Zobrazeno 81 - 90
of 153
pro vyhledávání: '"11"'
Autor:
Francesca Fagiani, Michele Catanzaro, Erica Buoso, Filippo Basagni, Daniele Di Marino, Stefano Raniolo, Marialaura Amadio, Eric H. Frost, Emanuela Corsini, Marco Racchi, Tamas Fulop, Stefano Govoni, Michela Rosini, Cristina Lanni
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The transcription factor Nrf2 coordinates a multifaceted response to various forms of stress and to inflammatory processes, maintaining a homeostatic intracellular environment. Nrf2 anti-inflammatory activity has been related to the crosstalk with th
Externí odkaz:
https://doaj.org/article/4b7dc9e5773142e4a45a0d02ec68629f
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
BackgroundNephrolithiasis is a systemic metabolic disease with a high prevalence worldwide and is closely related to lipid-mediated oxidative stress and inflammation. Orthosiphon stamineus Benth. (OS) is a traditional medicinal herb mainly containing
Externí odkaz:
https://doaj.org/article/6ce7c484a0a547b2a4f8aaf7453d4123
Autor:
Ting-Ting Cai, Xiao-Long Ye, Ru-Run Li, Hui Chen, Ya-Yun Wang, Hui-Juan Yong, Ming-Lin Pan, Wei Lu, Ying Tang, Heng Miao, Antoine M. Snijders, Jian-Hua Mao, Xing-Yin Liu, Yi-Bing Lu, Da-Fa Ding
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Oral administration of resveratrol is able to ameliorate the progression of diabetic nephropathy (DN); however, its mechanisms of action remain unclear. Recent evidence suggested that the gut microbiota is involved in the metabolism therapeutics. In
Externí odkaz:
https://doaj.org/article/16448da9f07247cbaf5ef25daa01d929
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Leukotrienes are biologically active eicosanoid lipid mediators that originate from oxidative metabolism of arachidonic acid. Biosynthesis of leukotrienes involves a set of soluble and membrane-bound enzymes that constitute a machinery complex primar
Externí odkaz:
https://doaj.org/article/cc9d09d1b8134410a1b9afb69c72806a
Autor:
Ahmed L. Alaofi
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Diabetic neuropathy (DN) is a complicated inauspicious outcome of diabetes, like other abnormalities of diabetes the cause of DN is still vague and it may be the result of various pathological conditions leading up to end-stage renal failure. The pre
Externí odkaz:
https://doaj.org/article/62cb81849b874082a583de8d96b2ad00
Autor:
Francesca Lazzara, Maria Consiglia Trotta, Chiara Bianca Maria Platania, Michele D’Amico, Francesco Petrillo, Marilena Galdiero, Carlo Gesualdo, Settimio Rossi, Filippo Drago, Claudio Bucolo
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Retinal hypoxia is one of the causative factors of diabetic retinopathy and is also one of the triggers of VEGF release. We hypothesized that specific dysregulated miRNAs in diabetic retinopathy could be linked to hypoxia-induced damage in human reti
Externí odkaz:
https://doaj.org/article/4135089e63894410b0059896aa16590e
Autor:
Liliya N. Kirpotina, Igor A. Schepetkin, Deepa Hammaker, Amanda Kuhs, Andrei I. Khlebnikov, Mark T. Quinn
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Rheumatoid arthritis (RA) is a chronic autoimmune disease involving joint and bone damage that is mediated in part by proteases and cytokines produced by synovial macrophages and fibroblast-like synoviocytes (FLS). Although current biological therape
Externí odkaz:
https://doaj.org/article/1eb01e0aff4d43f9a67b06cf37022a28
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The increase of Angiontesin-II (Ang-II), one of the key peptides of the renin-angiotensin system (RAS), and its binding to the Ang-II type 1 receptor (AT1R) during hypertension is a crucial mechanism leading to AD\AM17 activation. Among the reported
Externí odkaz:
https://doaj.org/article/ba05b6ff805e4af6941fd677994b88c3
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Taoren Honghua drug is a traditional Chinese medicinal drug used to treat cardiovascular disease. The aim of the study is to investigate the effects of Taoren Honghua drug on inflammation and atherosclerosis in ApoE knock-out mice and RAW264.7 cells.
Externí odkaz:
https://doaj.org/article/533dcde5018d4a829788eded156e4d89
Autor:
Viera Janosova, Vladimir Calkovsky, Heiko Pedan, Estera Behanova, Andrej Hajtman, Andrea Calkovska
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Allergic rhinitis/rhinosinusitis (AR) is the most common allergic disease. It affects patients’ quality of life and may influence the severity of lower airway disease such as asthma. Therefore, its treatment is of great importance. AR is treated by
Externí odkaz:
https://doaj.org/article/fead4507656045cc9bdecde8413530bb