Zobrazeno 241 - 250
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Autor:
Licio A. Velloso, Juliana C. Moraes, Talita Romanatto, Paty K. Picardi, Silvana Chiavegatto, Marcela Bermúdez-Echeverry, Vivian C. Calegari, Maria Esméria Corezola do Amaral, Mario J.A. Saad
Publikováno v:
FEBS letters. 580(19)
TNF-alpha acts on the hypothalamus modulating food intake and energy expenditure through mechanisms incompletely elucidated. Here, we explore the hypothesis that, to modulate insulin-induced anorexigenic signaling in hypothalamus, TNF-alpha requires
Autor:
Isabelle Moranvillier, Sandrine Arnaud-Dabernat, Nadine Dragin, Clément Dubost, Pierre Costet, Evelyne Peuchant, Moneïm Smani, Jean-Yves Daniel
Publikováno v:
FEBS letters. 580(16)
Oxidative stress is known to produce tissue injury and to activate various signaling pathways. To investigate the molecular events linked to acute oxidative stress in mouse liver, we injected a toxic dose of paraquat. Liver necrosis was first observe
Publikováno v:
FEBS letters. 580(19)
Tumor necrosis factor-alpha (TNF-alpha) induces the transcriptional activation of numerous genes involved in the inflammatory response. The recently identified protein TRUSS was investigated for its role in TNF-alpha-induced activation of c-Jun-NH(2)
Publikováno v:
FEBS letters. 580(17)
Non-receptor tyrosine kinase Abl is a well known regulator of the actin-cytoskeleton, including the formation of stress fibers and membrane ruffles. Vinexin is an adapter protein consisting of three SH3 domains, and involved in signal transduction an
Publikováno v:
FEBS letters. 580(9)
The mitochondria-associated adapter protein MAVS (also called IPS-1, VISA or CARDIF, designated MAVS for reasons of simplicity in our manuscript) relays signals from cytoplasmic sensors of viral RNA to the IRF3 kinase complex and the interferon-beta
Autor:
Delphine Lavens, Julie Piessevaux, Joris Wauman, Tony Montoye, Joël Vandekerckhove, Dominiek Catteeuw, Jan Tavernier, Irma Lemmens
Publikováno v:
FEBS letters. 580(13)
The adipocyte-secreted hormone leptin participates in the regulation of hematopoiesis and enhances proliferation of hematopoietic cells. We used an adaptation of the MAPPIT mammalian two-hybrid method to study leptin signalling in a hematopoietic set
Publikováno v:
FEBS letters. 580(6)
We tested whether any intracellular signals are transmitted through 4-1BB/CD137 ligand (4-1BBL), using a 4-1BB-Fc fusion protein and 4-1BB-deficient mice. Immobilized 4-1BB-Fc fusion protein strongly inhibited osteoclastogenesis induced by macrophage
Autor:
Takayuki Ikeda, Shin Takasawa, Hiroshi Okamoto, Akiyo Yamauchi, Takako Akiyama, Kei Nakagawa, Naoya Noguchi, Tomoko Tomioka-Kumagai, Koji Nata, Shoko Murakami-Kawaguchi, Nausheen J. Shervani, Iwao Takahashi
Publikováno v:
FEBS letters. 580(2)
Regenerating gene product (Reg) is induced in pancreatic beta-cells and acts as an autocrine/paracrine growth factor for regeneration via a cell surface Reg receptor. However, the manner by which Reg induces beta-cell regeneration was unknown. In the
Autor:
Andrew C Robinson, Cathy Tournier, Midori Kayahara, Katherine G. Finegan, Xin Wang, Emmanouil S. Papadakis, Chun Guo
Publikováno v:
FEBS letters. 580(5)
The signaling mechanism by which JNK affects mitochondria is critical to initiate apoptosis. Here we show that the absence of JNK provides a partial resistance to the toxic effect of the heavy metal cadmium. Both wild type and jnk−/− fibroblasts
Publikováno v:
FEBS letters. 580(1)
Osteoblastic differentiation is an essential part of bone formation. Dimethyl sulfoxide (DMSO) is a water miscible solvent that is used extensively for receptor ligands in osteoblast studies. However, little is known about its effects on osteoblastog