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Publikováno v:
Free Radical Biology and Medicine. 44:1406-1419
Piperidine nitroxides such as TEMPOL act as antioxidants in vivo due to their interconversion among nitroxide, hydroxylamine, and oxoammonium derivatives, but the mechanistic details of these reactions are unclear. As mitochondria are a significant s
Autor:
Robin A.J. Smith, Ellen L. Robb, Lesley Larsen, Cameron Evans, Andrew M. James, Peter G. Finichiu, Jan Trnka, Michael P. Murphy, David S. Larsen, Tracy A. Prime, Thomas P. Bright
Publikováno v:
Free Radical Biology & Medicine
Mitochondrial oxidative damage contributes to a wide range of pathologies. One therapeutic strategy to treat these disorders is targeting antioxidants to mitochondria by conjugation to the lipophilic triphenylphosphonium (TPP) cation. To date only hy