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Autor:
Hao Cheng, Yaohan Xu, Ziqi Zou, Ping Xu, Jiang Zhu, Yinjing Song, Jingyi Hu, Lihua Lai, Yueling Zhao
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Psoriasis, the most common skin inflammatory disease, is characterized by massive keratinocyte proliferation and immune cell infiltration into epidermis. L-Theanine (L-THE), a nonproteinogenic amino acid derived from green tea (Camellia sinensis), ha
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Tubulointerstitial fibrosis is one of the most common pathological features of diabetic nephropathy. Autophagy, an intracellular mechanism to remove damaged or dysfunctional cell parts and maintain metabolic homeostasis, is inhibited in diabetic neur
Autor:
Esperanza Herradón, Cristina González, Antonio González, Jose Antonio Uranga, Visitación López-Miranda
Publikováno v:
Frontiers in Pharmacology
Digital.CSIC. Repositorio Institucional del CSIC
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Frontiers in Pharmacology, Vol 12 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Frontiers in Pharmacology, Vol 12 (2021)
Vincristine is an effective anticancer agent for treating leukemias, lymphomas, and other solid tumors. Vincristine’s better-known severe side effects include bone marrow depression, hyponatremia, peripheral neuropathy, and gastrointestinal distres
Autor:
Chuang Xiao, Sha Cheng, Zifeng Yang, Rong Huang, Yutao Wang, Deyou Zeng, Hanxiao Pan, Yan Fang, Rongping Zhang, Chen Chen, Haiming Jiang, Weimin Yang, Runfeng Li, Xinhua Wang, Li Xian, Yaping Liang, Xiao Wu
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Chronic obstructive pulmonary disease (COPD), a major cause of morbidity and mortality worldwide, is widely considered to be related to cigarette smoke (CS), and viral infections trigger acute exacerbation of COPD (AECOPD). Isoforskolin (ISOF) is a b
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
Intervertebral disc degeneration (IDD) is related to the deterioration of nucleus pulposus (NP) cells due to hypertrophic differentiation and calcification. The imbalance of pro-inflammatory (M1 type) and anti-inflammatory (M2 type) macrophages contr
Autor:
Zhiping Zhao, Changyao Wang, Yingxing Xu, Xiangyu Wang, Bin Jia, Tengbo Yu, Yingzhen Wang, Yongtao Zhang
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
Wear particles may induce osteoclast formation and osteoblast inhibition that lead to periprosthetic osteolysis (PPOL) and subsequent aseptic loosening, which is the primary reason for total joint arthroplasty failure. Local bone renin-angiotensin sy
Autor:
Bing’e Ma, Dexuan Chen, Yangjing Liu, Zhengping Zhao, Jianhua Wang, Guowei Zhou, Kun Xu, Taiyang Zhu, Qiong Wang, Chaoqun Ma
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
Inflammation is an important contributor to autoimmune thyroiditis. Yanghe decoction (YH) is a traditional Chinese herbal formulation which has various anti-inflammatory effects. It has been used for the treatment of autoimmune diseases such as ankyl
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Allergic asthma is a typical chronic inflammatory disease of respiratory tract. Clinical data shows that patients with allergic asthma have different degrees of cognitive dysfunction. The molecular mechanism underlying the pathogenesis of asthma-indu
Autor:
Xiaoli Du, Qianqian Tao, Hongxia Du, Zhenbang Zhao, Yu Dong, Shuang He, Rui Shao, Yule Wang, Wenrun Han, Xintong Wang, Yan Zhu
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
BACKGROUND: Hypertension-induced renal damage is a serious and complex condition that has not been effectively treated by conventional blood pressure-lowering drugs. Tengdan capsule (TDC) is a China FDA-approved compound herbal medicine for treating
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
Long noncoding RNA (lncRNAs) metastasis–associated lung adenocarcinoma transcript 1 (MALAT1) has been reported in diabetic nephropathy (DN) about its effect on podocyte function and cell heat shock induced by hyperglycemia. However, the biological