Zobrazeno 1 - 3
of 3
pro vyhledávání: '"D. Gareth Evans"'
Autor:
Emma R. Woodward, Conxi Lázaro, D. Gareth Evans, Pau M. Munoz-Torres, George J Burghel, Gabriel Capellá, Mariona Terradas, Matilde Navarro, Marta Pineda, Isabel Quintana, Laura Valle, Victor Moreno, Pilar Mur, Sami Belhadj, Joan Brunet
Publikováno v:
Gut. 70:1139-1146
ObjectiveGermline TP53 pathogenic (P) variants cause Li-Fraumeni syndrome (LFS), an aggressive multitumor-predisposing condition. Due to the implementation of multigene panel testing, TP53 variants have been detected in individuals without LFS suspic
Autor:
Finlay A. Macrae, Gabriela Möslein, Jukka-Pekka Mecklin, D. Gareth Evans, Annika Lindblom, John Burn, Matilde Navarro, Fiona Lalloo, Lone Sunde, Paola Sala, Eivind Hovig, Gabriel Capellá, Einar Andreas Rødland, Julian R. Sampson, Lucio Bertario, Ian M. Frayling, Pål Møller, Laura Renkonen-Sinisalo, Kate Green, John-Paul Plazzer, Miriam Mints, Kukatharmini Tharmaratnam, James Hill, Ignacio Blanco, Sigve Nakken, Marta Pineda, Rolf H. Sijmons, Mark A. Jenkins, Maurizio Genuardi, Inge Bernstein, Toni T. Seppälä, Elke Holinski-Feder, Hans F. A. Vasen, Wouter H. de Vos tot Nederveen Cappel, Kirsi Pylvänäinen, Monika Morak, Juul T. Wijnen, Jacqueline Jeffries
Publikováno v:
Gut
Møller, P, Seppälä, T, Bernstein, I, Holinski-Feder, E, Sala, P, Evans, D G, Lindblom, A, Macrae, F, Blanco, I, Sijmons, R, Jeffries, J, Vasen, H, Burn, J, Nakken, S, Hovig, E, Rødland, E A, Tharmaratnam, K, de Vos Tot Nederveen Cappel, W H, Hill, J, Wijnen, J, Jenkins, M, Green, K, Lalloo, F, Sunde, L, Mints, M, Bertario, L, Pineda, M, Navarro, M, Morak, M, Renkonen-Sinisalo, L, Frayling, I M, Plazzer, J-P, Pylvanainen, K, Genuardi, M, Mecklin, J-P, Möslein, G, Sampson, J R, Capella, G & Mallorca Group (http://mallorca-group.org) 2017, ' Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer : a report from the prospective Lynch syndrome database ', Gut, vol. 66, no. 9, pp. 1657-1664 . https://doi.org/10.1136/gutjnl-2016-311403
Gut, 66(9), 1657-1664. BMJ PUBLISHING GROUP
Gut, 66(9), 1657-1664
Møller, P, Seppälä, T, Bernstein, I, Holinski-Feder, E, Sala, P, Evans, D G, Lindblom, A, Macrae, F, Blanco, I, Sijmons, R, Jeffries, J, Vasen, H, Burn, J, Nakken, S, Hovig, E, Rødland, E A, Tharmaratnam, K, de Vos Tot Nederveen Cappel, W H, Hill, J, Wijnen, J, Jenkins, M, Green, K, Lalloo, F, Sunde, L, Mints, M, Bertario, L, Pineda, M, Navarro, M, Morak, M, Renkonen-Sinisalo, L, Frayling, I M, Plazzer, J-P, Pylvanainen, K, Genuardi, M, Mecklin, J-P, Möslein, G, Sampson, J R, Capella, G & Mallorca Group (http://mallorca-group.org) 2016, ' Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database. ', Gut . https://doi.org/10.1136/gutjnl-2016-311403
Dipòsit Digital de la UB
Universidad de Barcelona
Møller, P, Seppälä, T, Bernstein, I, Holinski-Feder, E, Sala, P, Evans, G, Lindblom, A, Macrae, F, Blanco, I, Sijmons, R, Jeffries, J, Vasen, H, Burn, J, Nakken, S, Hovig, E, Rødland, E A, Tharmaratnam, K, de Vos tot Nederveen Cappel, W H, Hill, J, Wijnen, J, Jenkins, M, Green, K, Lalloo, F, Sunde, L, Mints, M, Bertario, L, Pineda, M, Navarro, M, Morak, M, Renkonen-Sinisalo, L, Frayling, I M, Plazzer, J P, Pylvanainen, K, Genuardi, M, Mecklin, J P, Möslein, G, Sampson, J R & Capella, G 2016, ' Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer : a report from the prospective Lynch syndrome database ', Gut . https://doi.org/10.1136/gutjnl-2016-311403
Møller, P, Seppälä, T, Bernstein, I, Holinski-Feder, E, Sala, P, Evans, D G, Lindblom, A, Macrae, F, Blanco, I, Sijmons, R, Jeffries, J, Vasen, H, Burn, J, Nakken, S, Hovig, E, Rødland, E A, Tharmaratnam, K, de Vos Tot Nederveen Cappel, W H, Hill, J, Wijnen, J, Jenkins, M, Green, K, Lalloo, F, Sunde, L, Mints, M, Bertario, L, Pineda, M, Navarro, M, Morak, M, Renkonen-Sinisalo, L, Frayling, I M, Plazzer, J-P, Pylvanainen, K, Genuardi, M, Mecklin, J-P, Möslein, G, Sampson, J R, Capella, G & Mallorca Group (http://mallorca-group.org) 2017, ' Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer : a report from the prospective Lynch syndrome database ', Gut, vol. 66, no. 9, pp. 1657-1664 . https://doi.org/10.1136/gutjnl-2016-311403
Gut, 66(9), 1657-1664. BMJ PUBLISHING GROUP
Gut, 66(9), 1657-1664
Møller, P, Seppälä, T, Bernstein, I, Holinski-Feder, E, Sala, P, Evans, D G, Lindblom, A, Macrae, F, Blanco, I, Sijmons, R, Jeffries, J, Vasen, H, Burn, J, Nakken, S, Hovig, E, Rødland, E A, Tharmaratnam, K, de Vos Tot Nederveen Cappel, W H, Hill, J, Wijnen, J, Jenkins, M, Green, K, Lalloo, F, Sunde, L, Mints, M, Bertario, L, Pineda, M, Navarro, M, Morak, M, Renkonen-Sinisalo, L, Frayling, I M, Plazzer, J-P, Pylvanainen, K, Genuardi, M, Mecklin, J-P, Möslein, G, Sampson, J R, Capella, G & Mallorca Group (http://mallorca-group.org) 2016, ' Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database. ', Gut . https://doi.org/10.1136/gutjnl-2016-311403
Dipòsit Digital de la UB
Universidad de Barcelona
Møller, P, Seppälä, T, Bernstein, I, Holinski-Feder, E, Sala, P, Evans, G, Lindblom, A, Macrae, F, Blanco, I, Sijmons, R, Jeffries, J, Vasen, H, Burn, J, Nakken, S, Hovig, E, Rødland, E A, Tharmaratnam, K, de Vos tot Nederveen Cappel, W H, Hill, J, Wijnen, J, Jenkins, M, Green, K, Lalloo, F, Sunde, L, Mints, M, Bertario, L, Pineda, M, Navarro, M, Morak, M, Renkonen-Sinisalo, L, Frayling, I M, Plazzer, J P, Pylvanainen, K, Genuardi, M, Mecklin, J P, Möslein, G, Sampson, J R & Capella, G 2016, ' Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer : a report from the prospective Lynch syndrome database ', Gut . https://doi.org/10.1136/gutjnl-2016-311403
OBJECTIVE: Today most patients with Lynch syndrome (LS) survive their first cancer. There is limited information on the incidences and outcome of subsequent cancers. The present study addresses three questions: (i) what is the cumulative incidence of
Autor:
Møller P; Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway.; Center for Hereditary Tumors, HELIOS-Klinikum Wuppertal, University of Witten-Herdecke, Wuppertal, Germany., Seppälä TT; Department of Gastrointestinal Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland., Bernstein I; The Danish Hereditary Non-polyposis Colorectal Cancer Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.; Department of Surgical Gastroenterology, Aalborg University Hospital, Aalborg, Denmark., Holinski-Feder E; Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Ziemssenstr, Germany.; MGZ - Medizinisch Genetisches Zentrum, Munich, Germany., Sala P; Unit of Hereditary Digestive Tract Tumors IRCCS Istituto Nazionale Tumori Milan, Milano, Italy., Gareth Evans D; Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, London, UK.; Manchester Centre for Genomic Medicine, University of Manchester, London, UK., Lindblom A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Macrae F; Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melborne, Australia.; Department of Medicine, Melbourne University, Melborne, Australia., Blanco I; Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain., Sijmons RH; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Jeffries J; Division of Cancer and Genetics, Institute of Medical Genetics, Cardiff University School of Medicine, Heath Park, UK., Vasen HFA; Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands., Burn J; Institute of Genetic Medicine Newcastle University, Newcastle upon Tyne, UK., Nakken S; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway., Hovig E; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway.; Institute of Cancer Genetics and Informatics, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway.; Department of Informatics, University of Oslo, Olso, Norway., Rødland EA; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway., Tharmaratnam K; Department of Mathematics and Statistics, Lancaster University, Lancaster, UK., de Vos Tot Nederveen Cappel WH; Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands., Hill J; Department of Surgery, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester, London, UK., Wijnen JT; Department of Clinical Genetics and Department of Human Genetics Leiden, University Medical Centre, Leiden, The Netherlands., Jenkins MA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia., Green K; Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, London, UK.; Manchester Centre for Genomic Medicine, University of Manchester, London, UK., Lalloo F; Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, London, UK.; Manchester Centre for Genomic Medicine, University of Manchester, London, UK., Sunde L; Department of Surgical Gastroenterology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Mints M; Department of Women's and Children's health, Division of Obstetrics and Gyneacology, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden., Bertario L; Unit of Hereditary Digestive Tract Tumors IRCCS Istituto Nazionale Tumori Milan, Milano, Italy., Pineda M; Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain., Navarro M; Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain., Morak M; Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Ziemssenstr, Germany.; MGZ - Medizinisch Genetisches Zentrum, Munich, Germany., Renkonen-Sinisalo L; Department of Gastrointestinal Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Valentin MD; Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway., Frayling IM, Plazzer JP; Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melborne, Australia., Pylvanainen K; Department of Education and Science, Central Finland Health Care District, yväskylä, Finland., Genuardi M; Institute of Genomic Medicine, 'A. Gemelli' Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy., Mecklin JP; University of Eastern Finland, Kuopio, Finland., Moeslein G, Sampson JR; Division of Cancer and Genetics, Institute of Medical Genetics, Cardiff University School of Medicine, Heath Park, UK., Capella G; Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; Center for Hereditary Tumors, HELIOS-Klinikum Wuppertal, University of Witten-Herdecke, Wuppertal, Germany.
Publikováno v:
Gut [Gut] 2018 Jul; Vol. 67 (7), pp. 1306-1316. Date of Electronic Publication: 2017 Jul 28.