Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Luigi D. Notarangelo"'
Autor:
Julie Brault, Taylor Liu, Siyuan Liu, Amanda Lawson, Uimook Choi, Nikita Kozhushko, Vera Bzhilyanskaya, Mara Pavel-Dinu, Ronald J. Meis, Michael A. Eckhaus, Sandra S. Burkett, Marita Bosticardo, Benjamin P. Kleinstiver, Luigi D. Notarangelo, Cicera R. Lazzarotto, Shengdar Q. Tsai, Xiaolin Wu, Gary A. Dahl, Matthew H. Porteus, Harry L. Malech, Suk See De Ravin
Publikováno v:
Frontiers in Immunology. 13
IntroductionEx vivo gene therapy for treatment of Inborn errors of Immunity (IEIs) have demonstrated significant clinical benefit in multiple Phase I/II clinical trials. Current approaches rely on engineered retroviral vectors to randomly integrate c
Autor:
Peter D, Burbelo, Riccardo, Castagnoli, Chisato, Shimizu, Ottavia M, Delmonte, Kerry, Dobbs, Valentina, Discepolo, Andrea, Lo Vecchio, Alfredo, Guarino, Francesco, Licciardi, Ugo, Ramenghi, Emma, Rey-Jurado, Cecilia, Vial, Gian Luigi, Marseglia, Amelia, Licari, Daniela, Montagna, Camillo, Rossi, Gina A, Montealegre Sanchez, Karyl, Barron, Blake M, Warner, John A, Chiorini, Yazmin, Espinosa, Loreani, Noguera, Lesia, Dropulic, Meng, Truong, Dana, Gerstbacher, Sayonara, Mató, John, Kanegaye, Adriana H, Tremoulet, Eli M, Eisenstein, Helen C, Su, Luisa, Imberti, Maria Cecilia, Poli, Jane C, Burns, Luigi D, Notarangelo, Stacey, Ulrich
Publikováno v:
Frontiers in immunology. 13
The antibody profile against autoantigens previously associated with autoimmune diseases and other human proteins in patients with COVID-19 or multisystem inflammatory syndrome in children (MIS-C) remains poorly defined. Here we show that 30% of adul
Autor:
Kevin M. Vannella, Cihan Oguz, Sydney R. Stein, Stefania Pittaluga, Esra Dikoglu, Arjun Kanwal, Sabrina C. Ramelli, Thomas Briese, Ling Su, Xiaolin Wu, Marcos J. Ramos-Benitez, Luis J. Perez-Valencia, Ashley Babyak, Nu Ri Cha, Joon-Yong Chung, Kris Ylaya, Ronson J. Madathil, Kapil K. Saharia, Thomas M. Scalea, Quincy K. Tran, Daniel L. Herr, David E. Kleiner, Stephen M. Hewitt, Luigi D. Notarangelo, Alison Grazioli, Daniel S. Chertow
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
A 26-year-old otherwise healthy man died of fulminant myocarditis. Nasopharyngeal specimens collected premortem tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathological evaluation of the heart showed myocard
Autor:
Michael Tsui, Weixian Min, Stephanie Ng, Kerry Dobbs, Luigi D. Notarangelo, Yigal Dror, Eyal Grunebaum
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Inherited defects that abrogate the function of the adenosine deaminase (ADA) enzyme and consequently lead to the accumulation of toxic purine metabolites cause profound lymphopenia and severe combined immune deficiency. Additionally, neutropenia and
Autor:
Jenna R.E. Bergerson, Tom DiMaggio, Elise M. N. Ferré, Monica M. Schmitt, Luigi D. Notarangelo, Michail S. Lionakis, Sebastian Ochoa, Jennifer Stoddard, Shakuntala Rampertaap, Sergio D. Rosenzweig, Peter D. Burbelo, Elana R. Shaw, Steven M. Holland, Lindsey B. Rosen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Patients with the monogenic immune dysregulatory syndrome autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), which is caused by loss-of-function mutations in the autoimmune regulator (AIRE) gene, uniformly carry neutralizing aut
Autor:
Christoph B. Geier, Jocelyn R. Farmer, Zsofia Foldvari, Boglarka Ujhazi, Jolanda Steininger, John W. Sleasman, Suhag Parikh, Meredith A. Dilley, Sung-Yun Pai, Lauren Henderson, Melissa Hazen, Benedicte Neven, Despina Moshous, Svetlana O. Sharapova, Snezhina Mihailova, Petya Yankova, Elisaveta Naumova, Seza Özen, Kevin Byram, James Fernandez, Hermann M. Wolf, Martha M. Eibl, Luigi D. Notarangelo, Leonard H. Calabrese, Jolan E. Walter
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Vasculitis can be a life-threatening complication associated with high mortality and morbidity among patients with primary immunodeficiencies (PIDs), including variants of severe and combined immunodeficiencies ((S)CID). Our understanding of vasculit
Autor:
Emma Westermann-Clark, Jennifer W. Leiding, Jolan E. Walter, Maria Chitty-Lopez, Kerry Dobbs, Boglarka Ujhazi, Khuong Le, Deepak Chellapandian, Yasuhiro Yamazaki, Krisztian Csomos, Luigi D. Notarangelo, Irina Dawson, Amir A. Sadighi Akha, Gauri Sunkersett, Ben Oshrine
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
The T-cell receptor excision circle (TREC) assay detects T-cell lymphopenia (TCL) in newborns and is especially important to identify severe combined immunodeficiency (SCID). A spectrum of SCID variants and non-SCID conditions that present with TCL a
Autor:
Taisuke Kondo, Francesca Pala, Sarah Gailhac, Naomi Taylor, Vanessa Fritz, Alice Machado, Uriel López-Sánchez, Vincent Petit, Luigi D. Notarangelo, Marita Bosticardo, Valérie S. Zimmermann, Marco Craveiro, Marie Pouzolles
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2020, ⟨10.3389/fimmu.2020.01562⟩
Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2020, ⟨10.3389/fimmu.2020.01562⟩
Thymocyte differentiation is dependent on the availability and transport of metabolites in the thymus niche. As expression of metabolite transporters is a rate-limiting step in nutrient utilization, cell surface transporter levels generally reflect t
Autor:
Svetlana O. Sharapova, Małgorzata Skomska-Pawliszak, Yulia A. Rodina, Beata Wolska-Kuśnierz, Nel Dabrowska-Leonik, Bozena Mikołuć, Olga E. Pashchenko, Srdjan Pasic, Tomáš Freiberger, Tomáš Milota, Renata Formánková, Anna Szaflarska, Maciej Siedlar, Tadej Avčin, Gašper Markelj, Peter Ciznar, Krzysztof Kalwak, Sylwia Kołtan, Teresa Jackowska, Katarzyna Drabko, Alenka Gagro, Małgorzata Pac, Elissaveta Naumova, Snezhina Kandilarova, Katarzyna Babol-Pokora, Dzmitry S. Varabyou, Barbara H. Barendregt, Elena V. Raykina, Tatiana V. Varlamova, Anna V. Pavlova, Hana Grombirikova, Maruša Debeljak, Irina V. Mersiyanova, Anastasiia V. Bondarenko, Liudmyla I. Chernyshova, Larysa V. Kostyuchenko, Marina N. Guseva, Jelena Rascon, Audrone Muleviciene, Egle Preiksaitiene, Christoph B. Geier, Alexander Leiss-Piller, Yasuhiro Yamazaki, Tomoki Kawai, Jolan E. Walter, Irina V. Kondratenko, Anna Šedivá, Mirjam van der Burg, Natalia B. Kuzmenko, Luigi D. Notarangelo, Ewa Bernatowska, Olga V. Aleinikova
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, 11:900. Frontiers Media S.A.
Frontiers in Immunology
Frontiers in immunology, Lausanne : Frontiers Media SA, 2020, vol. 11, art. no. 900, p. [1-13]
Frontiers in Immunology, 11. FRONTIERS MEDIA SA
Frontiers in Immunology, 11:900. Frontiers Media S.A.
Frontiers in Immunology
Frontiers in immunology, Lausanne : Frontiers Media SA, 2020, vol. 11, art. no. 900, p. [1-13]
Frontiers in Immunology, 11. FRONTIERS MEDIA SA
Background: Variants in recombination-activating genes (RAG) are common genetic causes of autosomal recessive forms of combined immunodeficiencies (CID) ranging from severe combined immunodeficiency (SCID), Omenn syndrome (OS), leaky SCID, and CID wi
Autor:
Alice Y. Chan, Jennifer W. Leiding, Xuerong Liu, Brent R. Logan, Lauri M. Burroughs, Eric J. Allenspach, Suzanne Skoda-Smith, Gulbu Uzel, Luigi D. Notarangelo, Mary Slatter, Andrew R. Gennery, Angela R. Smith, Sung-Yun Pai, Michael B. Jordan, Rebecca A. Marsh, Morton J. Cowan, Christopher C. Dvorak, John A. Craddock, Susan E. Prockop, Shanmuganathan Chandrakasan, Neena Kapoor, Rebecca H. Buckley, Suhag Parikh, Deepak Chellapandian, Benjamin R. Oshrine, Jeffrey J. Bednarski, Megan A. Cooper, Shalini Shenoy, Blachy J. Davila Saldana, Lisa R. Forbes, Caridad Martinez, Elie Haddad, David C. Shyr, Karin Chen, Kathleen E. Sullivan, Jennifer Heimall, Nicola Wright, Monica Bhatia, Geoffrey D. E. Cuvelier, Frederick D. Goldman, Isabelle Meyts, Holly K. Miller, Markus G. Seidel, Mark T. Vander Lugt, Rosa Bacchetta, Katja G. Weinacht, Jeffrey R. Andolina, Emi Caywood, Hey Chong, Maria Teresa de la Morena, Victor M. Aquino, Evan Shereck, Jolan E. Walter, Morna J. Dorsey, Christine M. Seroogy, Linda M. Griffith, Donald B. Kohn, Jennifer M. Puck, Michael A. Pulsipher, Troy R. Torgerson
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Primary Immune Regulatory Disorders (PIRD) are an expanding group of diseases caused by gene defects in several different immune pathways, such as regulatory T cell function. Patients with PIRD develop clinical manifestations associated with diminish