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Publikováno v:
Fundamentalclinical pharmacology. 33(3)
There is a growing number of epidemiological and molecular studies which suggest that diabetes is associated with an increased risk of Parkinson's disease (PD). Hence, in this study, the effect of glimepiride (GPD), a sulphonylurea (antidiabetic) on
Publikováno v:
Fundamentalclinical pharmacology. 31(5)
Heme oxygenase (HO)-1 has exhibited nephro-protective actions in different animal models; however, its full mechanistic potential in diabetic nephropathy (DN) has not yet been elucidated. Hence, the present study has been undertaken by inducing DN in
Publikováno v:
Fundamentalclinical pharmacology. 29(3)
Cyclophosphamide (CYP) is a chemotherapeutic agent with a potent ovarian toxic effect. CYP induces granulosa cell apoptosis and oxidative stress. Irbesartan (IRB) is a unique ARB with a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agoni
Publikováno v:
Fundamentalclinical pharmacology. 27(6)
This study investigated the role of K(ATP) channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain. The K(ATP) channel modulators (K(ATP) channel opener, diazoxide 100 mg/kg, p.o, and K(ATP) channel bl
Publikováno v:
Fundamentalclinical pharmacology. 24(1)
Free radicals are highly reactive species which played an important role in the pathogenesis of acute inflammation. In this study, the protective role of the known antioxidant, thioctic acid, in carrageenan-induced acute inflammation in rats was asse
Publikováno v:
Fundamentalclinical pharmacology. 23(5)
The present study was undertaken to investigate possible mechanism of pioglitazone-induced beneficial effect in memory deficits associated with experimental dementia. Dementia was induced in Swiss albino mice by administration of streptozotocin (STZ;
Autor:
Anil Kumar, Ruchika Garg
Publikováno v:
Fundamentalclinical pharmacology. 23(1)
Chronic fatigue syndrome (CFS) is characterized by profound fatigue, which substantially interferes with daily activities. The aim of this study was to explore the protective effects of antidepressants in an animal model of CFS in mice. Male albino m
Publikováno v:
Fundamentalclinical pharmacology. 21(3)
Systemic administration of 3-nitropropionic acid (3-NP), a complex II inhibitor of the electron transport chain, causes motor and cognitive deficits that are associated with excitotoxicity and excessive free radical generation. Recently, cyclooxygena
Autor:
Yesim Ipci, A. Özer Şehirli, Esra Çikler, İnci Alican, Göksel Şener, Şule Çetinel, Nursal Gedik
Publikováno v:
Fundamentalclinical pharmacology. 19(2)
Experiments have shown that chronic nicotine administration caused oxidative damage in various organs by increasing lipid peroxidation products and decreasing the activity of endogenous antioxidants. The aim of this study was to investigate the effec
Publikováno v:
Fundamentalclinical pharmacology. 19(1)
Previous studies suggest that a link exists between increased oxidative stress and diabetic neuropathy. Moreover, antioxidants may protect neurones from the degenerative effects of reactive oxygen species. In our study, we used streptozotocin (STZ)-d