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Publikováno v:
FEBS Letters. 595:2616-2627
Tartrate-resistant acid phosphatase (TRAP, encoded by ACP5)-overexpressing mice exhibit hyperplastic obesity. As the molecular mechanism remains elusive, the aims were to characterize the effect of TRAP on preadipocyte proliferation. We investigated
Autor:
Alejandra Guberman, Camila Vazquez Echegaray, María Soledad Cosentino, Ayelén Toro, Marcos Francia, Elba Vazquez, Claudia Solari, María Victoria Petrone
Publikováno v:
FEBS Letters. 595:1949-1961
In embryonic stem (ES) cells, oxidative stress control is crucial for genomic stability, self-renewal and cell differentiation. Heme oxygenase-1 (HO-1) is a key player of the anti-oxidant system, and is also involved in stem cell differentiation and
Publikováno v:
FEBS Letters. 595:1933-1948
Activated and promoter-bound heat-shock transcription factor 1 (HSF1) induces RNA polymerase II recruitment upon heat shock, and this is facilitated by the core Mediator in Drosophila and yeast. Another Mediator module, CDK8 kinase module (CKM), cons
Publikováno v:
Febs Letters
Neonatal brachial plexus injury (NBPI) causes disabling and incurable muscle contractures that are driven by impaired growth of denervated muscles. A rare form of NBPI, which maintains afferent muscle innervation despite motor denervation, does not c
Autor:
Shouhai Zhu, Shufeng Xie, Han Liu, Dan Li, Zhihong Chen, Ruiheng Wang, Qiongyu Xu, Xiaoyan Cheng, Maolin Ge
Publikováno v:
FEBS Letters. 595:462-475
Transplantation of in vitro-manipulated cells is widely used in hematology. While transplantation is well recognized to impose severe stress on transplanted cells, the nature of transplant-induced stress remains elusive. Here, we propose that the lac
Publikováno v:
FEBS Letters. 594:4370-4380
Insulin stimulates glucose uptake via the translocation of the glucose transporter GLUT4 to the plasma membrane in adipocytes. Several lines of evidence suggest that the small GTPase Rac1 plays an important role in insulin-stimulated glucose uptake i
Autor:
Chongyi Shu, Xiaopan Chen, Linjie Chen, Leixiang Yang, Fei Tao, Kaiqiang Li, Feihang Ge, Jianxin Lyu, Weiling Xiang, Bingyu Chen, Yeting Hong, Ke Hao, Yangyang Zhang, Zhen Wang, Wei Zhang
Publikováno v:
FEBS Letters. 594:2881-2893
Regeneration is a unique defense mechanism of liver tissue in response to functional cell loss induced by toxic chemicals or surgical resection. In this study, we found that Islet-cell autoantigen 69 (Ica69) accelerates liver regeneration in mice. Fo
Publikováno v:
Febs Letters
The primary function of cyclin-dependent kinases (CDKs) in complex with their activating cyclin partners, is to promote mitotic division in somatic cells. This canonical cell cycle-associated activity is also crucial for fertility as it allows the pr
Autor:
Nandini Ghosh-Choudhury, Soumya Maity, Falguni Das, Balakuntalam S. Kasinath, Goutam Ghosh Choudhury
Publikováno v:
FEBS Letters. 593:2261-2272
The mechanism of PTEN repression by high glucose in diabetic nephropathy is not known. Using proximal tubular cells, we show that inhibition of PI3 kinase/Akt and their inactive enzymes prevents high glucose-induced PTEN downregulation. Similarly, ra
Publikováno v:
FEBS Letters. 593:2040-2050
Oncostatin M (OSM) is a member of the interleukin-6 (IL-6) family, which functions in embryo implantation and decidualization. The expression, function and regulation of Osm in mouse uteri during early pregnancy remain unknown. We show that Osm is ma