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pro vyhledávání: '"Majer A"'
Autor:
Majer, Christina R., Jin, Lei, Scott, Margaret Porter, Knutson, Sarah K., Kuntz, Kevin W., Keilhack, Heike, Smith, Jesse J., Moyer, Mikel P., Richon, Victoria M., Copeland, Robert A., Wigle, Tim J.
Publikováno v:
In FEBS Letters 21 September 2012 586(19):3448-3451
Autor:
Sarah K. Knutson, Heike Keilhack, Robert A. Copeland, Margaret Porter Scott, Jesse Smith, Christina R. Majer, Kevin Wayne Kuntz, Victoria M. Richon, Mikel P. Moyer, Tim J. Wigle, Lei Jin
Publikováno v:
FEBS letters. 586(19)
Heterozygous point mutations at Y641 and A677 in the EZH2 SET domain are prevalent in about 10–24% of Non-Hodgkin lymphomas (NHL). Previous studies indicate that these are gain-of-function mutations leading to the hypertrimethylation of H3K27. Thes
Autor:
Cyril Bařinka, Jana Jirásková, Jan Konvalinka, Kvido Stříšovský, Camilo Rojas, Pavel Majer, Barbara S. Slusher
Publikováno v:
FEBS letters. 535(1-3)
D-Serine was previously identified in mammalian brain and was shown to be a co-agonist at the ‘glycine’ site of the N-methyl-D-aspartate (NMDA)-type receptors. Racemization of serine is catalyzed by serine racemase, a pyridoxal 5′-phosphate-dep
Akademický článek
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Autor:
Střıšovský, Kvido, Jirásková, Jana, Bařinka, Cyril, Majer, Pavel, Rojas, Camilo, Slusher, Barbara S., Konvalinka, Jan
Publikováno v:
FEBS Letters; Jan2003, Vol. 535 Issue 1-3, p44, 5p
Autor:
Martin Andreánsky, Jana Stehliková, Eva Gregorová, Milan Fábrys, Pavel Majer, Milan Souček, Petr Štrop, Jan Urban, Jan Konvalinka
Publikováno v:
FEBS Letters. (1):9-13
Truncation of a peptide substrate in the N-terminus and replacement of its scissile amide bond with a non-cleavable reduced bond results in a potent inhibitor of HIV-1 protease. A series of such inhibitors has been synthesized, and S2–S3′ subsite
Autor:
John W. Erickson, Donald G. Johnson, Bradley P. Kane, Leonid I. Suvorov, Pavel Majer, Jack R. Collins, Sergei V. Gulnik
Publikováno v:
FEBS Letters. (2):379-384
Cathepsin D is a lysosomal aspartic proteinase that has been implicated in several pathological processes such as breast cancer and Alzheimer's disease. We designed and synthesized a number of quenched fluorogenic substrates with P2 variations in the
Autor:
Gulnik, Sergei V., Suvorov, Leonid I., Majer, Pavel, Collins, Jack, Kane, Bradley P., Johnson, Donald G., Erickson, John W.
Publikováno v:
FEBS Letters; August 1997, Vol. 413 Issue: 2 p379-384, 6p
Autor:
Urban, Jan, Konvalinka, Jan, Stehliková, Jana, Gregorová, Eva, Majer, Pavel, Souček, Milan, Andreánsky, Martin, Fábrys, Milan, Štrop, Petr
Publikováno v:
FEBS Letters; February 1992, Vol. 298 Issue: 1 p9-13, 5p
Publikováno v:
FEBS Letters. (2):339-341
High hydrophobicity of the second amino acid N-terminal to the scissile bond (P2 residue) is generally considered to be the major factor in the specificity of the substrates for cysteine proteases of the papain family. To examine the catalytic contri