Serotonin (5-HT) has extensively been studied in the central and enteric nervous system. Altered levels of 5-HT play a role in many central nervous system (CNS) disorders and can be treated with specific 5-HT receptor agonists and antagonists. Intere
Publikováno v:
Gut, 60(4), 432-433. BMJ Publishing Group
Bile salts are produced in the liver and delivered to the duodenum, where they emulsify lipids to facilitate absorption. After passing through the small intestine, the majority of bile salts are reabsorbed for recycling in the terminal ileum. One of