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Publikováno v:
Gene therapy
L-Dopa-induced dyskinesia (LID) is associated with the upregulation of striatal ∆FosB in animal models and patients with Parkinson's disease (PD). A mechanistic role of ∆FosB is suspected because its transgenic overexpression leads to the early a
Autor:
Dan Mu, Hongqiao Zhu, Ying Zhang, Lingfeng He, Zhigang Hu, Longwei Jiang, Yongjing Yang, Congye Wu, Shaochang Jia, Lili Gu, Ting Wu, Zhigang Guo, Jing Zhang, Feiyan Pan, Yuling Sun, Miaomiao Zhang
Publikováno v:
Gene Therapy. 29:407-417
Camptothecin has been used in tumor therapy for a long time but its antitumor effect is rather limited due to the side effect and the drug resistance. FEN1, a major component of DNA repair systems, plays important roles in maintaining genomic stabili
Autor:
Chan Kim, Kyoung-Ju Kim, Youngeun Yoo, Yu Seong Lee, Dahye Moon, Kyung-Ju Choi, So Jung Kong, Joo Hang Kim, So Young Kim, Hong Jae Chon
Publikováno v:
Gene Therapy. 28:186-198
Oncolytic viruses selectively replicate and destroy cancer cells while sparing normal cells, prompting their recognition as promising antitumor agents. Herpes simplex virus (HSV) is suitable as an anticancer agent, given its considerable therapeutic
Publikováno v:
Gene Therapy, 28, 89-104. SPRINGERNATURE
Gene Therapy
Gene Therapy
Lentiviral vectors have become popular tools for stable genetic modification of mammalian cells. In some applications of lentiviral vector-transduced cells, infectious-lentiviral particles should be absent. Quantification of the free-vector particles
Autor:
Wenying Sun, Zhenqiu Gao, Rui Sun, Tianyan Liu, Deshan Li, Shan Jiang, Qingzhong Yu, Zhenzhong Wang, Yu Zhang, Guangchao Sui, Wei Xiao, Jiechao Yin, Xu Sun, Yukai Cao, Guiping Ren
Publikováno v:
Gene Therapy
The direct oncolytic effect of Newcastle disease virus (NDV) depends on the following two aspects: the susceptibility of cancer cells to virus infection and the ability of virus itself to lyse cancer cells. First, we investigate the susceptibility of
Autor:
Chiara Fondello, María Florencia Arbe, Lucrecia Agnetti, Liliana M.E. Finocchiaro, Gerardo Claudio Glikin
Publikováno v:
Gene Therapy. 28:38-55
In the context of comparative oncology, melanoma cells derived from companion animal tumors are good models for optimizing and predicting their in vivo response to therapeutic strategies. Here, we report that human, canine, and feline melanoma cells
Publikováno v:
Gene Therapy.
Immune responses to Cas proteins have been demonstrated recently and these may prove to be an impediment to their clinical use in gene editing. To make meaningful assessments of Cas9 immunogenicity during drug development and licensure it is imperati
Autor:
Elena K Schneider-Futschik
Publikováno v:
Gene Therapy. 26:354-362
Cystic fibrosis (CF) is a life-limiting disease caused by defective or deficient cystic fibrosis transmembrane conductance regulator (CFTR) activity. The recent advent of the FDA-approved CFTR modulator drug ivacaftor, alone or in combination with lu
Publikováno v:
Gene Therapy. 26:418-431
After 6 years of follow-up treating 364 canine melanoma patients, we present here results about the proof-of-concept, safety, and efficacy of a new surgery adjuvant combined gene therapy. The adjuvant treatment (AT) group was divided in three arms as
Publikováno v:
Gene Therapy. 26:75-85
Gene silencing for plasmid-based vectors and the underlying mechanism are critical factors for development of effective gene therapy. The objective of this study is to explore the role of epigenetic regulation for transgene expression. Two reporter g