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Autor:
Zsanett Jancsó, Miklós Sahin-Tóth
Publikováno v:
Gastroenterology
Background & Aims Mutations in the human serine protease 1 gene (PRSS1), which encodes cationic trypsinogen, can accelerate its autoactivation and cause hereditary or sporadic chronic pancreatitis. Disruption of the locus that encodes cationic trypsi
Publikováno v:
Gastroenterology
Background and Aims Visceral hypersensitivity is common in patients with irritable bowel syndrome (IBS). We investigated whether inflammatory molecules, such as histamine and proteases, activate prostaglandin-endoperoxide synthase 2 (also called COX2
Autor:
Giovanni Barbara, Yuri A. Saito, Mauro D'Amato, Greger Lindberg, Massimo Bellini, Nicholas J. Talley, Piero Portincasa, Rosario Cuomo, Weronica E. Ek, Cheryl E. Bernard, Gerardo Nardone, Aldona Dlugosz, Arthur Beyder, Pontus Karling, G. Richard Locke, Maria Gazouli, Michael J. Ackerman, Peter T. Schmidt, Bodil Ohlsson, Matteo Neri, Michael Camilleri, David J. Tester, Peter R. Strege, Felicity Enders, Paolo Usai-Satta, Francesca Galeazzi, Gianrico Farrugia, Amelia Mazzone
Publikováno v:
Gastroenterology. 146:1659-1668
BACKGROUND & AIMS: SCN5A encodes the α-subunit of the voltage-gated sodium channel NaV1.5. Many patients with cardiac arrhythmias caused by mutations in SCN5A also have symptoms of irritable bowel syndrome (IBS). We investigated whether patients wit
Autor:
Martin J. Shearer
Publikováno v:
Gastroenterology. 137:S105-S118
Vitamin K (as phylloquinone and menaquinones) is an essential cofactor for the conversion of peptide-bound glutamate to gamma-carboxy glutamic acid (Gla) residues in a number of specialized Gla-containing proteins. The only unequivocal deficiency out
Autor:
Vlad, Ratziu, Philippe, Giral, Sophie, Jacqueminet, Fréderic, Charlotte, Agnès, Hartemann-Heurtier, Lawrence, Serfaty, Philippe, Podevin, Jean-Marc, Lacorte, Carole, Bernhardt, Eric, Bruckert, André, Grimaldi, Thierry, Poynard, Jacqueline, Capeau
Publikováno v:
Gastroenterology. 135:100-110
Nonalcoholic steatohepatitis (NASH) is a liver disease that complicates insulin-resistant states. This trial tested the efficacy and safety of rosiglitazone, an insulin-sensitizing agent, in patients with NASH.Sixty-three patients with histologically
Autor:
Katharine R. Judge, Francis M. Giardiello, Robert A. Casero, Deborah E. Geiman, Linda M. Hylind, G. Johan A. Offerhaus, Vincent W. Yang, Jill D. Trimbath, Walter C. Hubbard, Stanley R. Hamilton
Publikováno v:
Gastroenterology, 126(2), 425-431. W.B. Saunders Ltd
Background & Aims: Familial adenomatous polyposis because of germline mutation of the adenomatous polyposis coli gene is characterized by development of colorectal adenomas and, ultimately, colorectal cancer. The usefulness of colorectal mucosal comp
Autor:
James Haorah, Xian–Zhong Ding, Alexis Ulrich, Thomas E. Adrian, Matthias B. Schneider, Parviz M. Pour, Hosei Matsuzaki, Jens Standop
Publikováno v:
Gastroenterology. 120:1263-1270
Our previous study suggested that the known promotional effect of a high fat diet, which in hamsters induces peripheral insulin resistance, is related to a compensatory proliferation of islet cells. The present study was to examine whether the preven
Publikováno v:
Gastroenterology. 119:670-676
Background & Aims: Omeprazole is metabolized by cytochrome P450 (CYP2C19). The activity of this enzyme is polymorphic, with incidences of poor metabolizers (PMs), heterozygous extensive metabolizers (EMs), and homozygous EMs in white populations of 3
Autor:
Masao Tanaka, Syoji Kuroki, Tokio Naito, Hiroyuki Yamashita, Hironori Sakai, Shuichiro Okamoto, Kazuo Chijiiwa
Publikováno v:
Gastroenterology. 112:1277-1283
BACKGROUND & AIMS: Serum 7alpha-hydroxycholesterol level reflects hepatic bile acid synthesis in humans. The aim of this study was to examine the maximal bile acid synthesis in patients with chronic liver diseases. METHODS: Cholestyramine (12 g/day)
Autor:
Iwao Sasaki, Seiki Matsuno, Noriya Ohtani, Michinaga Takahashi, Chikashi Shibata, Hiroo Naito, Takashi Tsuchiya
Publikováno v:
Gastroenterology. 109:1197-1205
Background & Aims: Capsaicin is known to contract smooth muscles and to have an excitatory action on thin, primary afferent neurons. The aim of this study was to test the hypothesis that intragastric capsaicin may have an excitatory effect on colonic