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Autor:
Suzan Sweitat, Yulia Mitiagin, Ronit Galron, Ela Bar, Stav Cohen-Adiv, Sivan Kanner, Ari Barzilai, Hadar Levi
Publikováno v:
Glia. 70:536-557
Ataxia-telangiectasia (A-T) is a multisystem autosomal recessive disease caused by mutations in the ATM gene and characterized by cerebellar atrophy, progressive ataxia, immunodeficiency, male and female sterility, radiosensitivity, cancer predisposi
Publikováno v:
Glia. 70:808-819
Since the early observations made by Santiago Ramon y Cajal more than a century ago till now, astrocytes have gradually gained protagonism as essential partners of neurons in building brain circuits that regulate complex behavior. In mammals, process
Autor:
Monika Madej, Jenny Lange, Simon Eaton, Patrizia Ferretti, Michael Flower, Olivia Gillham, Francesco Muntoni, Francesco Tedesco, Reem Alkharji, Giulia Ferrari
Publikováno v:
Glia. 70:466-490
In addition to progressive muscular degeneration due to dystrophin mutations, 1/3 of Duchenne muscular dystrophy (DMD) patients present cognitive deficits. However, there is currently an incomplete understanding about the function of the multiple dys
Autor:
Claire Wyart, Adeline Orts-Del’Immagine, Mahalakshmi Dhanasekar, Julian Roussel, François-Xavier Lejeune
Publikováno v:
Glia. 70:491-507
Although calcium waves have been widely observed in glial cells, their occurrence in vivo during behavior remains less understood. Here, we investigated the recruitment of glial cells in the hindbrain and spinal cord after acousto-vestibular (AV) sti
Autor:
Minkyung Kang, Yao Yao
Publikováno v:
Glia
Oligodendrocytes are the cells that myelinate axons and provide trophic support to neurons in the CNS. Their dysfunction has been associated with a group of disorders known as demyelinating diseases, such as multiple sclerosis. Oligodendrocytes are d
Publikováno v:
Glia
The brain requires an adequate supply of oxygen and nutrients to maintain proper function as neuronal activity varies. This is achieved, in part, through neurovascular coupling mechanisms that mediate local increases in blood flow through the dilatio
Publikováno v:
Glia
Glia, vol 70, iss 3
Glia, vol 70, iss 3
The classical complement cascade mediates synapse elimination in the visual thalamus during early brain development. However, whether the primary visual cortex also undergoes complement-mediated synapse elimination during early visual system developm
Autor:
Yu Zhenwei, Zongran Liu, Xiaodan Liu, Zhang Jing, Robin Barry Chan, Pan Wang, Lan Guoyu, Ying Yang
Publikováno v:
Glia. 70:337-353
The integrity of blood-brain-barrier (BBB) is essential for normal brain functions, synaptic remodeling, and angiogenesis. BBB disruption is a common pathology during Parkinson's disease (PD), and has been hypothesized to contribute to the progressio
Autor:
Veronique E. Miron, Lindsey H. Forbes
Publikováno v:
Glia. 70:797-807
Remyelination failure with aging and progression of neurodegenerative disorders contributes to axonal dysfunction, highlighting the importance of understanding the mechanisms underpinning this process to develop regenerative therapies. Central nervou
Autor:
Neelakshi Soni, Kim N. Green, Miguel A. Arreola, Caden M Henningfield, Elizabeth E. Spangenberg
Publikováno v:
Glia
Previous studies suggest that microglial-expressed Apolipoprotein E (ApoE) is necessary to shift microglia into a neurodegenerative transcriptional state in Alzheimer's disease (AD) mouse models. On the other hand, elimination of microglia shifts amy