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Autor:
Ahmet Arslan, Mehmet Emin Kalender, Ersin Borazan, Mehri Igci, Ibrahim Bozgeyik, Celaletdin Camci, Recep Bayraktar, Esra Bozgeyik
Publikováno v:
Gene. 586:123-128
Mammalian Sirtuins have been shown to perform distinct cellular functions and deregulated expression of these genes was reported to be involved in the development of various malignancies including breast cancer. An increasing number of evidence indic
Autor:
Samira Shakerizadeh, Asghar Hosseinzadeh, Ahmad Poursadegh Zonouzi, Abolfazl Movafagh, Hedieh Fardmanesh, Ali Akbar Poursadegh Zonouzi, Mohammad Shekari, Shohreh Alizadeh Shargh
Publikováno v:
Gene. 581:146-151
High-throughput experimental studies have indicated that the miRNAome is globally downregulated in various types of malignancy, and dysregulation of miRNAs processing component(s) is one possible mechanism for this phenomenon. Despite the progression
Publikováno v:
Gene. 675
Breast cancer (BC) is one of the most common malignancies in female worldwide. Long non-coding RNAs (lncRNAs) play imperative roles in cancer cell initiation and progression. Recently, aberrantly expressed LINC01296 was observed in several malignanci
Autor:
Hye Ok Kim, Juhie Lee, Hyung Hwan Baik, Sang Sook Lee, Won Jae Choe, Kyung-Sik Yoon, Chang Hoon Cho, Yong Hwa Jo, In Sug Kang
Publikováno v:
Gene. 517:184-190
Microcephalin 1 (MCPH1) has a crucial role in the DNA damage response by promoting the expression of checkpoint kinase 1 (CHK1) and breast cancer susceptibility gene 1 (BRCA1). MCPH1 containing BRCT domain has been suggested as a tumor suppressor in
Autor:
Dan Chen, Li Ding, Jia-ji Ding, Jianzhong Wu, Rong Ma, Long-ji Luo, Dan-Dan Wang, Jian Li, Da-li Yan, Jinhai Tang, Fan Yang, Sujin Yang
Publikováno v:
Gene. 594(1)
Metastasis is the leading cause of death among breast cancer (BCa) patients and triple negative breast cancer (TNBC) as one of BCa subtypes exhibits the worst survival rate due to its highly aggressive and metastatic behavior. A growing body of resea
Autor:
Ismet Tasdelen, Gulsah Cecener, Sahsine Tolunay, Unal Egeli, Berrin Tunca, Sehsuvar Gokgoz, Secil Ak, Elif Demirdogen Sevinc
Publikováno v:
Gene. 590(2)
The dysregulation of miRNA expression has frequently been observed in breast cancer. Therefore, we investigated the expression profile of miRNAs that may be associated with expression of the FHIT gene in breast cancer and assessed their clinicopathol
Autor:
Salman A. H. Alrokayan, M. Janaki Ramaiah, Shaik Mohammad Naushad, Raghunadharao Digumarti, Manickam Pavithrakumari, Vijay Kumar Kutala, Tajamul Hussain, Jaganathan Jayapriya, Suryanarayana Raju Gottumukkala
Publikováno v:
Gene. 580(2)
In the current study, an artificial neural network (ANN)-based breast cancer prediction model was developed from the data of folate and xenobiotic pathway genetic polymorphisms along with the nutritional and demographic variables to investigate how m
Publikováno v:
Gene. 568(2)
Germ-line mutation in CDH1 gene is associated with high risk for Hereditary Diffuse Gastric Cancer (HDGC) and Infiltrative Lobular Carcinoma (ILC). Although somatic CDH1 mutations were also detected in ILC with a frequency ranging from 10 to 56%, CDH
Association of glutamate carboxypeptidase II (GCPII) haplotypes with breast and prostate cancer risk
Autor:
Ch. Ram Reddy, Anthony Addlagatta, Shaik Mohammad Naushad, Shree Divyya, Raghunadharao Digumarti, Sreedhar Amere Subbarao, Vijay Kumar Kutala, Suryanarayana Raju Gottumukkala, P.V.L.N. Murthy
Publikováno v:
Gene. 516(1)
In view of the pivotal role of glutamate carboxypeptidase II (GCPII) in carcinogenesis, its expression as prostate specific membrane antigen (PSMA) and folate hydrolase (FOLH1) may be influenced by its haplotypes, contributing to the etiology of pros