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Autor:
Suzan Sweitat, Yulia Mitiagin, Ronit Galron, Ela Bar, Stav Cohen-Adiv, Sivan Kanner, Ari Barzilai, Hadar Levi
Publikováno v:
Glia. 70:536-557
Ataxia-telangiectasia (A-T) is a multisystem autosomal recessive disease caused by mutations in the ATM gene and characterized by cerebellar atrophy, progressive ataxia, immunodeficiency, male and female sterility, radiosensitivity, cancer predisposi
Autor:
Claire Wyart, Adeline Orts-Del’Immagine, Mahalakshmi Dhanasekar, Julian Roussel, François-Xavier Lejeune
Publikováno v:
Glia. 70:491-507
Although calcium waves have been widely observed in glial cells, their occurrence in vivo during behavior remains less understood. Here, we investigated the recruitment of glial cells in the hindbrain and spinal cord after acousto-vestibular (AV) sti
Autor:
Yu Zhenwei, Zongran Liu, Xiaodan Liu, Zhang Jing, Robin Barry Chan, Pan Wang, Lan Guoyu, Ying Yang
Publikováno v:
Glia. 70:337-353
The integrity of blood-brain-barrier (BBB) is essential for normal brain functions, synaptic remodeling, and angiogenesis. BBB disruption is a common pathology during Parkinson's disease (PD), and has been hypothesized to contribute to the progressio
Autor:
Julia E. Manoim, Moshe Parnas, Lauren C. Clamon, Kiel G. Ormerod, J. Troy Littleton, Shirley Weiss
Publikováno v:
Glia. 70:123-144
Astrocytes play key roles in regulating multiple aspects of neuronal function from invertebrates to humans and display Ca2+ fluctuations that are heterogeneously distributed throughout different cellular microdomains. Changes in Ca2+ dynamics represe
Autor:
Masayoshi Tanaka, Junichi Nabekura, Yuri Hirayama, Kozo Saito, Eiji Shigetomi, Yosuke Danjo, Sun Kwang Kim, Yuto Kubota, Bijay Parajuli, Ji Hwan Lee, Youichi Shinozaki, Hiroaki Nagatomo, Schuichi Koizumi
Publikováno v:
Glia. 69:2546-2558
Metabotropic glutamate receptor 5 (mGluR5) in astrocytes is a key molecule for controlling synapse remodeling. Although mGluR5 is abundant in neonatal astrocytes, its level is gradually down-regulated during development and is almost absent in the ad
Autor:
Farina Windener, Alexander Zarbock, Laureen Grewing, Julia Ghelman, Stefanie Albrecht, Tanja Kuhlmann
Publikováno v:
Glia. 69:2699-2716
Oligodendroglial progenitor cells (OPC) are highly proliferative and migratory bipolar cells, which differentiate into complex myelin forming and axon ensheathing mature oligodendrocytes during myelination. Recent studies indicate that the oligodendr
Autor:
Hiroto Miwa, Shigeki Omachi, Koji Takahashi, Kinichi Nakashima, Sosuke Yoneda, Bijay Parajuli, Miki Tanimura, Masahide Fujita, Hiroki Saito, Toshiyuki Asaki, Eiji Shigetomi, Schuichi Koizumi, Youichi Shinozaki
Publikováno v:
Glia. 69:2332-2348
Microglia are the resident immune cells of the brain, and play essential roles in neuronal development, homeostatic function, and neurodegenerative disease. Human microglia are relatively different from mouse microglia. However, most research on huma
Publikováno v:
Glia. 69:2429-2446
Multiple signals are involved in the regulation of developmental myelination by Schwann cells and in the maintenance of a normal myelin homeostasis throughout adult life, preserving the integrity of the axons in the PNS. Recent studies suggest that M
Autor:
Yanping Chen, Jiancheng Wu, Xiaosong Gu, Yaxian Wang, Yan Lu, Bin Yu, Xin-Peng Dun, Qihui Wang, Xuemin Cao, Wei Feng, Chun Yao
Publikováno v:
Glia. 69:2391-2403
Peripheral nerve injury triggers sequential phenotype alterations in Schwann cells, which are critical for axonal regeneration. Long noncoding RNAs (lncRNAs) are long transcripts without obvious coding potential. It has been reported that lncRNAs par
Publikováno v:
Glia
Despite combined antiretroviral therapy (cART), HIV-associated neurocognitive disorder (HAND) affects 30-50% of HIV-positive patients. Importantly, persistent white matter pathologies, specifically corpus callosum thinning and disruption of white mat