Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Donald W. Bowden"'
Autor:
Jennifer B. Ellington, Carl D. Langefeld, Jasmin Divers, Joshua P. Lewis, Maggie C.Y. Ng, Barry I. Freedman, Lingyi Lu, Nicholette D. Palmer, Donald W. Bowden
Publikováno v:
Genomics. 96(4):211-219
Chromosome 20q12-q13.1 has been linked to type 2 diabetes (T2D) in multiple populations. We examined the influence of genes in this region on T2D and BMI in two European American case-control populations. SNPs were genotyped in 300 diabetic patients
Autor:
Carl D. Langefeld, Deborah S. Kiger, Dax C. Allred, Carla J. Colicigno, Donald W. Bowden, Barry I. Freedman, Gregory A. Hawkins, Josyf C. Mychaleckyj, Linda E. Green, Jeannette T. Bensen, Scott Binford, Catherine S. Brewer
Publikováno v:
Genomics. 82:194-217
A dense gene-based SNP map was constructed across a 360-kb region containing the interleukin-1 gene cluster (IL1A, IL1B, and IL1RN), focusing on IL1RN. In total, 95 polymorphisms were confirmed or identified primarily by direct sequencing. Polymorphi
Publikováno v:
Genomics. 69:225-234
Kallikreins are serine proteases that catalyze the release of kinins and other vasoactive peptides. Previously, we have studied one tissue-specific (H. Yu et al., 1996, J. Am. Soc. Nephrol. 7: 2559-2564) and one plasma-specific (H. Yu et al., 1998, H
Publikováno v:
Genomics. 34:122-127
Phosphofructokinase (PFK) is a key rate-limiting enzyme in glycolysis and represents a major control point in the metabolism of glucose. There are at least three known isoforms of PFK in humans, referred to as the muscle, platelet, and liver forms, e
Autor:
Tim Keith, Karen Braunschweiger, Mei-Tai Wang, Nancy Shui-Fong Ma, Jen-I Mao, Melissa K. Schuster, Donald T. Moir, Donald W. Bowden, Cynthia B. Rothschild, Dana Torrey, Thomas E. Dorman, Chuang-jie Zheng, Lorena Soares
Publikováno v:
Genomics. 22:55-67
A total of 124 new chromosome 10-specific sequenced-tagged sites (STSs) were derived from two sources: (1) DNA sequences obtained from anonymous clones in new libraries enriched for human chromosome 10 inserts, and (2) published sequences of genes an
Autor:
Hetal Pandya, Maria R. Wing, Carl D. Langefeld, Donald W. Bowden, Josyf C. Mychaleckyj, B. I. Freedman, Joshua P. Lewis, Nicholette D. Palmer, Bong H. Roh, M. Zhong, Jennifer L. Bento, Stephen S. Rich
Publikováno v:
Genomics. 92(4)
Human chromosome 20q12-13.1 has been linked to type 2 diabetes mellitus (T2DM) in multiple studies. We screened a 5.795Mb region for diabetes-related susceptibility genes in a Caucasian cohort of 310 controls and 300 cases with T2DM and end stage ren
Autor:
Sallyanne C. Fossey, Stephen S. Rich, Donald W. Bowden, Jonathon R Snyder, Shohei Hirakawa, Josyf C. Mychaleckyj, Jeannette T. Bensen, Joanne K. Pendleton, Barry I. Freedman
Publikováno v:
Genomics. 76(1-3)
Recent linkage studies and association analyses indicate the presence of at least one type 2 diabetes susceptibility gene in human chromosome region 20q12-q13.1. We have constructed a high-resolution 6.0-megabase (Mb) transcript map of this interval
Autor:
P. Nagesh Rao, Richard A. Anderson, Caroline Hayward, Donald W. Bowden, Deborah J. Morris, Beverly J. Spray, Bong H. Roh, Mark J. Pettenati, Stefan S. Fajans, Gita Akots, André Reis, Stephen S. Rich, Eleanor Colle, Rosa Hodge, Asif Qadri, Cynthia B. Rothschild, David Brock, Barry I. Freedman, Anton Usala
Publikováno v:
Genomics. 29(1)
PCR primers specific to the human liver fructose-1,6-bisphosphatase (FBP) gene were designed and used to isolate a cosmid clone. Physical mapping of the FBP cosmid by FISH, and genetic mapping of an associated GA repeat polymorphism (PIC = 0.35), loc
Autor:
P. N. Rao, Timothy D. Howard, Mark J. Pettenati, M.D. Krawchuk, Donald W. Bowden, Rosa Hayworth, E.J. Weaver, Cynthia B. Rothschild, Robert G. Knowlton, B. J. Wagner
Publikováno v:
Genomics. 25(2)
The genomic structure of the D20S16 locus has been evaluated using genetic and physical methods. D20S16, originally detected with the probe CRI-L1214, is a highly informative, complex restriction fragment length polymorphism consisting of two separat
Autor:
Nagesh Rao, Richard A. Anderson, Rosa Hayworth, Donald W. Bowden, Robert S. Byrum, Mark J. Pettenati, Cynthia B. Rothschild
Publikováno v:
Genomics. 15(1)
Human acid lipase/cholesteryl esterase (EC 3.1.1.13) is a 46-kDa glycoprotein required for the lysosomal hydrolysis of cholesteryl esters and triglycerides that cells acquire through the receptor-mediated endocytosis of low-density lipoproteins. This