Zobrazeno 1 - 10
of 40
pro vyhledávání: ''
Publikováno v:
FEBS Letters. 595:2616-2627
Tartrate-resistant acid phosphatase (TRAP, encoded by ACP5)-overexpressing mice exhibit hyperplastic obesity. As the molecular mechanism remains elusive, the aims were to characterize the effect of TRAP on preadipocyte proliferation. We investigated
Publikováno v:
FEBS Letters. 594:4370-4380
Insulin stimulates glucose uptake via the translocation of the glucose transporter GLUT4 to the plasma membrane in adipocytes. Several lines of evidence suggest that the small GTPase Rac1 plays an important role in insulin-stimulated glucose uptake i
Autor:
Chongyi Shu, Xiaopan Chen, Linjie Chen, Leixiang Yang, Fei Tao, Kaiqiang Li, Feihang Ge, Jianxin Lyu, Weiling Xiang, Bingyu Chen, Yeting Hong, Ke Hao, Yangyang Zhang, Zhen Wang, Wei Zhang
Publikováno v:
FEBS Letters. 594:2881-2893
Regeneration is a unique defense mechanism of liver tissue in response to functional cell loss induced by toxic chemicals or surgical resection. In this study, we found that Islet-cell autoantigen 69 (Ica69) accelerates liver regeneration in mice. Fo
Autor:
Guoliang Cui, Tilo Schlimbach, Sicong Ma, Jingxia Wu, Michael Schmitt, Agnes Hotz-Wagenblatt, Peter Angel, Kerstin Mohr
Publikováno v:
FEBS letters. 593(10)
To maintain immune tolerance, effector T-cell (Teff) responses must be checked by the regulatory T cells (Tregs) in time. It remains incompletely understood how Tregs sense real-time Teff activation. Here, we report that the AP-1 transcription factor
Autor:
Linqiang Li, Jiancheng Yang, Leigh Darryl Quarles, Gwendalyn D. King, Xiaobin Han, Zhousheng Xiao
Publikováno v:
FEBS Letters. 590:53-67
Mechanisms underlying the association between fibroblastic growth factor 23 (FGF-23) and inflammation are uncertain. We found that FGF-23 was markedly up-regulated in LPS/INF-γ-induced proinflammatory M1 macrophages and Hyp mouse-derived peritoneal
Publikováno v:
FEBS Letters. 588:1692-1698
Endotoxin-induced uveitis (EIU) is an animal model of acute ocular inflammation for the study of human endogenous anterior uveitis. The mechanisms accounting for the development of ocular inflammation remain hazy. MicroRNAs (mi-RNAs) have been propos
Autor:
Zhiyong Gao, Jichun Yang, Jing Li, Claudia E. Robert-Cooperman, Chunjiong Wang, Brant R. Burkhardt, Camella G. Wilson, Bryan A. Wolf
Publikováno v:
FEBS Letters. 583:3009-3015
PANDER is a cytokine co-secreted with insulin from islet β-cells. To date, the physiological function of PANDER remains largely unknown. Here we show that PANDER binds to the liver membrane by 125I-PANDER saturation and competitive binding assays. I
Autor:
Maki Kagishita, Yoshihisa Yamashita, Yoshikazu Masuhiro, Noboru Yamaguchi, Toshiyuki Saito, Shigemasa Hanazawa, Kazuaki Nonaka, Jose Guillermo Martinez Argueta
Publikováno v:
FEBS Letters. 579:6821-6826
Recent studies have shown that adiponectin, an adipocyte-derived cytokine, acts as a potent inhibitor of inflammatory responses. It has been also demonstrated that bacterial and viral signalings in host cells are triggered via Toll-like receptor (TLR
Autor:
Lawrence M. Schwartz, Zhengliang Gao
Publikováno v:
FEBS Letters. 579:5651-5657
Hic-5/ARA55 is a LIM-only member of the paxillin superfamily. Conflicting reports have suggested that Hic-5/ARA55 can both repress and enhance a number of biological processes, including myogenesis and tumorigenesis. With two Hic-5 isoforms documente
Publikováno v:
FEBS Letters. 565:70-74
SH2 domain containing inositol polyphosphate 5-phosphatase (SHIP2) dephosphorylates phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) into phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). SHIP2 knock-out mice demonstrated that SHIP2 ac