Zobrazeno 1 - 10
of 38
pro vyhledávání: ''
Autor:
M. A. Mauney, B Collins, Robert E. Chapin, Virginia C. Moser, Ralph E. Wilson, Leo T. Burka, B. J. Davis, Ann C. Lockhart, Sandra M. Ward, Ralph J. Smialowicz, Martha W. Harris
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 40(1)
In order to address data gaps identified by the NAS report Pesticides in the Diets of Infants and Children, a study was performed using methoxychlor (MXC). Female rats were gavaged with MXC at 0, 5, 50, or 150 mg/kg/day for the week before and the we
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 17(2)
Chloroacetic acids are produced in drinking water as a result of disinfection processes. Chloroacetic acids are also metabolites of widely used and toxic halogenated hydrocarbons. Thus, chronic human exposure to these chemicals is likely to occur. Th
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 16(1)
The effect of multiple oral administration of MOCA, a suspect human carcinogen, was studied in the adult male rat. As many as 28 consecutive daily doses of [14C]MOCA at 28.1 mumol/kg body wt (5 microCi/day) were administered and rats were euthanized
Autor:
Zakaria Z. Wahba, Michael P. Waalkes
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 15(4)
Recent studies have shown that Cd-induced testicular interstitial cell (TIC) tumors can be prevented by low-dose Cd pretreatment. However, the mechanism by which low-dose Cd induces such tolerance is unclear. Thus, in this study we assessed the effec
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 14(4)
The effects of environmental temperature on body temperature and neuroendocrine parameters were evaluated following a single acute dose (60 micrograms/kg) of soman. Plasma levels of corticosterone, glucose, and free fatty acids, as well as acetylchol
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 14(1)
The toxicity of temelastine 2-[4-(5-bromo-3-methylpyrid-2-yl)butylamino]-5-[(6-methylpyrid+ ++-3-yl) methyl]-4-pyrimidone a potent, selective, competitive histamine H1-receptor antagonist was examined in dogs and rats. The major toxicological respons
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 12(3)
The protective ratio produced by HI-6 (with atropine) against soman and tabun poisoning in rats and guinea pigs was determined. The amount of protection afforded by HI-6 decreased with time following poisoning, prompting us to examine the effects of
Autor:
C. Hampton, D.J. Sprinkle, John P. Gibson, K.W. Huffman, G.J. Wright, David E. Loudy, G. A. Leeson, John T. Yarrington
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 3(2)
The ferrocene hematinic MDL 80,478 was administered orally at dosages ranging from 0 to 500 mg/kg/day to dogs (2 weeks), monkeys (6 weeks), and rats (6 weeks). Rats given 500 mg/kg/day had distended abdomens due to enlarged livers while the high-dose
Autor:
George C. Jersey, Rebecca L. Adams, Mary L. McClintock, Anne M. Mueller, Virginia A. Linscombe, Anil K. Sinha
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 3(2)
This report presents the cytogenetic findings in bone marrow cells of rats exposed to styrene vapor. Male and female Sprague-Dawley rats were exposed to 0, 600 and 1000 ppm of styrene vapor by inhalation 6 hr per day, 5 days a week, for a period of o
Autor:
Steven A. Lerman, Thomas W. Clarkson
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 3(4)
Differences in distribution and metabolism of arsenite and arsenate were studied in rats and in rat liver and kidney slices and hepatocytes. Five minutes after i.v. administration of 4.8 nmol arsenite or arsenate to male Sprague-Dawley rats, blood le