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Publikováno v:
FEBS Letters. 586:2245-2250
Although SPE-39 is a binding protein to Vps33B that is one of the subunit in the mammalian HOPS complex, the elements of SPE-39 function remain unknown. Here, we show that tyrosine phosphorylation of SPE-39 following EGF stimulation plays a role in t
Publikováno v:
FEBS Letters. 425:209-212
To determine Fas-induced reactive oxygen species (ROS) generation in cells sensitive to Fas-mediated apoptosis, chemiluminescence, a strong indicator of ROS generation, was monitored after stimulation with agonistic anti-Fas. Fas ligation resulted in
Autor:
Ichiro Wakabayashi, Satoshi Matsusaka
Publikováno v:
FEBS letters. 579(30)
The purpose of the present study was to investigate whether 5-hydroxytryptamine (5-HT, serotonin) affects migration of vascular endothelial cells. 5-HT significantly enhanced migration of human aortic endothelial cells (HAECs), and this enhancement w
Publikováno v:
FEBS letters. 505(2)
Treatment of HepG2 cells with forskolin led to 60–100% stimulation of system A activity, measured as the Na+-dependent uptake of α-(methylamino)isobutyric acid. The stimulation was reproducible with cholera toxin and dibutyryl cAMP, and inhibitabl
Autor:
A.R.L Gear, S Suttitanamongkol
Publikováno v:
FEBS letters. 490(1-2)
The ability of the chemokines SDF-1, MDC and TARC to induce platelet aggregation depends strongly on low levels of ADP. The ADP receptors involved have now been characterized using the P2Y1 and P2TAC receptor antagonists, A2P5P and AR-C69931MX. Stimu
Publikováno v:
FEBS letters. 436(2)
The cAMP signaling cascade leading to changes in [Ca2+]i in Dictyostelium discoideum was analyzed using cell lines overexpressing single cAMP receptor subtypes (cAR1-cAR3) or lacking the G(alpha2) or G(beta) subunit of the G protein. Imaging of fura2
Publikováno v:
FEBS letters. 393(2-3)
The amount of thrombospondin (TSP) mRNA in confluent clonal rat dental pulp cells was increased by transforming growth factor-β (TGF-β), 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), and phorbol 12,13-didecanoate (PDD), with maximal levels 6, 36 and 2
Publikováno v:
FEBS letters. 393(1)
We have previously shown that insulin alters the renal metabolism of 25-hydroxyvitamin D. To examine the effect of insulin on vitamin D metabolism in bone, we have used UMR-106 osteoblast-like cells to study the regulation of 25(OH)D3-24-hydroxylase
Publikováno v:
FEBS letters. 391(3)
Hypoosmotic exposure (205 mosmol/l) of rat liver macrophages together with lipopolysaccharide (LPS) inhibited the LPS-induced tumor necrosis factor-alpha (TNF-alpha) release by about 60% and markedly diminished the LPS-induced increase of TNF-alpha m
Publikováno v:
FEBS letters. 301(1)
Skeletal muscle stretch increases resting metabolism and causes hypertrophy. We have examined the effect of mechanical stretch in vitro on glucose transport activity and transporter contents in L6 muscle cells. Long-term (24–48 h) stretch—relaxat