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Autor:
Guoliang Cui, Tilo Schlimbach, Sicong Ma, Jingxia Wu, Michael Schmitt, Agnes Hotz-Wagenblatt, Peter Angel, Kerstin Mohr
Publikováno v:
FEBS letters. 593(10)
To maintain immune tolerance, effector T-cell (Teff) responses must be checked by the regulatory T cells (Tregs) in time. It remains incompletely understood how Tregs sense real-time Teff activation. Here, we report that the AP-1 transcription factor
Publikováno v:
FEBS Letters. 587:3027-3031
Osteogenesis depends on a coordinated network of transcription factors including Sp7. Emerging evidence indicates that microRNAs (miRNAs) act as pivotal regulators in various biological processes including osteoblast proliferation and differentiation
Publikováno v:
FEBS Letters. 587:826-832
The transcription factor Gli1 acts in the last known step of the Hedgehog signaling, and deregulation of Gli1 is implicated in human cancers. VHL protein is widely expressed in both fetal and adult tissues and acts as a tumor suppressor. Here, we dem
Autor:
Joan Massagué, Qiaoran Xi
Publikováno v:
FEBS Letters. 586:1953-1958
The canonical TGF-β/Smad signaling pathway was delineated in the mid 90s and enriched over the past decade with many findings about its specificity, regulation, networking, and malfunctions in disease. However, a growing understanding of the chromat
Publikováno v:
FEBS letters. 590(3)
miRNAs play a number of roles in bone, including mediating the pathological effects of inflammation. Here, we found that miR-33a-5p expression was significantly increased after TNF-α treatment during BMP-2-induced osteogenic differentiation of hBMSC
Publikováno v:
FEBS Letters. 581:5247-5254
ES cells can self-renew while preserving pluripotency and are able to differentiate into many cell types. In both processes, different signal transduction pathways are implicated, including the Wnt/beta-catenin pathway, which we here further analyzed
Publikováno v:
FEBS Letters. 579:1047-1054
Jab1 interacts with a variety of cell cycle and signal transduction regulators to control cell proliferation, differentiation, and tumorigenesis. In this study, we employed a non-denaturing gel electrophoresis method to separate different Jab1-contai
Publikováno v:
FEBS Letters. 542:109-114
While peripheral oscillators can be reset by humoral factors such as glucocorticoid hormones, indirect neural communications involving sympathetic and parasympathetic neurons from the suprachiasmatic nucleus to various peripheral tissues suggest that
Autor:
Rakesh Kumar, Abhijit Mazumdar
Publikováno v:
FEBS Letters. 535:6-10
Stimulation of p21-activated kinase-1 (Pak1) and estradiol-estrogen receptor-α in mammary cancer cells promotes cell survival. We sought to determine whether estrogen stimulates the Pak1 pathway. We found that estrogen rapidly activated Pak1 kinase
Publikováno v:
FEBS Letters. 526:142-146
PIAS3, a member of the protein inhibitor of activated STAT family, was found to interact in vivo and in vitro with TIF2, a previously described coactivator for nuclear receptors. The interaction is mediated by two distinct non-contiguous regions of T