Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Guang Chen"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/f7e21a43f9d84f5db260f1ece2729cff
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Autoimmunity involves a loss of immune tolerance to self-proteins due to a combination of genetic susceptibility and environmental provocation, which generates autoreactive T and B cells. Genetic susceptibility affects lymphocyte autoreactivity at th
Externí odkaz:
https://doaj.org/article/770f4d98dcac44a3ab56512b76e0240f
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundBAFF production is increased in IBD patients. However, the specific role of BAFF in IBD is still uncovered. This study aimed to investigate the expression and function of BAFF in experimental colitis and the potential mechanisms.MethodsBAFF
Externí odkaz:
https://doaj.org/article/37ff1313d0e748e2b960ff90d980277d
Autor:
Melanie R. Shapiro, Wen-I Yeh, Joshua R. Longfield, John Gallagher, Caridad M. Infante, Sarah Wellford, Amanda L. Posgai, Mark A. Atkinson, Martha Campbell-Thompson, Scott M. Lieberman, David V. Serreze, Aron M. Geurts, Yi-Guang Chen, Todd M. Brusko
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The costimulatory molecule CD226 is highly expressed on effector/memory T cells and natural killer cells. Costimulatory signals received by T cells can impact both central and peripheral tolerance mechanisms. Genetic polymorphisms in CD226 have been
Externí odkaz:
https://doaj.org/article/7bccfa348d184824bd0a2ddaebeab0f9
Autor:
Arata Itoh, Lorenzo Ortiz, Kritika Kachapati, Yuehong Wu, David Adams, Kyle Bednar, Shibabrata Mukherjee, Claire Chougnet, Robert S. Mittler, Yi-Guang Chen, Laurence Dolan, William M. Ridgway
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
We show here that soluble CD137 (sCD137), the alternately spliced gene product of Tnfsfr9, effectively treats acute type 1 diabetes (T1D) in nonobese diabetic (NOD) mice. sCD137 significantly delayed development of end-stage disease, preserved insuli
Externí odkaz:
https://doaj.org/article/a1f4bc23defc4c90872138307eddea17
CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes
Autor:
Adam M. Sandor, Robin S. Lindsay, Nathan Dyjack, Jennifer C. Whitesell, Cydney Rios, Brenda J. Bradley, Kathryn Haskins, David V. Serreze, Aron M. Geurts, Yi-Guang Chen, Max A. Seibold, Jordan Jacobelli, Rachel S. Friedman
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Type 1 diabetes (T1D) is a T cell mediated autoimmune disease that affects more than 19 million people with incidence increasing rapidly worldwide. For T cells to effectively drive T1D, they must first traffic to the islets and extravasate through th
Externí odkaz:
https://doaj.org/article/84f626d760c74ffda3d49e544096b774
Publikováno v:
Frontiers in immunology. 13
BAFF production is increased in IBD patients. However, the specific role of BAFF in IBD is still uncovered. This study aimed to investigate the expression and function of BAFF in experimental colitis and the potential mechanisms.BAFF levels in the se
Publikováno v:
Frontiers in Immunology; 10/27/2022, Vol. 13, p1-3, 3p
Publikováno v:
Frontiers in Immunology; 7/22/2022, Vol. 13, p1-13, 13p
Autor:
Mishra, Arpit, Jajodia, Ajay, Weston, Eryn, Jayavelu, Naresh Doni, Garcia, Mariana, Hossack, Daniel, Hawkins, R. David
Publikováno v:
Frontiers in Immunology; 2024, p1-9, 9p