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Publikováno v:
Free radical research. 53(11-12)
Matrix metalloproteinases (MMPs), zinc-containing proteinases, play a critical role in tumour progression by degrading extracellular matrix components. MMP2 and MMP9 are secreted from tumour-associated macrophages as well as tumour cells and have bee
Publikováno v:
Free radical research. 52(4)
Hepatic sinusoidal obstruction syndrome (HSOS) is a rare and life-threatening liver disease. (+)-Catechin is a natural dietary flavonol with high antioxidant capacity. This study aims to investigate the involvement of nuclear factor erythroid 2-relat
Autor:
Jorge M. Barcia, María Miranda, Michela Sommavilla, Francisco J. Romero, Violeta Sanchez-vallejo, Inmaculada Almansa, M. Victoria Sánchez-Villarejo
Publikováno v:
Free Radical Research. 46:1076-1081
Binge alcohol consumption in adolescents is increasing, and it has been proposed that immature brain deals poorly with oxidative stress. The aim of our work was to study the effect of an acute dose of ethanol on glutathione (GSH) metabolism in fronta
Autor:
Sunyoung Hwang, Ji H. Lim, Yeong Sik Kim, Won Ki Kim, G. Cho, Yoo Keum Choi, Hyoung-Chun Kim, Byung Woo Kim, Jae Chul Lee
Publikováno v:
Free Radical Research. 44:925-935
The present study tested the cytoprotective effect of methyleugenol in an in vivo ischemia model (i.e. middle cerebral artery occlusion (MCAO) for 1.5 h and subsequent reperfusion for 24 h) and further investigated its mechanism of action in in vitro
Publikováno v:
Free Radical Research. 44:541-551
(S)-cis-verbenol, a natural metabolite from (-)-alpha-pinene of host pine tree, has been suggested to have anti-ischemic activity. However, the exact mechanism for the anti-ischemic activity of (S)-cis-verbenol remains unclear yet. In the present stu
Publikováno v:
Free Radical Research. 42:778-788
While some authors suggest that retinoids are potential anti-proliferative and antioxidant agents, evidence has suggested those present pro-oxidant properties, which might lead to malignant proliferation. These discordances stimulated one to investig
Publikováno v:
Free Radical Research. 40:986-992
We investigated hepatoprotective activity and antioxidant effect of the 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene that purified from Morus bombycis Koidzumi roots against CCl4-induced liver damage in rats. The 2,5-dihydroxy-4,3'-
Autor:
Esaú Floriano-Sánchez, Cleva Villanueva, Omar Noel Medina-Campos, Diana Rocha, Dolores Javier Sánchez-González, Noemí Cárdenas-Rodríguez, José Pedraza-Chaverrí
Publikováno v:
Free Radical Research. 40:523-533
The antioxidant nordihydroguaiaretic acid (NDGA) has recently become well known as a putative anticancer drug. In this paper, it was evaluated the in vitro peroxynitrite (ONOO(-)), singlet oxygen ((1)O(2)), hydroxyl radical (OH(v)), hydrogen peroxide
Publikováno v:
Free Radical Research. 40:827-835
S-Allyl-L-cysteine (SAC) has been shown to reduce ischemic injury due to its antioxidant activity. However, the antioxidant property of SAC has been controversial. The present study investigated the neuroprotective mechanism of SAC in cerebral ischem
Publikováno v:
Free Radical Research. 39:979-986
The involvement of xanthine oxidase (XO) in some reactive oxygen species (ROS) -mediated diseases has been proposed as a result of the generation of O*- and H2O2 during hypoxanthine and xanthine oxidation. In this study, it was shown that purified ra