Zobrazeno 1 - 10
of 55
pro vyhledávání: '"John S"'
Publikováno v:
FEBS Letters. 511:65-68
Transforming growth factors-β (TGFβ1, 2 and 3) are secreted in a complex with their propeptides (latency-associated peptide 1 (LAP1), 2 and 3). TGFβ signaling requires the dissociation of LAP and TGFβ, a process termed latent TGFβ activation. Th
Publikováno v:
FEBS Letters. 444:155-159
Salmon insulin-like growth factor-I (sIGF-I) expression is, as in mammals, induced by growth hormone (GH). To elucidate the mechanism by which GH stimulates the transcription of the IGF-I gene, we transiently transfected Hep3B cells expressing the ra
Autor:
Michael T. Henzl, John S. Graham
Publikováno v:
FEBS Letters. 442:241-245
It is widely believed that β-parvalbumin (PV) isoforms are intrinsically less stable than α-parvalbumins, due to greater electrostatic repulsion and an abbreviated C-terminal helix. However, when examined by differential scanning calorimetry, the a
Autor:
John S. Sussenbach, Werner E.G. Müller, Alexey Y. Palamarchuk, Vadim M. Kavsan, P. Elly Holthuizen
Publikováno v:
FEBS Letters. 416:344-348
IGF-II plays an important role in growth and development of vertebrates. In the present study, the characterization of the first fish IGF-II gene, chum salmon IGF-II, is described. The sIGF-II gene consists of four exons, spanning a region of 9 kbp,
Publikováno v:
FEBS Letters. 408:57-61
The mechanism of the inhibition of sheep liver sorbitol dehydrogenase by the novel antidiabetogenic drug 2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine has been investigated by steady-state kinetics over the range pH 5–10. T
Publikováno v:
FEBS Letters. 404:283-288
The cloning and analysis of a cDNA clone encoding the soybean metalloproteinase obtained by polymerase chain reaction (PCR) and the rapid amplification of cDNA ends (RACE) reaction are described. The cDNA was constructed from poly(A) + RNA isolated f
Publikováno v:
FEBS Letters. 394:25-30
The adult liver-specific IGF-II promoter P1 is activated by CCAAT/Enhancer Binding Proteins α and β. Here we present evidence that promoter P1, in addition to positively regulating elements, contains two elements of 67 nucleotides that form an inve
Publikováno v:
FEBS Letters. 324:59-62
The beta-adrenergic receptor kinase mediates agonist-dependent phosphorylation of beta-adrenergic receptors, which is thought to represent the first step of homologous desensitization. We have expressed bovine and human beta ARK1 in Sf9 cells and pur
Publikováno v:
FEBS Letters. 314:449-454
The wild-type -Phe*Pro- bond located at the N-terminus of the mature aspartic proteinase of HIV-1 was replaced by -Ile-Pro- or -Val-Pro-. By this means, processing at this cleavage junction was prevented and so, extended or precursor forms of HIV-pro
Publikováno v:
FEBS Letters. 283:180-184
Mutations were introduced into the P2 and P1 positions of the junctions, (a) linking reverse transcriptase (RT) and integrase (IN) (-Leu*Phe-) and (b) between the p51 and RNase H domain (-Phe*Tyr-) within p66 of RT in the HIV-1 pol polyprotein. Proce