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Publikováno v:
Glia
Despite combined antiretroviral therapy (cART), HIV-associated neurocognitive disorder (HAND) affects 30-50% of HIV-positive patients. Importantly, persistent white matter pathologies, specifically corpus callosum thinning and disruption of white mat
Autor:
Mriganka Sur, Rodrigo Garófallo Garcia, Jeremy Petravicz, Rajeev V. Rikhye, Nikolaos Mellios, Grayson O. Sipe
Publikováno v:
Glia
The uptake of glutamate by astrocytes actively shapes synaptic transmission, however its role in the development and plasticity of neuronal circuits remains poorly understood. The astrocytic glutamate transporter, GLT1 is the predominant source of gl
Autor:
Weinan Sun, Yukiko Itou, Kaori Sugiyama, Haruhi Terai, Kohichi Tanaka, Saori Toyoda, Hidenori Aizawa, Michiko Yanagisawa, Wanpeng Cui, Tomomi Aida
Publikováno v:
Glia. 68:2631-2642
Cortical spreading depression (CSD) is a pathological neural excitation that underlies migraine pathophysiology. Since glutamate receptor antagonists impair CSD propagation, susceptibility to CSD might be determined by any of the neuronal (excitatory
Autor:
María Victoria Sánchez-Gómez, Tania Quintela-López, Elena Alberdi, Asier Ruiz, Adhara Gaminde-Blasco, Carlos Matute
Publikováno v:
Glia. 68:1743-1756
Mitochondrial fission mediated by cytosolic dynamin related protein 1 (Drp1) is essential for mitochondrial quality control but may contribute to apoptosis as well. Blockade of Drp1 with mitochondrial division inhibitor 1 (mdivi-1) provides neuroprot
Publikováno v:
Glia
Disruption of the circadian cycle is strongly associated with metabolic imbalance and reduced longevity in humans. Also, rodent models of circadian arrhythmia, such as the constitutive knockout of the clock gene Bmal1, leads to metabolic disturbances
Autor:
Oliver Kann, Anne Albrecht, Uwe Heinemann, Sebastian Ivens, Ansgar Malich, Oliver Stork, Gürsel Çalışkan, Tiziana Cesetti, Ismini Papageorgiou
Publikováno v:
Glia. 67:2279-2293
A traumatic childhood is among the most important risk factors for developing stress-related psychopathologies such as posttraumatic stress disorder or depression later in life. However, despite the proven role of astrocytes in regulating transmitter
Publikováno v:
Glia. 67:2071-2091
Fast chemical synaptic transmission is a major form of neuronal communication in the nervous system of mammals. Another important, but very different, form of intercellular communication is volume transmission, which is a slower non-synaptic signalin
Publikováno v:
Glia
Glia, Wiley, 2019, 67 (6), pp.1104-1112. ⟨10.1002/glia.23591⟩
Glia, Wiley, 2019, 67 (6), pp.1104-1112. ⟨10.1002/glia.23591⟩
Astroglial networks mediated by gap junction channels contribute to neurotransmission and promote neuronal coordination. Connexin 30, one of the two main astroglial gap junction forming protein, alters at the behavioral level the reactivity of mice t
Publikováno v:
Glia. 66:2299-2315
Neuroprotective effects of erythropoietin (EPO) on peripheral nerve injury remain uncertain. This study investigated the efficacy of EPO in attenuating median nerve chronic constriction injury (CCI)-induced neuropathy. Animals received an intraneural
Publikováno v:
Glia. 66:2604-2616
Astrocytes form the largest class of glial cells in the central nervous system. They serve plenty of diverse functions that range from supporting the formation and proper operation of synapses to controlling the blood-brain barrier. For many of them,