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Autor:
José L. M. Madrigal, Juan C. Leza, Marta González-Prieto, Adriana Ortega-Hernández, Borja García-Bueno, Irene L Gutiérrez, Dulcenombre Gómez-Garre, Javier R. Caso
Publikováno v:
Glia. 69:73-90
The loss of noradrenergic neurons and subsequent reduction of brain noradrenaline (NA) levels are associated with the progression of Alzheimer's disease (AD). This seems to be due mainly to the ability of NA to reduce the activation of microglial cel
Publikováno v:
Glia. 56:233-240
Damage to oligodendrocytes caused by glutamate release contributes to mental or physical handicap in periventricular leukomalacia, spinal cord injury, multiple sclerosis, and stroke, and has been attributed to activation of AMPA/kainate receptors. Ho
Publikováno v:
Glia. 55:263-273
Transferrin receptors (Tfrc) are membrane bound glycoproteins which function to mediate cellular uptake of iron from transferrin. We examined expression of Tfrc in the pineal gland of rats of different ages from 1 day to 12 weeks. The mRNA and protei
Autor:
Mami Noda, Masayuki Sekiguchi, Yukihiro Kariura, Bing Wang, Yukiko Hagino, Yoshimasa Manago, Keiji Wada, Shunsuke Aoki, Taiju Amano, Kaori Nishikawa
Publikováno v:
Glia. 47:68-77
alpha-amino-hydroxy-5-methyl-isoxazole-4-propionate (AMPA) receptor in rat cultured microglia were analyzed precisely using flop- and flip-preferring allosteric modulators of AMPA receptors, 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyac
Autor:
Kazuhide Inoue, Jun-ichi Sawada, Seiichi Ishida, Yasuo Ohno, Youichi Shinozaki, Schuichi Koizumi
Publikováno v:
Glia. 49:288-300
Oxidative stress is the main cause of neuronal damage in traumatic brain injury, hypoxia/reperfusion injury, and neurodegenerative disorders. Although extracellular nucleosides, especially adenosine, are well known to protect against neuronal damage
Publikováno v:
Glia. 44:166-172
A1 adenosine receptors (A1ARs) exert important effects in the central nervous system. However, the expression and function of A1ARs in oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLGs) is unclear. To address this issue, we examined A
Publikováno v:
Glia. 41:161-168
Upon activation, brain microglial cells release proinflammatory mediators, such as TNFalpha, which may play an important role in eliciting neuroinflammatory processes causing brain damage. As cannabinoids have been reported to exert anti-inflammatory
Publikováno v:
Glia. 37:53-63
Protease-activated receptors (PARs) are newly identified members of the superfamily of G-protein-coupled receptors that initiate cell signaling by the proteolytic activity of extracellular serine proteases. Certain proteases are believed to be involv
Autor:
Julie A. McLachlan, Zvi Vogel, Robert J. McHale, Jacob Barg, Mariana M. Belcheva, Frank E. Johnson, Rivka Levy, Carmine J. Coscia
Publikováno v:
Glia. 10:10-15
Treatment of rat C6 glioma cells with the tricyclic antidepressant desipramine induces opioid binding. Here the distribution of these opioid-binding sites on C6 cell membranes and a functional property were investigated. Immunohistochemical examinati
Autor:
Thomas Fahrig
Publikováno v:
Glia. 7:212-218
Glutamate uptake into rat brain astrocytes is potently stimulated by addition of norepinephrine (NE). This effect is mediated by α1-adrenergic receptors expressed by these cells (Hansson and Ronnback: Life Sci 44:27, 1989; Brain Res 548:215, 1991).