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Publikováno v:
Fundamental & Clinical Pharmacology. 6:99-111
We have examined the actions of a novel xanthine derivative, propentofylline (HWA 285), that has been shown to protect against ischemic brain damage in rats and gerbils, on adenosine receptors (A1 and A2), and on adenosine transporters using several
Publikováno v:
Fundamental & Clinical Pharmacology. 5:497-502
Summary— The time course of 5-hydroxytryptophan (5-HTP), serotonin (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in four rat brain areas (hypothalamus, hippocampus, striatum and olfactory bulbs) were investigated after treatment wi
Publikováno v:
Fundamental & Clinical Pharmacology. 5:319-329
The effects of the aqueous extract of leaves of Bridelia atroviridis (Bridelia), a small African tree, on the mechanical activity of rat uterus were studied. The aqueous extract of leaves of B atroviridis administered in a concentration-dependent man
Autor:
MT Ristori, J. Verdetti
Publikováno v:
Fundamental & Clinical Pharmacology. 5:245-258
Summary— The effects of taurine on vascular tone of isolated thoracic aortic rings were investigated. We have observed that: 1) taurine is able to induce reduction of the basal contractile tone; 2) taurine exerts a relaxing action in artery segment
Publikováno v:
Fundamental & Clinical Pharmacology. 5:107-115
The binding of the potent oral antidiabetic sulphonylurea [3H]glibenclamide was studied in rat cerebral cortex membranes. A single population of high affinity and saturable binding sites with equilibrium constants, Kd = 0.2 +/- 0.06 nM and Bmax = 58.
Publikováno v:
Fundamental & Clinical Pharmacology. 5:25-38
The mechanism(s) responsible for arterial vasodilation observed following acute administration of racemic carvedilol, a novel vasodilator/beta adrenoceptor antagonist, has been investigated in rats. In conscious spontaneously hypertensive rats, carve
Autor:
TS Emudianughe
Publikováno v:
Fundamental & Clinical Pharmacology. 4:483-489
The metabolism of salicylic acid was studied in male and female streptozotocin-induced diabetic Wistar rats. Results obtained showed that in both sexes there was a significant increase in urinary excretion of salicyluric acid in diabetic rats when co
Autor:
S A Persson, T Mjörndal
Publikováno v:
Fundamental & Clinical Pharmacology. 4:213-222
A single dose of perphenazine (5.0 mg/kg) was administered intraperitoneally to male Wistar rats. The time-related alterations in serum levels of perphenazine, striatal 3H-spiperone binding ex vivo and the regional brain metabolism of dopamine and 5-
Publikováno v:
Fundamental & Clinical Pharmacology. 5:139-141
Publikováno v:
Fundamental & Clinical Pharmacology. 1:409-412
Summary— The influence of ageing on demethylation of 14C-aminopyrine (AP) and 14C-caffeine (Caf) in Wistar littermate rats was studied serially using the 14CO2-breath test. In both sexes, the elimination half-life (t1/2) of 14C-AP fell from a mean