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Autor:
Kiran Kumar Kolathur
Publikováno v:
Kiran Kumar Kolathur
Alternative splicing (AS) plays a critical role in enhancing proteome complexity in higher eukaryotes. Almost all the multi intron-containing genes undergo AS in humans. Splicing mainly occurs co-transcriptionally, where RNA polymerase II (RNA pol II
Publikováno v:
Gene. 641:117-128
EAF (ELL Associated Factor) proteins interact with the transcription elongation factor, ELL (Eleven nineteen Lysine rich Leukemia) and enhance its ability to stimulate RNA polymerase II-mediated transcriptional elongation in vitro. Schizosaccharomyce
Publikováno v:
Gene. 636:1-16
Epigenetic modifications regulate plant genes to cope with a variety of environmental stresses. Chorispora bungeana is an alpine subnival plant with strong tolerance to multiple abiotic stresses, especially cold stress. In this study, we characterize
Publikováno v:
Gene. 612:19-24
TRIT1 is a highly conserved tRNA isopentenyl transferase that modifies a subset of tRNAs in human cells and is a candidate tumor suppressor in lung cancer in certain ethnic populations. The yeast homologue, Mod5, has similar tRNA-modifying functions
Publikováno v:
Gene. 612:49-54
Circularized oligonucleotides, or coligos, were previously found to serve as RNA polymerase III (Pol III) templates in vitro and in human tissue culture cells. Here we randomized the 12-nucleotide larger loop (L-loop) of a well characterized coligo a
Autor:
David Donze, Qing Wang
Publikováno v:
Gene. 594:108-116
Eukaryotic promoters generally contain nucleosome depleted regions near their transcription start sites. In the model organism Saccharomyces cerevisiae, these regions are adjacent to binding sites for general regulatory transcription factors, and the
Publikováno v:
Gene. 556:19-26
Eukaryotic cells express at least three unique nuclear RNA polymerases. The selective advantage provided by this enhanced complexity is a topic of fundamental interest in cell biology. It has long been known that the gene targets and transcription in
Publikováno v:
Gene. 556:13-18
Mod5 is the yeast tRNA isopentenyl transferase, an enzyme that is conserved from bacteria to humans. Mod5 is primarily cytoplasmic where it modifies the A37 position of a few tRNAs, and the yeast enzyme has been shown capable of forming heritable, am
Autor:
Jian Kang, Ross D. Hannan, Eric P Kusnadi, Rodney J. Hicks, Katherine M. Hannan, Richard B. Pearson
Publikováno v:
Gene. 556:27-34
Exquisite control of ribosome biogenesis is fundamental for the maintenance of cellular growth and proliferation. Importantly, synthesis of ribosomal RNA by RNA polymerase I is a key regulatory step in ribosome biogenesis and a major biosynthetic and
Autor:
Ling Chen, Lei Yang, Lijun Zhu, Chunmei Shi, Guixian Song, Chenbo Ji, Xirong Guo, Guangfeng Xu, Yaping Zhao, Yahui Shen
Publikováno v:
Gene. 533:481-487
Recent findings indicate that microRNAs (miRNAs) are involved in the regulatory network of adipogenesis and obesity. Thus far, only a few human miRNAs are known to function as adipogenic regulators, fanning interest in studies on the functional role