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Autor:
Monika Madej, Jenny Lange, Simon Eaton, Patrizia Ferretti, Michael Flower, Olivia Gillham, Francesco Muntoni, Francesco Tedesco, Reem Alkharji, Giulia Ferrari
Publikováno v:
Glia. 70:466-490
In addition to progressive muscular degeneration due to dystrophin mutations, 1/3 of Duchenne muscular dystrophy (DMD) patients present cognitive deficits. However, there is currently an incomplete understanding about the function of the multiple dys
Publikováno v:
Glia. 69:2429-2446
Multiple signals are involved in the regulation of developmental myelination by Schwann cells and in the maintenance of a normal myelin homeostasis throughout adult life, preserving the integrity of the axons in the PNS. Recent studies suggest that M
Autor:
Yanping Chen, Jiancheng Wu, Xiaosong Gu, Yaxian Wang, Yan Lu, Bin Yu, Xin-Peng Dun, Qihui Wang, Xuemin Cao, Wei Feng, Chun Yao
Publikováno v:
Glia. 69:2391-2403
Peripheral nerve injury triggers sequential phenotype alterations in Schwann cells, which are critical for axonal regeneration. Long noncoding RNAs (lncRNAs) are long transcripts without obvious coding potential. It has been reported that lncRNAs par
Publikováno v:
Glia
Despite combined antiretroviral therapy (cART), HIV-associated neurocognitive disorder (HAND) affects 30-50% of HIV-positive patients. Importantly, persistent white matter pathologies, specifically corpus callosum thinning and disruption of white mat
Autor:
Robin R. Ali, Anna B. Graca, James W B Bainbridge, Alexander J. Smith, Ayako Matsuyama, Joana Ribeiro, Rachael A. Pearson, Mark Basche, Nozie D. Aghaizu, Aikaterini A Kalargyrou, Anastasios Georgiadis, Claire Hippert
Publikováno v:
Glia. 69:2272-2290
Gliosis is a complex process comprising upregulation of intermediate filament (IF) proteins, particularly glial fibrillary acidic protein (GFAP) and vimentin, changes in glial cell morphology (hypertrophy) and increased deposition of inhibitory extra
Autor:
Thomas J. Anderson, Alain Kohl, Susan C. Barnett, Claire L. Donald, Tom Solomon, Hugh J. Willison, Verena Schultz, Christopher Linington, Margaret Mullin, Julia M. Edgar, Colin L. Crawford, Jennifer A. Barrie
Publikováno v:
Glia. 69:2023-2036
Some children with proven intrauterine Zika virus (ZIKV) infection who were born asymptomatic subsequently manifested neurodevelopmental delays, pointing to impairment of development perinatally and postnatally. To model this, we infected postnatal d
Autor:
Tomomi Furihata, Wenqiang Quan, Wenlin Hao, Inge Tomic, Walter Schulz-Schäffer, Yang Liu, Klaus Fassbender, Michael D. Menger, Qinghua Luo
Publikováno v:
Glia. 69:1987-2005
Growing evidence indicates that innate immune molecules regulate microglial activation in Alzheimer's disease (AD); however, their effects on amyloid pathology and neurodegeneration remain inconclusive. Here, we conditionally deleted one allele of my
Autor:
Narayan Dhimal, Jacob Favret, Daesung Shin, M. Laura Feltri, Nadav I. Weinstock, Lawrence Wrabetz
Publikováno v:
Glia
Globoid cell leukodystrophy (GLD), also known as Krabbe disease, is a lysosomal storage disorder causing extensive demyelination in the central and peripheral nervous systems. GLD is caused by loss-of-function mutations in the lysosomal hydrolase, ga
Autor:
Christopher I. Richards, Jourdan E Lakes, Martha E. Grady, Joree N. Sandin, Xu Fu, Khaga R Neupane, Surya P. Aryal
Publikováno v:
Glia
Nicotine is a highly addictive compound present in tobacco, which causes the release of dopamine in different regions of the brain. Recent studies have shown that astrocytes express nicotinic acetylcholine receptors (nAChRs) and mediate calcium signa
Autor:
Ling Zhu, Rui Zhang, Weiyong Shen, Victoria Pye, Yoshio Hirabayashi, Pankaj Seth, Ashish Easow Mathai, Michelle Yam, Shigeki Furuya, So Ra Lee, James B. Hurley, Jianhai Du, Mark C Gillies, Cassie L. Rayner, Nigel L. Barnett
Publikováno v:
Glia. 69:1966-1986
The importance of Müller glia for retinal homeostasis suggests that they may have vulnerabilities that lead to retinal disease. Here, we studied the effect of selectively knocking down key metabolic genes in Müller glia on photoreceptor health. Imm