Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Guang Chen"'
Autor:
Ke-Guang Chen, Ye-Hui Zhang, Pan-Pan Ye, Xue-Hu Gao, Lin-Lin Song, Hai-Yan Zhou, Qian Li, Fu-Rong Zhao, Jin-Yi Shi, Xin-Mei Yang, Kai Shen, Sheng Feng, Wei Zhao
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Objectives: INS068 is a novel, soluble, and long-acting insulin analog. In this study, we evaluated the pharmacokinetics and relative bioavailability of two formulations of INS068 in healthy Chinese subjects: a reference formulation packaged in vials
Externí odkaz:
https://doaj.org/article/f45dc0a27fd447838e79e84cb91c38fc
Autor:
Hai-Jun Li, Dan-Qing Li, Yu-Liang Zhang, Xiao-Fei Ding, Hai-Tao Gao, Ya Zhu, Jun Liu, Li-Xia Zhang, Jie Chen, Guang Chen, Ying Yu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Gut microbiota affects the gut–brain axis; hence, the modulation of the microbiota has been proposed as a potential therapeutic strategy for cerebral ischemia/reperfusion injury (CIRI). However, the role and mechanism of the gut microbiota in regul
Externí odkaz:
https://doaj.org/article/3ba6917b54714947a817a5f299585aa7
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Backgrounds: The incidence of melanosis coli (MC) has gradually increased annually, attracting significant attention and efforts into this field. A potential risk for MC is the long-term use of anthraquinone laxatives in patients with constipation. M
Externí odkaz:
https://doaj.org/article/c8847fd9fcfe4e0aa45cde6e9499705a
Autor:
Xu Cao, Hening Chen, Zhiguo Li, Xiaoke Li, Xianzhao Yang, Qiushuo Jin, Yijun Liang, Jiaxin Zhang, Meiyue Zhou, Ningyi Zhang, Guang Chen, Hongbo Du, Xiaobin Zao, Yong’an Ye
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The Chinese traditional medicine KangXianYiAi formula (KXYA) is used to treat hepatic disease in the clinic. Here we aim to confirm the therapeutic effects and explore the pharmacological mechanisms of KXYA on hepatitis B virus (HBV)-related hepatoce
Externí odkaz:
https://doaj.org/article/49c002ce77f0494894a0fe09a5485762
Autor:
Xu Cao, Yijun Liang, Ruijia Liu, Xiaobin Zao, Jiaying Zhang, Guang Chen, Ruijie Liu, Hening Chen, Yannan He, Jiaxin Zhang, Yong’an Ye
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Liver cirrhosis (LC) is a fibrotic lesion of liver tissue caused by the repeated progression of chronic hepatitis. The traditional Chinese medicine Gexia-Zhuyu formula (GXZY) has a therapeutic effect on LC. However, its pharmacological mechanisms on
Externí odkaz:
https://doaj.org/article/2d4d89c1294043f5ac2cdbf96879b85c
Autor:
Jie Chen, Jin Zhu, Shuai-Jun Xu, Jun Zhou, Xiao-Fei Ding, Yong Liang, Guang Chen, Hong-Sheng Lu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: The prognosis of breast cancer varies according to the molecular subtype. Transmembrane 4 L six family 1 (TM4SF1) exhibits different expression patterns among the molecular subtypes of breast cancer. However, the expression profile of TM4
Externí odkaz:
https://doaj.org/article/bec11ceab1e14242b361928fc48c5901
Autor:
Guoxiang Liu, Lina Yang, Guang Chen, Fenghua Xu, Fanghao Yang, Huaxin Yu, Lingne Li, Xiaolei Dong, Jingjing Han, Can Cao, Jingyu Qi, Junzhe Su, Xiaohui Xu, Xiaoxia Li, Bing Li
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
In recent years, with the development of nanomaterials, the research of drug delivery systems has become a new field of cancer therapy. Compared with conventional antitumor drugs, drug delivery systems such as drug nanoparticles (NPs) are expected to
Externí odkaz:
https://doaj.org/article/a058af5f5c694b2880a44e1f1d07666c
Autor:
Fan Wu, Yan Zhao, Qingqing Shao, Ke Fang, Ruolan Dong, Shujun Jiang, Fuer Lu, Jinlong Luo, Guang Chen
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Objectives: Natural product, osthole, has been proven to have a protective effect on organ fibrosis, including renal fibrosis. All of these studies are mainly focused on the regulation of TGF-β/Smad signaling pathway. However, due to the pleiotropic
Externí odkaz:
https://doaj.org/article/e70d599c206b4e84a7ad19b386696a3a
Autor:
Wei-Qiang Yang, Wei-Jun Zhao, Liu-Lian Zhu, Shuai-Jun Xu, Xue-Lin Zhang, Yong Liang, Xiao-Fei Ding, Alexander Kiselyov, Guang Chen
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Doublecortin-like kinase 1 (DCLK1) is a cancer stem cell marker that is highly expressed in various types of human cancer, and a protein kinase target for cancer therapy that is attracting increasing interest. However, no drug candidates targeting DC
Externí odkaz:
https://doaj.org/article/f8f940c9355e45038379314049eabcfd
Autor:
Meng Li, Li Hao, Lei Li, Lei Liu, Guang Chen, Wei Jiang, Wei Xu, Chen Zhu, Gang Yao, Shiyuan Fang
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Osteoporosis (OP) is one of the common bone metabolic diseases that endangers postmenopausal women and the elders. Both excessive bone resorption caused by osteoclast over-activation and increased oxidative stress are associated with osteoporosis. Ci
Externí odkaz:
https://doaj.org/article/2297b05d6e6c4d58a116c8ad57f6e3d0